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| 2. |  | MARES-GUIA, T. R.; MAIGRET, B.; MARTINS, N. F.; MAIA, A. L. T.; VILELA, L.; RAMOS, C. H. I.; JULIANO NETO, L.; JULIANO, M. A.; MARES-GUIA, M. L. dos; SANTORO, M. M. Molecular dynamics and circular dichroism studies of human and rat C-peptides. Journal of Molecular Graphics and Modelling, v. 25, n. 4, p. 532-542, Dec. 2006.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 3. | | DIAS, A. T.; CASTRO, S. B. R. de; ALVES, C. C. de S.; EVANGELISTA, M. G.; SILVA, L. C. da; REIS, D. R. de L.; MACHADO, M. A.; JULIANO, M. A.; FERREIRA, A. P. Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis. Inflammation Research, v. 67, n. 7, p. 597-608, 2018.| Biblioteca(s): Embrapa Gado de Leite. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
19/12/2018 |
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Data da última atualização: |
02/07/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
DIAS, A. T.; CASTRO, S. B. R. de; ALVES, C. C. de S.; EVANGELISTA, M. G.; SILVA, L. C. da; REIS, D. R. de L.; MACHADO, M. A.; JULIANO, M. A.; FERREIRA, A. P. |
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Afiliação: |
ALYRIA TEIXEIRA DIAS, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; SANDRA BERTELLI RIBEIRO DE CASTRO, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; CAIO CÉSAR DE SOUZA ALVES, UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI; MARCILENE GOMES EVANGELISTA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; LUAN CRISTIAN DA SILVA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; DANIELE RIBEIRO DE LIMA REIS FAZA, CNPGL; MARCO ANTONIO MACHADO, CNPGL; MARIA APARECIDA JULIANO, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANA PAULA FERREIRA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA. |
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Título: |
Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Inflammation Research, v. 67, n. 7, p. 597-608, 2018. |
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DOI: |
10.1007/s00011-018-1146-7 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day 6 postimmunization. METHODS: Animals were monitored daily for clinical signs of EAE up to day 21. Inflammatory infiltration, demyelination, Toll-like receptor (TLR) expression, cytokines and transcription factors were analyzed in spinal cords. RESULTS: The present study demonstrates, for the first time, the genistein ability to modulate the factors involved in the innate immune response in the early stages of EAE. The genistein therapy delayed the onset of the disease, with reduced inflammatory infiltration and demyelination. In addition, the expression of TLR3, TLR9 and IFN-β were increased in genistein group, with reduction in the factors of TH1 and Th17 cells. CONCLUSION: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention. |
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Palavras-Chave: |
Experimental autoimmune encephalomyelitis; IFN-beta; Multiple sclerosis; Toll-like. |
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Thesaurus NAL: |
Immune response. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02278naa a2200289 a 4500
001 2102082
005 2024-07-02
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1007/s00011-018-1146-7$2DOI
100 1 $aDIAS, A. T.
245 $aGenistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis.$h[electronic resource]
260 $c2018
520 $aAbstract OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day 6 postimmunization. METHODS: Animals were monitored daily for clinical signs of EAE up to day 21. Inflammatory infiltration, demyelination, Toll-like receptor (TLR) expression, cytokines and transcription factors were analyzed in spinal cords. RESULTS: The present study demonstrates, for the first time, the genistein ability to modulate the factors involved in the innate immune response in the early stages of EAE. The genistein therapy delayed the onset of the disease, with reduced inflammatory infiltration and demyelination. In addition, the expression of TLR3, TLR9 and IFN-β were increased in genistein group, with reduction in the factors of TH1 and Th17 cells. CONCLUSION: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention.
650 $aImmune response
653 $aExperimental autoimmune encephalomyelitis
653 $aIFN-beta
653 $aMultiple sclerosis
653 $aToll-like
700 1 $aCASTRO, S. B. R. de
700 1 $aALVES, C. C. de S.
700 1 $aEVANGELISTA, M. G.
700 1 $aSILVA, L. C. da
700 1 $aREIS, D. R. de L.
700 1 $aMACHADO, M. A.
700 1 $aJULIANO, M. A.
700 1 $aFERREIRA, A. P.
773 $tInflammation Research$gv. 67, n. 7, p. 597-608, 2018.
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