Data/hora: 23/09/2024 12:19:09

Biblioteca(s): 	Embrapa Rondônia.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	Internacional - A	
Data corrente: 	06/01/2009	
Data da última atualização: 	07/08/2024	
Autoria: 	ALMEIDA, M. R.; LIMA, E. de O.; SILVA, V. J. D. da; CAMPOS, M. G.; ANTUNES, L. M. G.; SALMAN, A. K. D.; DIAS, F. L.	
Afiliação: 	MARA RIBEIRO ALMEIDA, UNIVERSIDADE FEDERAL DO TRIÂNGULO MINEIRO; ESTELA DE OLIVEIRA LIMA, UNIVERSIDADE DE SÃO PAULO; VALDO JOSÉ DIAS DA SILVA, UNIVERSIDADE FEDERAL DO TRIÂNGULO MINEIRO; MATEUS GANDRA CAMPOS, UNIVERSIDADE FEDERAL DO TRIÂNGULO MINEIRO; LUSÂNIA M. G. ANTUNES, UNIVERSIDADE DE SÃO PAULO; ANA KARINA DIAS SALMAN, CPAF-RO; FRANCISCA L. DIAS, FACULDADES INTEGRADAS APARÍCIO CARVALHO.	
Título: 	Genotoxic studies in hypertensive and normotensive rats treated with amiodarone.	
Ano de publicação: 	2008	
Fonte/Imprenta: 	Mutation Research. Genetic Toxicology and Environmental Mutagenesis, v. 657, n. 2, p. 155-159, 2008.	
DOI: 	https://doi.org/10.1016/j.mrgentox.2008.09.005	
Idioma: 	Inglês	
Conteúdo: 	Amiodarone, a benzofuran derivative, is a very effective antiarrhythmic medication, but has potential to cause side effects. Although its cytotoxicity potential is very well-known, there are few reports about its genotoxicity effects. Since amiodarone has not been investigated in genotoxicity studies, and the spontaneously hypertensive rat (SHR) is a well-characterized model for hypertension, the aim of the present study was to perform cytogenetic analysis on chromosome aberrations in bone marrow cells of SHRs and normotensive Wistar-Kyoto rats (WKYs) that received oral amiodarone treatment for 4 weeks. Amiodarone activity was also monitored using electrocardiograms. The presence of bradycardia in amiodarone-treated rats confirmed that this drug was really active. Metaphase analysis on bone marrow cells showed that there were significant differences in total chromosomal damage and percentage abnormal metaphase between WKY and SHR negative controls. In the SHR negative control, the frequencies of basal chromosomal aberrations and abnormal metaphases were significantly higher (p < 0.05). There were high numbers of chromosomal aberrations in all amiodarone-treated groups, compared with negative controls. In amiodarone-treated groups, the most frequent chromosomal aberration was chromatid breaks. More chromosomal aberrations were found in WKYs that received amiodarone, with a statistically significant difference in comparison with negative controls (p < 0.05). However, in SHR rats there was no significant difference between the amiodarone and negative groups regarding chromosomal damage induction. These results showed that treatment with amiodarone was genotoxic in WKYs, but not in SHRs. Further studies are needed to confirm whether amiodarone is genotoxic or efficient and harmless, among humans undergoing therapy.	
Palavras-Chave: 	Amiodarone.	
Thesaurus Nal: 	Rats.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/709150/1/Genotoxic-studies.pdf	
Registro original: 	Embrapa Rondônia (CPAF-RO)	
Exemplares: 	CPAF-RO - (12930-1) - UPC - AP - DD -  -  -  - DIS