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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
15/12/2011 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, M. V. G. B.; SOSTENGARD, T. S.; HANOTTE, O.; MUGAMBI, J. M.; GARCIA, J. F.; NAGDA, S.; GIBSON, J. P.; IRAQI, F. A.; McCLINTOCK, A. E.; KEMP, S. J.; BOETTCHER, P. J.; MALEK, M.; TASSELL, C. P. Van; BAKER, R. L. |
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Afiliação: |
MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; TAD S. SOSTENGARD, USDA; O. HANOTTE, International Livestock Research Institute; J. M. MUGAMBI, International Livestock Research Institute; J. F. GARCIA, UNESP; FAO; S. NAGDA, International Livestock Research Institute; J. P. GIBSON, International Livestock Research Institute; University of New England Armidale; F. A. IRAQI, International Livestock Research Institute; Tel Aviv University; A. E. McCLINTOCK, International Livestock Research Institute; S. J. KEMP, International Livestock Research Institute; P. J. BOETTCHER, FAO/IAEA; M. MALEK, FAO/IAEA; C. P. Van TASSEL, USDA; R. L. BAKER, International Livestock Research Institute. |
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Título: |
Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Animal Genetics, v. 43, n. 1, p. 63-71, 2012. |
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DOI: |
https://doi.org/10.1111/j.1365-2052.2011.02202.x |
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Idioma: |
Inglês |
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Conteúdo: |
A genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F(1) rams. This design provided an opportunity to map potentially unique genetic variation associated with a parasite-tolerant breed like Red Maasai, a breed developed to survive East African grazing conditions. Parasite indicator phenotypes (blood packed cell volume - PCV and faecal egg count - FEC) were collected on a weekly basis from 1064 lambs during a single 3-month post-weaning grazing challenge on infected pastures. The averages of last measurements for FEC (AVFEC) and PCV (AVPCV), along with decline in PCV from challenge start to end (PCVD), were used to select lambs (N = 371) for genotyping that represented the tails (10% threshold) of the phenotypic distributions. Marker genotypes for 172 microsatellite loci covering 25 of 26 autosomes (1560.7 cm) were scored and corrected by Genoprob prior to qxpak analysis that included Box-Cox transformed AVFEC and arcsine transformed PCV statistics. Significant QTL for AVFEC and AVPCV were detected on four chromosomes, and this included a novel AVFEC QTL on chromosome 6 that would have remained undetected without Box-Cox transformation methods. The most significant P-values for AVFEC, AVPCV and PCVD overlapped the same marker interval on chromosome 22, suggesting the potential for a single causative mutation, which remains unknown. In all cases, the favourable QTL allele was always contributed from Red Maasai, providing support for the idea that future marker-assisted selection for genetic improvement of production in East Africa will rely on markers in linkage disequilibrium with these QTL. MenosA genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F(1) rams. This design provided an opportunity to map potentially unique genetic variation associated with a parasite-tolerant breed like Red Maasai, a breed developed to survive East African grazing conditions. Parasite indicator phenotypes (blood packed cell volume - PCV and faecal egg count - FEC) were collected on a weekly basis from 1064 lambs during a single 3-month post-weaning grazing challenge on infected pastures. The averages of last measurements for FEC (AVFEC) and PCV (AVPCV), along with decline in PCV from challenge start to end (PCVD), were used to select lambs (N = 371) for genotyping that represented the tails (10% threshold) of the phenotypic distributions. Marker genotypes for 172 microsatellite loci covering 25 of 26 autosomes (1560.7 cm) were scored and corrected by Genoprob prior to qxpak analysis that included Box-Cox transformed AVFEC and arcsine transformed PCV statistics. Significant QTL for AVFEC and AVPCV were detected on four chromosomes, and this included a novel AVFEC QTL on chromosome 6 that would have remained undetected without Box-Cox transformation methods. The most significant P-values for AVFEC, AVPCV and PCVD overlapped the same marker interval on chromosome 22, suggesting the potential for a single causative mutation, which remains ... Mostrar Tudo |
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Palavras-Chave: |
East Africa; Gastrointestinal parasites. |
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Thesaurus Nal: |
marker-assisted selection; quantitative trait loci; sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02864naa a2200349 a 4500
001 1909953
005 2024-02-05
008 2012 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/j.1365-2052.2011.02202.x$2DOI
100 1 $aSILVA, M. V. G. B.
