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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
18/09/2007 |
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Data da última atualização: |
06/01/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANDRADE-NETO, V. F. de; POHLIT, A. M.; PINTO, A. C. S.; SILVA, E. C. C.; NOGUEIRA, K. L.; MELO, M. R. S.; HENRIQUE, M. C.; AMORIM, R. C. N.; SILVA, L. F. R.; COSTA, M. R. F.; NUNOMURA, R. C. S.; NUNOMURA, S. M.; ALECRIM, W. D.; ALECRIM, M. das G. C.; CHAVES, F. C. M.; VIEIRA, P. P. R. |
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Afiliação: |
Valter F. de Andrade-Neto, Inpa; Adrian M. Pohlit, Inpa; Ana Cristina S. Pinto, Inpa/Ufam; Ellen Cristina C. Silva, Inpa/Ufam; Karla L. Nogueira, Inpa/CEFET-AM; Márcia R.S. Melo, Inpa/FMTM; Marycleuma C. Henrique, Inpa/Ufam; Rodrigo C.N. Amorim, Inpa/Ufam; Luis Francisco R. Silva, FMTM; Mônica R.F. Costa, FMTM; Rita C.S. Nunomura, Inpa; Sergio M. Nunomura, Inpa; Wilson D. Alecrim, FMTM; Maria das Graças C. Alecrim, Inpa/UniNilton Lins; Francisco Célio Maia Chaves, CPAA; Pedro Paulo R. Vieira, UEA. |
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Título: |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007. |
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Idioma: |
Inglês |
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Conteúdo: |
In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived. |
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Palavras-Chave: |
Isolação in vitro. |
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Thesagro: |
Planta. |
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Thesaurus Nal: |
Amazonia; malaria; Plasmodium falciparum. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/114925/1/5792.pdf
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Marc: |
LEADER 02028naa a2200361 a 4500
001 1681123
005 2015-01-06
008 2007 bl uuuu u00u1 u #d
100 1 $aANDRADE-NETO, V. F. de
245 $aIn vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.
260 $c2007
520 $aIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.
650 $aAmazonia
650 $amalaria
650 $aPlasmodium falciparum
650 $aPlanta
653 $aIsolação in vitro
700 1 $aPOHLIT, A. M.
700 1 $aPINTO, A. C. S.
700 1 $aSILVA, E. C. C.
700 1 $aNOGUEIRA, K. L.
700 1 $aMELO, M. R. S.
700 1 $aHENRIQUE, M. C.
700 1 $aAMORIM, R. C. N.
700 1 $aSILVA, L. F. R.
700 1 $aCOSTA, M. R. F.
700 1 $aNUNOMURA, R. C. S.
700 1 $aNUNOMURA, S. M.
700 1 $aALECRIM, W. D.
700 1 $aALECRIM, M. das G. C.
700 1 $aCHAVES, F. C. M.
700 1 $aVIEIRA, P. P. R.
