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| Registros recuperados : 70 | |
| 61. |  | AFONSO, J.; SHIM, W. J.; BODEN, M.; FORTES, M. R. S.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; CARDOSO, T. F.; BRUSCADIN, J. J.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; REGITANO, L. C. de A. Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. Biochemistry and Biophysics Reports, v. 33, 101420, Mar. 2023.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 62. | | LIMA, A. O. D.; OLIVEIRA, P. S. N.; TIZIOTO, P. C.; SOMAVILLA, A. L.; DINIZ, W. J. S.; SILVA, J. V. D.; ANDRADE, S. C. S.; BOSCHIERO, C.; CESAR, A. S. M.; SOUZA, M. M.; ROCHA, M. I. P.; AFONSO, J.; BUSS, C. E.; MUDADU, M. de A.; MOURAO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. PRUNE2 gene has a potential effect on residual feed intake in Nellore cattle. Journal of Animal Science, v. 94, p. 152-153, 2016. Supplement 5.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 63. | | LIMA, A. O. D.; OLIVEIRA, P. S. N.; TIZIOTO, P. C.; SOMAVILLA, A. L.; DINIZ, W. J. S.; SILVA, J. V. D.; ANDRADE, S. C. S.; BOSCHIERO, C.; CESAR, A. S. M.; SOUZA, M. M.; ROCHA, M. I. P.; AFONSO, J.; BUSS, C. E.; MUDADU, M. de A.; MOURAO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. PRUNE2 gene has a potential effect on residual feed intake in Nellore cattle. Journal of Animal Science, v. 94, p. 152-153, 2016. p. 148-149. Supplement 5.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 64. | | LIMA, A. O.; MALHEIROS, J. M.; AFONSO, J.; PETRINI, J.; COUTINHO, L. L.; DINIZ, W. J. da S.; DONATONI, F. A. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; RIBEIRO, J. A. S.; OLIVEIRA, K. S. de; ROCHA, M. I. P.; ANDRADE, B. G. N.; FUKUMASU, H.; BEIKI, H.; REECY, J. M.; ZERLOTINI NETO, A.; MOURAO, G. B.; REGITANO, L. C. de A. Prune homolog 2 with BCH domain (PRUNE2) gene expression is associated with feed efficiency related traits in Nelore steers. Mammalian Genome, 2022.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 65. | | AFONSO, J.; LINS, L. A.; CASSARO, E. G.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de O.; DINIZ, W. J. da S.; LIMA, A. O. de; SOUZA, M. M. de; ROCHA, M. I. P.; SILVA, J. V. da; BUSS, C. E.; GROMBONI, C. F.; MOURAO, G. B.; NOGUEIRA, A. R. de A.; COUTINHO, L. L.; REGITANO, L. C. de A. Putative genes involved in muscle functioning are differentially expressed in Nelore steers divergent for sodium and potassium concentration. In: WORKSHOP ON OMICS STRATEGIES APPLIED TO LIVESTOCK SCIENCE, 1., 2017, Piracicaba, SP. Proceedings... São Carlos, SP: Embrapa Pecuária Sudeste, 2017. p. 18. (Embrapa Pecuária Sudeste. Documentos, 125) Editores: Luiz Lehmann Coutinho, ESALQ/USP; Luciana Correia de Almeida Regitano, Embrapa Pecuária Sudeste; Gerson Barreto Mourão, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; Bárbara Silva Vignato, FZEA/USP; Mirele Daiana Poleti,...| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 66. | | AFONSO, J.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; DINIZ, W. J. da S.; LIMA, A. O.; SOUZA, M. M. de; ROCHA, M. I. P.; SILVA, J. V. da; BUSS, C. E.; GROMBONI, C. F.; MOURÃO, G. B.; NOGUEIRA, A. R. de A.; COUTINHO, L. L.; REGITANO, L. C. de A. Differentially expressed genes in genetically divergent Nellore steers for calcium content in the Longissimus dorsi muscle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 427, jul. 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 67. | | SILVA, J. V. da; TIZIOTO, P. C.; NEUBERN, P. S. N. de; AFONSO, J.; DINIZ, W. J. da S.; LIMA, A. O. de; SOUZA, M. M. de; ROCHA, M. I. P.; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Differentially expressed genes in Longissimus dorsi muscle of Nelore steers divergent for average daily gain. In: INTERNATIONAL MEETING OF ADVANCES IN ANIMAL SCIENCE (IMAS), 2016, Jaboticabal. [Proceedings...]. Jaboticabal: Galoá, 2016. 1| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 68. | | DINIZ, W. J. da S.; TIZIOTO, P. C.