245 $aIdentification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep.$h[electronic resource]
260 $c2012
520 $aA genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F(1) rams. This design provided an opportunity to map potentially unique genetic variation associated with a parasite-tolerant breed like Red Maasai, a breed developed to survive East African grazing conditions. Parasite indicator phenotypes (blood packed cell volume - PCV and faecal egg count - FEC) were collected on a weekly basis from 1064 lambs during a single 3-month post-weaning grazing challenge on infected pastures. The averages of last measurements for FEC (AVFEC) and PCV (AVPCV), along with decline in PCV from challenge start to end (PCVD), were used to select lambs (N = 371) for genotyping that represented the tails (10% threshold) of the phenotypic distributions. Marker genotypes for 172 microsatellite loci covering 25 of 26 autosomes (1560.7 cm) were scored and corrected by Genoprob prior to qxpak analysis that included Box-Cox transformed AVFEC and arcsine transformed PCV statistics. Significant QTL for AVFEC and AVPCV were detected on four chromosomes, and this included a novel AVFEC QTL on chromosome 6 that would have remained undetected without Box-Cox transformation methods. The most significant P-values for AVFEC, AVPCV and PCVD overlapped the same marker interval on chromosome 22, suggesting the potential for a single causative mutation, which remains unknown. In all cases, the favourable QTL allele was always contributed from Red Maasai, providing support for the idea that future marker-assisted selection for genetic improvement of production in East Africa will rely on markers in linkage disequilibrium with these QTL.
650 $amarker-assisted selection
650 $aquantitative trait loci
650 $asheep
653 $aEast Africa
653 $aGastrointestinal parasites
700 1 $aSOSTENGARD, T. S.
700 1 $aHANOTTE, O.
700 1 $aMUGAMBI, J. M.
700 1 $aGARCIA, J. F.
700 1 $aNAGDA, S.
700 1 $aGIBSON, J. P.
700 1 $aIRAQI, F. A.
700 1 $aMcCLINTOCK, A. E.
700 1 $aKEMP, S. J.
700 1 $aBOETTCHER, P. J.
700 1 $aMALEK, M.
700 1 $aTASSELL, C. P. Van
700 1 $aBAKER, R. L.
773 $tAnimal Genetics$gv. 43, n. 1, p. 63-71, 2012.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
13/10/2020 |
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Data da última atualização: |
13/10/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SOARES, M. P.; CARDOSO, I. L.; ISHIKAWA, M. M.; OLIVEIRA, A. da S. S. de; SARTORATTO, A.; JONSSON, C. M.; QUEIROZ, S. C. do N. de; DUARTE, M. C. T.; RANTIN, F. T.; SAMPAIO, F. G. |
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Afiliação: |
MICHELLY PEREIRA SOARES, UFSCar; ISRAEL LUZ CARDOSO, UFSCar; MARCIA MAYUMI ISHIKAWA, CNPMA; ADRIANA DA SILVA SANTOS DE OLIVEIRA, CPQBA; ADILSON SARTORATTO, CPQBA; CLAUDIO MARTIN JONSSON, CNPMA; SONIA CLAUDIA DO N DE QUEIROZ, CNPMA; MARTA CRISTINA TEIXEIRA DUARTE, CPQBA; FRANCISCO TADEU RANTIN, UFSCar; FERNANDA GARCIA SAMPAIO, CNPMA. |
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Título: |
Effects of Artemisia annua alcohol extract on physiological and innate immunity of Nile tilapia (Oreochromis niloticus) to improve health status. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Fish and Shellfish Immunology, v. 105, p. 369-377, 2020. |
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ISSN: |
1050-4648 |
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DOI: |
https://doi.org/10.1016/j.fsi.2020.07.035 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Plants are a potential source of active molecules and are environmentally safer and cheaper than synthetic antibiotics. Bioactive compounds of Artemisia annua have shown pharmacological activities and are used globally as a supplement. The present study tested whether dietary supplementation with alcohol extract of the plant A. annua (ae-Aa; patent BR10201902707) improves the health status of juvenile Nile tilapia and increases resistance to diseases when fish are challenged with the bacteria Aeromonas hydrophila. The experimental design was completely randomized with four experimental groups (0.0, 0.1, 0.25, and 0.5% ae-Aa in the diets) with five repetitions (12 fish per repetition/experimental unit). We assessed serum glucose and cortisol levels in plasma, leukocyte respiratory activity, total plasma protein, serum lysozyme levels, as well as the number of circulating red blood cells and fish leukocytes at the end of the 30 days of feeding (phase I) and 24h after exposure to bacteria (phase II). The levels of lipid peroxidation, catalase activity and glutathione S-transferase of fish were also analyzed. The supplementation of 0.5% of ae-Aa was sufficient to increase the respiratory burst of leukocyte and lysozyme activity, total plasma protein, blood thrombocytes, neutrophils and monocytes after bacterial challenge (P < 0.05), and minimized stress response with decreases in plasmatic glucose and cortisol, and