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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
23/11/2011 |
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Data da última atualização: |
11/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SACHETTI, C. G.; CARVALHO, R. R. de; PAUMGARTTEN, F. J.; LAMEIRA, O. A.; CALDAS, E. D. |
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Afiliação: |
CAMILE G. SACHETTI, UNB; ROSÂNGELA R. DE CARVALHO, FUNDAÇÃO OSWALDO CRUZ; FRANCISCO J. R. PAUMGARTTEN, FUNDAÇÃO OSWALDO CRUZ; OSMAR ALVES LAMEIRA, CPATU; ELOISA D. CALDAS, UNB. |
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Título: |
Developmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Food and chemical toxicology, v. 49, n. 5, p. 1080-1085, 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
The oleoresin of the copaiba tree (Copaifera sp., Fabaceae) is traditionally used in Brazilian herbal medicine to treat a variety of illnesses and symptoms. This study, conducted according to the OECD Guideline 414, provides data on the developmental toxicity of oleoresin from C. reticulata (COPA-R) in rats. Pregnant Wistar rats (25 per dose group) were treated by gavage with COPA-R (0, 500, 1000 and 1250 mg/kg bw/day) on gestation days (GD) 6?19 and Caesarean sections performed on GD20. Implantations, living and dead fetuses and resorptions were recorded. Half of the fetuses from each litter were examined for visceral abnormalities and the remaining were cleared and stained for skeleton evaluation. COPA-R was maternally toxic (reduced food intake and weight gain) and embryotoxic (lower fetal body weight and increased occurrence of fetal skeleton variations) at the two highest doses, but did not cause embryo deaths or fetal malformations at any dose level. The study derived an oral no-observed-adverse-effectlevel (NOAEL) for maternal and developmental toxicity induced by COPA-R of 500 mg/kg bw/day. The results suggest that copaiba oleoresin does not pose a health risk to pregnant women when used according to the recommended doses (up to five drops, three times a day). |
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Palavras-Chave: |
Copaifera reticulata. |
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Thesagro: |
Arvore angiosperma; Copaiba; Planta medicinal. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01954naa a2200217 a 4500
001 1906830
005 2022-11-11
008 2011 bl uuuu u00u1 u #d
100 1 $aSACHETTI, C. G.
245 $aDevelopmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat.$h[electronic resource]
260 $c2011
520 $aThe oleoresin of the copaiba tree (Copaifera sp., Fabaceae) is traditionally used in Brazilian herbal medicine to treat a variety of illnesses and symptoms. This study, conducted according to the OECD Guideline 414, provides data on the developmental toxicity of oleoresin from C. reticulata (COPA-R) in rats. Pregnant Wistar rats (25 per dose group) were treated by gavage with COPA-R (0, 500, 1000 and 1250 mg/kg bw/day) on gestation days (GD) 6?19 and Caesarean sections performed on GD20. Implantations, living and dead fetuses and resorptions were recorded. Half of the fetuses from each litter were examined for visceral abnormalities and the remaining were cleared and stained for skeleton evaluation. COPA-R was maternally toxic (reduced food intake and weight gain) and embryotoxic (lower fetal body weight and increased occurrence of fetal skeleton variations) at the two highest doses, but did not cause embryo deaths or fetal malformations at any dose level. The study derived an oral no-observed-adverse-effectlevel (NOAEL) for maternal and developmental toxicity induced by COPA-R of 500 mg/kg bw/day. The results suggest that copaiba oleoresin does not pose a health risk to pregnant women when used according to the recommended doses (up to five drops, three times a day).
650 $aArvore angiosperma
650 $aCopaiba
650 $aPlanta medicinal
653 $aCopaifera reticulata
700 1 $aCARVALHO, R. R. de
700 1 $aPAUMGARTTEN, F. J.
700 1 $aLAMEIRA, O. A.
700 1 $aCALDAS, E. D.
