Data/hora: 17/06/2024 03:34:29

Biblioteca(s): 	Embrapa Suínos e Aves.	
Data corrente: 	11/09/2023	
Data da última atualização: 	11/09/2023	
Autoria: 	JUNQUEIRA, D. M.; TOCHETTO, C.; ANDERSON, T. K.; GAVA, D.; HAACH, V.; CANTAO, M. E.; BAKER, A. L. V.; SCHAEFER, R.	
Afiliação: 	DENNIS MALETICH JUNQUEIRA, Universidade Federal de Santa Maria; CAROLINE TOCHETTO; TAVIS K. ANDERSON, Virus and Prion Research Unit/USDA; DANIELLE GAVA, CNPSA; VANESSA HAACH, Universidade Federal do Rio Grande do Sul; MAURICIO EGIDIO CANTAO, CNPSA; AMY L. VINCENT BAKER, Virus and Prion Research Unit/USDA; REJANE SCHAEFER, CNPSA.	
Título: 	Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil.	
Ano de publicação: 	2023	
Fonte/Imprenta: 	Frontiers in Microbiology, v. 14, article 1243567, 2023.	
DOI: 	https://doi.org/10.3389/fmicb.2023.1243567	
Idioma: 	Inglês	
Conteúdo: 	Abstract: Introduction: Once established in the human population, the 2009 H1N1 pandemic virus (H1N1pdm09) was repeatedly introduced into swine populations globally with subsequent onward transmission among pigs. Methods: To identify and characterize human-to-swine H1N1pdm09 introductions in Brazil, we conducted a large-scale phylogenetic analysis of 4,141 H1pdm09 hemagglutinin (HA) and 3,227 N1pdm09 neuraminidase (NA) gene sequences isolated globally from humans and swine between 2009 and 2022. Results: Phylodynamic analysis revealed that during the period between 2009 and 2011, there was a rapid transmission of the H1N1pdm09 virus from humans to swine in Brazil. Multiple introductions of the virus were observed, but most of them resulted in self-limited infections in swine, with limited onward transmission. Only a few sustained transmission clusters were identified during this period. After 2012, there was a reduction in the number of human-to-swine H1N1pdm09 transmissions in Brazil. Discussion: The virus underwent continuous antigenic drift, and a balance was established between swine-to-swine transmission and extinction, with minimal sustained onward transmission from humans to swine. These results emphasize the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.	
Palavras-Chave: 	H1N1; Spillover.	
Thesagro: 	Contaminação; Suíno.	
Thesaurus Nal: 	Brazil; Influenza A virus; Spreaders; Swine.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Suínos e Aves (CNPSA)	
Exemplares: 	CNPSA - (22591-1) - UPC - AP - DD -  -  -  - DIS