Data/hora: 25/06/2024 11:51:13

Biblioteca(s): | Embrapa Gado de Leite.
Tipo da produção científica: | Artigo em Periódico Indexado
Circulação/Nível: | A - 1
Data corrente: | 26/11/2013
Data da última atualização: | 05/02/2024
Autoria: | PENEDO, L. A.; NUNES, J. C.; GAMA, M. A. S. da; LEITE, P. E. C.; QUIRICO-SANTOS, T. F.; TORRES, A. G.
Afiliação: | LETÍCIA A. PENEDO, UFRJ, UFF; JULIANA C. NUNES, UFRJ; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; PAULO EMILIO C. LEITE, UFF; THEREZA F. QUIRICO-SANTOS, UFF; ALEXANDRE G. TORRES, UFRJ.
Título: | Intake of butter naturally enriched with cis9, trans11 conjugated linoleic acid reduces systemic inflammatory mediators in healthy young adults.
Ano de publicação: | 2013
Fonte/Imprenta: | Journal of Nutritional Biochemistry, v. 24, p. 2144-2151, 2013.
DOI: | https://doi.org/10.1016/j.jnutbio.2013.08.006
Idioma: | Inglês
Conteúdo: | A conjugated linoleic acid (CLA) depletion-repletion study was carried out to investigate the effects of dietary c9,t11 CLA on C-reactive protein, transcription factor NFκB, metalloproteinases 2 and 9, inflammatory mediators (adiponectin, TNFα, IL-2, IL-4, IL-8, IL-10), body composition, and erythrocyte membrane composition in healthy normal-weight human adults. CLA depletion was achieved through an 8-week period of restricted dairy fat intake (depletion phase; CLA intake was 5.2±5.8 mg/day), followed by an 8-week period in which individuals consumed 20 g/day of butter naturally enriched with c9,t11 CLA (repletion phase; CLA intake of 1020±167 mg/day). The participants were 29 healthy adult volunteers (19 women and 10 men, aged 22 to 36 years), with body mass index between 18.0 and 29.9 kg m(-2). Blood samples were collected at baseline and at the end of both depletion and repletion phases. The content of CLA in erythrocytes decreased during CLA-depletion and increased during CLA-repletion. Intake of CLA-enriched butter increased the serum levels of anti-inflammatory IL-10 but reduced transcription factor NFκB in blood and serum levels of TNFα, IL-2, IL-8 and inactive metalloproteinase-9. Moreover, reduced activity of metalloproteinases 2 and 9 in serum was observed during the CLA-repletion period. In contrast, intake of CLA-enriched butter had no effects on body composition (DXA analysis) as well as on serum levels of adiponectin, C-reactive protein, and IL-4. Taken together, our results indicate that the intake of a c9,t11 CLA-enriched butter by normal-weight subjects induces beneficial changes in immune modulators associated with sub-clinical inflammation in overweight individuals.
Palavras-Chave: | Bioactive lipid; Depletion-repletion; Rumenic acid.
Thesaurus Nal: | cytokines; inflammation.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
Registro original: | Embrapa Gado de Leite (CNPGL)
Exemplares: | CNPGL - (20764-1) - UPC - AP - DD -  -  -  - DIS