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; ROSA, K. de O. da; CESAR, A. S. M.; OLIVEIRA, P. S. N. de; SOUZA, M. de; LIMA, A. O. de; COUTINHO, L. L.; REGITANO, L. C. de A. Perfil transcriptômico do músculo Longissimus dorsi de bovinos Nelore extremos para conteúdo de ferro. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA PARA O PROGRESSO DA CIÊNCIA, 67., 2015, São Carlos, SP. Resumos....São Paulo: SBPC, 2015 C. 3-2| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 69. | | AFONSO, J.; COUTINHO, L. L.; TIZIOTO, P. C.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; BUSS, C, E.; ANDRADE, B. G. N. A.; PIAYA. O.; SILVA, J. V.; LINS, L. A.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; FORTES, M. R. S.; MOURÃO, G. B.; REGITANO, L. C. de A. Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indicus. Scientific Reports, v. 9, n. 12715, 2019.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 70. | | MOKRY, F. B.; BUZANSKAS, M. E.; MUDADU, M. de A.; GROSSI, D. do A.; HIGA, R. H.; VENTURA, R. V.; LIMA, A. O. de; SARGOLZAEI, M.; MEIRELLES, S. L. C.; SCHENKEL, F. S.; SILVA, M. V. G. B.; NICIURA, S. C. M.; ALENCAR, M. M. de; MINARI, D. P.; REGITANO, L. C. de A. Linkage disequilibrium and haplotype block structure in a composite beef cattle breed. BMC Genomics, London v. 15, S6, p. 1-9, 2014. Suppl 7.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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| Registros recuperados : 70 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
09/02/2023 |
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Data da última atualização: |
10/02/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
AFONSO, J.; SHIM, W. J.; BODEN, M.; FORTES, M. R. S.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; CARDOSO, T. F.; BRUSCADIN, J. J.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
JULIANA AFONSO; WOO JUN SHIM, THE UNIVERSITY OF QUEENSLAND; MIKAEL BODEN, THE UNIVERSITY OF QUEENSLAND; MARINA RUFINO SALINAS FORTES, THE UNIVERSITY OF QUEENSLAND; WELLISON JARLES DA SILVA DINIZ, AUBURN UNIVERSITY; ANDRESSA OLIVEIRA DE LIMA, UNIVERSITY OF WASHINGTON; MARINA IBELLI PEREIRA ROCHA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; TAINÃ FIGUEIREDO CARDOSO; JENNIFER JESSICA BRUSCADIN, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAIO FERNANDO GROMBONI, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DA BAHIA; ANA RITA ARAUJO NOGUEIRA; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Biochemistry and Biophysics Reports, v. 33, 101420, Mar. 2023. |
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DOI: |
https://doi.org/10.1016/j.bbrep.2023.101420 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified. MenosAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expressio... Mostrar Tudo |
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Palavras-Chave: |
Epigenetic regulation; Expressão gênica; Gene repression; H3K27me3. |
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Thesagro: |
Bos Indicus; Gado de Corte; Gado Nelore; Mineral. |
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Thesaurus NAL: |
Epigenetics; Gene expression; Minerals. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1151623/1/AP-Repressive-epigenetic-2023.pdf
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Marc: |
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024 7 $ahttps://doi.org/10.1016/j.bbrep.2023.101420$2DOI
100 1 $aAFONSO, J.
245 $aRepressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle.$h[electronic resource]
260 $c2023
520 $aAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified.
650 $aEpigenetics
650 $aGene expression
650 $aMinerals
650 $aBos Indicus
650 $aGado de Corte
650 $aGado Nelore
650 $aMineral
653 $aEpigenetic regulation
653 $aExpressão gênica
653 $aGene repression
653 $aH3K27me3
700 1 $aSHIM, W. J.
700 1 $aBODEN, M.
700 1 $aFORTES, M. R. S.
700 1 $aDINIZ, W. J. da S.
700 1 $aLIMA, A. O. de
700 1 $aROCHA, M. I. P.
700 1 $aCARDOSO, T. F.
700 1 $aBRUSCADIN, J. J.
700 1 $aGROMBONI, C. F.
700 1 $aNOGUEIRA, A. R. A.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tBiochemistry and Biophysics Reports$gv. 33, 101420, Mar. 2023.
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