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1. | | FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006. Biblioteca(s): Embrapa Amazônia Ocidental. |
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Registros recuperados : 1 | |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Amazônia Ocidental. |
Data corrente: |
19/09/2006 |
Data da última atualização: |
06/01/2015 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
Internacional - A |
Autoria: |
FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. |
Afiliação: |
H. Fukumasu, USP; J.L. Avanzo, USP; R. Heidor, USP; T.C. Silva, USP; André Atroch, CPAA; F.S. Moreno, USP; M.L.Z. Dagli, USP. |
Título: |
Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. |
Ano de publicação: |
2006 |
Fonte/Imprenta: |
Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006. |
Idioma: |
Inglês |
Conteúdo: |
Guarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver. |
Thesagro: |
DNA; Guaraná; Paullinia Cupana. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01880naa a2200229 a 4500 001 1678895 005 2015-01-06 008 2006 bl uuuu u00u1 u #d 100 1 $aFUKUMASU, H. 245 $aProtective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. 260 $c2006 520 $aGuarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver. 650 $aDNA 650 $aGuaraná 650 $aPaullinia Cupana 700 1 $aAVANZO, J. L. 700 1 $aHEIDOR, R. 700 1 $aSILVA, T. C. 700 1 $aATROCH, A. 700 1 $aMORENO, F. S. 700 1 $aDAGLI, M. L. Z. 773 $tFood and Chemical Toxicology$gv. 44, n. 6 , p. 862-867, jun. 2006.
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Embrapa Amazônia Ocidental (CPAA) |
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