reduction in lipid peroxidation levels (P < 0.05). Results of the present study suggest that ae-Aa as a dietary supplement has benefits, including supplementation with 0.5% A. annua extract for 30 days to minimize the stress response and modulate innate immunity in Nile tilapia, providing fish with greater resistance and disease protection. MenosAbstract: Plants are a potential source of active molecules and are environmentally safer and cheaper than synthetic antibiotics. Bioactive compounds of Artemisia annua have shown pharmacological activities and are used globally as a supplement. The present study tested whether dietary supplementation with alcohol extract of the plant A. annua (ae-Aa; patent BR10201902707) improves the health status of juvenile Nile tilapia and increases resistance to diseases when fish are challenged with the bacteria Aeromonas hydrophila. The experimental design was completely randomized with four experimental groups (0.0, 0.1, 0.25, and 0.5% ae-Aa in the diets) with five repetitions (12 fish per repetition/experimental unit). We assessed serum glucose and cortisol levels in plasma, leukocyte respiratory activity, total plasma protein, serum lysozyme levels, as well as the number of circulating red blood cells and fish leukocytes at the end of the 30 days of feeding (phase I) and 24h after exposure to bacteria (phase II). The levels of lipid peroxidation, catalase activity and glutathione S-transferase of fish were also analyzed. The supplementation of 0.5% of ae-Aa was sufficient to increase the respiratory burst of leukocyte and lysozyme activity, total plasma protein, blood thrombocytes, neutrophils and monocytes after bacterial challenge (P < 0.05), and minimized stress response with decreases in plasmatic glucose and cortisol, and reduction in lipid peroxidation levels (P < 0.05). Res... Mostrar Tudo |
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Palavras-Chave: |
Bacterial challenge; Herbal immunostimulants. |
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Thesagro: |
Artemísia; Artemisia Annua; Imunologia; Tilápia Nilótica. |
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Thesaurus NAL: |
Artemisinin; Oxidative stress; Tilapia (common name). |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02924naa a2200361 a 4500
001 2125464
005 2020-10-13
008 2020 bl uuuu u00u1 u #d
022 $a1050-4648
024 7 $ahttps://doi.org/10.1016/j.fsi.2020.07.035$2DOI
100 1 $aSOARES, M. P.
245 $aEffects of Artemisia annua alcohol extract on physiological and innate immunity of Nile tilapia (Oreochromis niloticus) to improve health status.$h[electronic resource]
260 $c2020
520 $aAbstract: Plants are a potential source of active molecules and are environmentally safer and cheaper than synthetic antibiotics. Bioactive compounds of Artemisia annua have shown pharmacological activities and are used globally as a supplement. The present study tested whether dietary supplementation with alcohol extract of the plant A. annua (ae-Aa; patent BR10201902707) improves the health status of juvenile Nile tilapia and increases resistance to diseases when fish are challenged with the bacteria Aeromonas hydrophila. The experimental design was completely randomized with four experimental groups (0.0, 0.1, 0.25, and 0.5% ae-Aa in the diets) with five repetitions (12 fish per repetition/experimental unit). We assessed serum glucose and cortisol levels in plasma, leukocyte respiratory activity, total plasma protein, serum lysozyme levels, as well as the number of circulating red blood cells and fish leukocytes at the end of the 30 days of feeding (phase I) and 24h after exposure to bacteria (phase II). The levels of lipid peroxidation, catalase activity and glutathione S-transferase of fish were also analyzed. The supplementation of 0.5% of ae-Aa was sufficient to increase the respiratory burst of leukocyte and lysozyme activity, total plasma protein, blood thrombocytes, neutrophils and monocytes after bacterial challenge (P < 0.05), and minimized stress response with decreases in plasmatic glucose and cortisol, and reduction in lipid peroxidation levels (P < 0.05). Results of the present study suggest that ae-Aa as a dietary supplement has benefits, including supplementation with 0.5% A. annua extract for 30 days to minimize the stress response and modulate innate immunity in Nile tilapia, providing fish with greater resistance and disease protection.
650 $aArtemisinin
650 $aOxidative stress
650 $aTilapia (common name)
650 $aArtemísia
650 $aArtemisia Annua
650 $aImunologia
650 $aTilápia Nilótica
653 $aBacterial challenge
653 $aHerbal immunostimulants
700 1 $aCARDOSO, I. L.
700 1 $aISHIKAWA, M. M.
700 1 $aOLIVEIRA, A. da S. S. de
700 1 $aSARTORATTO, A.
700 1 $aJONSSON, C. M.
700 1 $aQUEIROZ, S. C. do N. de
700 1 $aDUARTE, M. C. T.
700 1 $aRANTIN, F. T.
700 1 $aSAMPAIO, F. G.
773 $tFish and Shellfish Immunology$gv. 105, p. 369-377, 2020.
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