Data/hora: 23/09/2024 12:49:18

Biblioteca(s): 	Embrapa Agroindústria de Alimentos.	
Data corrente: 	05/04/2021	
Data da última atualização: 	15/06/2021	
Autoria: 	GONÇALVES, G. M.; MARTINS, V. de C.; COSTA, A. R. H. da; FERNANDES, T. F. da C.; PACHECO, S.; GAMA, P. E.; SOUZA, M. da C.; GODOY, R. L. de O.; LAUREANO-MELO, R.; CÔRTES, W. da S.; CARVALHO, M. G. de; MARINHO, B. G.	
Afiliação: 	GABRIELA MASTRANGELO GONÇALVES, UFRRJ; VÍCTOR DE CARVALHO MARTINS, UFRRJ; ANDRÉ ROMERO HENRIQUE DA COSTA, UFRRJ; THAYANE FERREIRA DA COSTA FERNANDES, Universidade Federal Fluminense, Rio das Ostras; SIDNEY PACHECO, CTAA; PAOLA ERVATTI GAMA, CTAA; MARCELO DA COSTA SOUZA, Herbário RBR, Instituto de Ciências Biológicas e da Saúde, UFRRJ; RONOEL LUIZ DE OLIVEIRA GODOY, CTAA; ROBERTO LAUREANO-MELO, Centro Universitário de Barra Mansa; WELLINGTON DA SILVA CÔRTES, UFRRJ; MARIO GERALDO DE CARVALHO, UFRRJ; BRUNO GUIMARÃES MARINHO, UFRRJ.	
Título: 	Essential oil of Myrciaria tenella (DC.) O. Berg:effects of distillation time on its chemicalcomposition and evaluation of its anti-inflammatory and antinociceptive effects.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	The Journal Of Essential Oil Reseach, 2021. p. 1-17.	
DOI: 	https://doi.org/10.1080/10412905.2021.1899993	
Idioma: 	Inglês	
Conteúdo: 	The objective of the present study was to characterize the essential oil of Myrciaria tenella (MTEO) leaves, to determine the effects of distillation time (1 to 5 h), and to evaluate its action on acute pain and inflammation both in vivo and in vitro. MTEO was obtained by hydrodistillation for 4 h and 36 compounds were detected, mainly consisting of hydrocarbon terpenes such as &#946;-pinene (21.46%), &#945;-pinene (19.43%), E-caryophyllene (10.89%) and aromadendrene (9.17%). A high yield of &#945;-pinene/&#946;-pinene-rich MTEO was obtained after only 2 h of extraction. For in vivo biological assays, MTEO was administered to male Swiss mice, showing an action against hypernociception (acetic acid-induced abdominal writhing, formalin and Von Frey models) and inhibiting carrageenan-induced paw edema. Production of IL-6, TNF-&#945;, IL-1&#946;, PGE2 was reduced and production of IL-10 was increased, with no change in motor performance. MTEO also reduced cell production of NO and cytokines, in addition to inhibiting COX activity.	
Palavras-Chave: 	Citocinas; Hipernocicepção inflamatória; Inflammatory hypernociception; Myrciaria tenella; Ratos; Terpenes.	
Thesagro: 	Óleo Essencial; Produto de Origem Vegetal.	
Thesaurus Nal: 	Cytokinesis; Essential oils; Mice; Myrciaria; Vegetable products.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
Registro original: 	Embrapa Agroindústria de Alimentos (CTAA)	
Exemplares: 	CTAA - (15152-1) - UPC - AP - DD -  -  -  - DIS