773 $tMemórias do Instituto Oswaldo Cruz, Rio de Janeiro$gv. 102, n. 3, p. 359-365, jun. 2007.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
09/10/2020 |
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Data da última atualização: |
09/10/2020 |
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Tipo da produção científica: |
Nota Técnica/Nota Científica |
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Autoria: |
ÁVILA, S.; LAZZAROTTO, M.; HORNUNG, P. S.; TEIXEIRA, G. L.; ITO, V. C.; BELLETTINI, M. B.; BEUX, M. R.; BETA, T.; RIBAN, R. H. |
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Afiliação: |
Suelen Ávila, UFPR; MARCELO LAZZAROTTO, CNPF; Polyanna Silveira Hornung, UFPR; Gerson Lopes Teixeira, UFSC; Vivian Cristina Ito, UEPG; Marcelo Barba Bellettini, UFPR; Márcia Regina Beux, UFPR; Trust Beta, University of Manitoba; Rosemary Hoffmann Riban, UFPR. |
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Título: |
Influence of stingless bee genus (Scaptotrigona and Melipona) on the mineral content, physicochemical and microbiological properties of honey. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Journal of Food Science and Technology, v. 56, n. 10, p. 4742-4748, Oct. 2019. |
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DOI: |
https://doi.org/10.1007/s13197-019-03939-8 |
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Idioma: |
Inglês |
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Notas: |
Sort communication. |
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Conteúdo: |
Stingless bees, important pollinating insects in the tropics, produce honey whose unique quality features differentiate their origin. The feasibility of multivariate data analysis for quality discrimination of stingless bee honey from different genera (Melipona bicolor, quadrifasciata, marginata and Scaptotrigona bipunctata) by mineral content, physicochemical and microbiological properties were investigated. The principal component analysis explained 72.12% of the total variance of the data, and the separation into two main groups in a scatter plot was observed. Group 2 was formed by Scaptotrigona genus, that showed the highest values of pH, ash, and soluble solids. Potassium was the most abundant mineral followed by calcium and sodium for both groups quantified by inductively coupled plasma optical emission spectrometry. This honey has higher acidity and moisture than Apis mellifera honey. Microbiological analyses showed that total aerobic mesophiles ranged between 2.00 and 4.77 log CFU/g. Salmonella spp. was not detected, while the mould and yeast content was above the maximum allowed under the Apis mellifera honey legislation. The evaluated honey samples presented the lactic acid bacteria, which are considered a benefit. The multivariate statistical analysis was efficient in discriminate stingless bee honey, contributing to approaches that can be used for standardization and regulation. |
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Palavras-Chave: |
Abeha sem ferrão; Hierarchical cluster analysis. |
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Thesagro: |
Mel. |
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Thesaurus NAL: |
Chemometrics; Honey; Melipona; Principal component analysis; Scaptotrigona. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 02465naa a2200337 a 4500
001 2125396
005 2020-10-09
008 2019 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s13197-019-03939-8$2DOI
100 1 $aÁVILA, S.
245 $aInfluence of stingless bee genus (Scaptotrigona and Melipona) on the mineral content, physicochemical and microbiological properties of honey.$h[electronic resource]
260 $c2019
500 $aSort communication.
520 $aStingless bees, important pollinating insects in the tropics, produce honey whose unique quality features differentiate their origin. The feasibility of multivariate data analysis for quality discrimination of stingless bee honey from different genera (Melipona bicolor, quadrifasciata, marginata and Scaptotrigona bipunctata) by mineral content, physicochemical and microbiological properties were investigated. The principal component analysis explained 72.12% of the total variance of the data, and the separation into two main groups in a scatter plot was observed. Group 2 was formed by Scaptotrigona genus, that showed the highest values of pH, ash, and soluble solids. Potassium was the most abundant mineral followed by calcium and sodium for both groups quantified by inductively coupled plasma optical emission spectrometry. This honey has higher acidity and moisture than Apis mellifera honey. Microbiological analyses showed that total aerobic mesophiles ranged between 2.00 and 4.77 log CFU/g. Salmonella spp. was not detected, while the mould and yeast content was above the maximum allowed under the Apis mellifera honey legislation. The evaluated honey samples presented the lactic acid bacteria, which are considered a benefit. The multivariate statistical analysis was efficient in discriminate stingless bee honey, contributing to approaches that can be used for standardization and regulation.
650 $aChemometrics
650 $aHoney
650 $aMelipona
650 $aPrincipal component analysis
650 $aScaptotrigona
650 $aMel
653 $aAbeha sem ferrão
653 $aHierarchical cluster analysis
700 1 $aLAZZAROTTO, M.
700 1 $aHORNUNG, P. S.
700 1 $aTEIXEIRA, G. L.
700 1 $aITO, V. C.
700 1 $aBELLETTINI, M. B.
700 1 $aBEUX, M. R.
700 1 $aBETA, T.
700 1 $aRIBAN, R. H.
773 $tJournal of Food Science and Technology$gv. 56, n. 10, p. 4742-4748, Oct. 2019.
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Embrapa Florestas (CNPF) |
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