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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
26/10/2009 |
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Data da última atualização: |
16/08/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GONÇALVES, K. N.; ANDREOTTI, R.; PAIVA, F.; PONTES, E. R. J. C.; LIMA JUNIOR, M. S. da C.; OSHIRO, L. M.; MATOS, M. de F. C. |
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Afiliação: |
KELLY N. GONÇALVES, UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL; RENATO ANDREOTTI E SILVA, CNPGC; FERNANDO PAIVA, UNIVERSIDADEE FEDERAL DE MATO GROSSO DO SUL; ELENIR ROSE JARDIM CURY PONTES, UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL; MANOEL SEBASTIÃO DA COSTA LIMA JUNIOR, UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL; LEANDRA MARLA OSHIRO, UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL; MARIA DE FATIMA CEPA MATOS, UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL. |
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Título: |
Interleukin-12 response to NCSRS2 immunization of BALB/C mice against Neospora caninum. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
Revista Brasileira de Parasitologia Veterinária, v. 17, p. 215-219, 2008. Suplemento 1. |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Renato Andreotti. |
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Conteúdo: |
The apicomplexan parasite Neospora caninum can cause abortions and is recognized as an important causative agent responsible for economic and reproductive losses in the cattle industry. Humoral immune response was investigated in BALB/c mice by using recombinant NcSRS2 expressed in Escherichia coli as polyhistidine-tagged fusion proteins. NcSRS2 is the major immunodominant tachyzoite surface antigen of N. caninum. Separate groups of female BALB/c mice were infected subcutaneously with (P) PBS, (N) recNcSRS2, (NIL) recNcSRS2 plus interleukin-12 or (NF) recNcSRS2, in Freund?s adjuvant. Serological analysis showed that the antibodies produced by immunization recognized native protein from N. caninum tachyzoites and that, 14 days after the initial immunization, NcSRS2-specific antibodies were present in all sera tested from the groups N, NIL and NF. NcSRS2 with Freud?s adjuvant led to a stronger immune response, as measured by IgG1 and IgG2a levels, than did other formulations (NF > NIL > N > P; p < 0.001), with a Th2 bias. The results corroborate the potential use of recombinant protein NcSRS2 as a vaccine aimed at reducing congenital transmission. Further studies are required to identify new adjuvants capable of improving the induction of Th1 immune response. |
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Thesagro: |
Escherichia Coli; Neospora Caninum; Neosporose; Parasito de Animal; Sanidade Animal; Vacina. |
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Thesaurus Nal: |
Animal health; Animal parasites and pests; Immune response; Neosporosis; Vaccines. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/573257/1/Interleukin-12-response-NCSRS2-2008.pdf
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Marc: |
LEADER 02278naa a2200337 a 4500
001 1573257
005 2023-08-16
008 2008 bl uuuu u00u1 u #d
100 1 $aGONÇALVES, K. N.
245 $aInterleukin-12 response to NCSRS2 immunization of BALB/C mice against Neospora caninum.
260 $c2008
500 $aNa publicação: Renato Andreotti.
520 $aThe apicomplexan parasite Neospora caninum can cause abortions and is recognized as an important causative agent responsible for economic and reproductive losses in the cattle industry. Humoral immune response was investigated in BALB/c mice by using recombinant NcSRS2 expressed in Escherichia coli as polyhistidine-tagged fusion proteins. NcSRS2 is the major immunodominant tachyzoite surface antigen of N. caninum. Separate groups of female BALB/c mice were infected subcutaneously with (P) PBS, (N) recNcSRS2, (NIL) recNcSRS2 plus interleukin-12 or (NF) recNcSRS2, in Freund?s adjuvant. Serological analysis showed that the antibodies produced by immunization recognized native protein from N. caninum tachyzoites and that, 14 days after the initial immunization, NcSRS2-specific antibodies were present in all sera tested from the groups N, NIL and NF. NcSRS2 with Freud?s adjuvant led to a stronger immune response, as measured by IgG1 and IgG2a levels, than did other formulations (NF > NIL > N > P; p < 0.001), with a Th2 bias. The results corroborate the potential use of recombinant protein NcSRS2 as a vaccine aimed at reducing congenital transmission. Further studies are required to identify new adjuvants capable of improving the induction of Th1 immune response.
650 $aAnimal health
650 $aAnimal parasites and pests
650 $aImmune response
650 $aNeosporosis
650 $aVaccines
650 $aEscherichia Coli
650 $aNeospora Caninum
650 $aNeosporose
650 $aParasito de Animal
650 $aSanidade Animal
650 $aVacina
700 1 $aANDREOTTI, R.
700 1 $aPAIVA, F.
700 1 $aPONTES, E. R. J. C.
700 1 $aLIMA JUNIOR, M. S. da C.
700 1 $aOSHIRO, L. M.
700 1 $aMATOS, M. de F. C.
773 $tRevista Brasileira de Parasitologia Veterinária$gv. 17, p. 215-219, 2008. Suplemento 1.
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