773 $tFood and chemical toxicology$gv. 49, n. 5, p. 1080-1085, 2011.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Corte; Embrapa Gado de Leite. |
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Data corrente: |
06/09/2022 |
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Data da última atualização: |
14/12/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SILVA, M. R.; DUCH, A. A. S.; LAGE, R. T. P. de A.; FARIA, L. S. de; MENEZES, L. D. M.; RIBEIRO, J. B.; SOUZA, G. N. de; SOARES FILHO, P. M.; PREIS, I. S.; SALES, E. B.; SOUZA, P. G. de; ARAUJO, F. R.; GUIMARÃES, R. J. de P. S. e; MENDES, T.; PETTAN-BREWER, C.; FONSECA-JÚNIOR, A. A. |
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Afiliação: |
MARCIO ROBERTO SILVA, CNPGL; ANDRÉ ALMEIDA SANTOS DUCH, Instituto Mineiro de Agricultura e Pecuária; RÔMULO TADEU PACE DE ASSIS LAGE, Instituto Mineiro de Agricultura e Pecuária; LETÍCIA SCAFUTTO DE FARIA; LILIANE DENIZE MIRANDA MENEZES, Instituto Mineiro de Agricultura e Pecuária; JOAO BATISTA RIBEIRO, CNPGL; GUILHERME NUNES DE SOUZA, CNPGL; PAULO MARTINS SOARES FILHO; INGRED SALES PREIS; ÉRICA BRAVO SALES; PATRÍCIA GOMES DE SOUZA; FLABIO RIBEIRO DE ARAUJO, CNPGC; RICARDO JOSÉ DE PAULA SOUZA E GUIMARÃES, Instituto Evandro Chagas; TULIO MENDES, Marinha do Brasil; CHRISTINA PETTAN-BREWER, University of Washington; ANTÔNIO AUGUSTO FONSECA-JÚNIOR. |
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Título: |
Recovery of Brucella in raw milk Minas artisanal cheese approved for consumption by official inspection agency in Brazil: assessment of prevalence and risk factors through One Health integrated approaches. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Transactions of The Royal Society of Tropical Medicine and Hygiene, trac083, 2022. |
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DOI: |
https://doi.org/10.1093/trstmh/trac083 |
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Idioma: |
Inglês |
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Conteúdo: |
Background - Minas artisanal cheese (MAC) from the Serro region is a Brazilian intangible cultural heritage. Produced from raw milk, it may carry zoonotic pathogens such as Brucella. This study included a randomized survey for the prevalence of Brucella-positive MAC and its associated factors. Methods - MAC samples (n=55), each one from a different rural family-based cheese-processing agroindustry, were analysed for Brucella by direct polymerase chain reaction (PCR) species-specific DNA detection and cultivation-based approaches. Results - Among 55 MACs that were analysed, we found 17 Brucella DNA-positive samples (30.9% [95% confidence interval {CI} 18.7 to 43.1]) by PCR and, for the first time, from one MAC (1.8% [95% CI 0.5 to 9.7]), viable Brucella abortus was recovered by cultivation. Higher values for two variables, the number of lactating cows per herd (p=0.043) and daily milk production per herd (p=0.043), were each associated with Brucella-positive MAC, which concentrated in three high-risk and one low-risk spatial clusters.
Conclusions - MAC may be a source of Brucella for humans, since the positive samples were from batches that were sold by cheesemakers. This should be of concern and encourage cooperation between the health and agriculture sectors in order to mitigate this public health risk through One Health integrated approaches. |
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Palavras-Chave: |
Leite cru. |
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Thesagro: |
Brucella Abortus; Leite; Patógeno; Queijo de Minas. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02597naa a2200373 a 4500
001 2146141
005 2022-12-14
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1093/trstmh/trac083$2DOI
100 1 $aSILVA, M. R.
245 $aRecovery of Brucella in raw milk Minas artisanal cheese approved for consumption by official inspection agency in Brazil$bassessment of prevalence and risk factors through One Health integrated approaches.$h[electronic resource]
260 $c2022
520 $aBackground - Minas artisanal cheese (MAC) from the Serro region is a Brazilian intangible cultural heritage. Produced from raw milk, it may carry zoonotic pathogens such as Brucella. This study included a randomized survey for the prevalence of Brucella-positive MAC and its associated factors. Methods - MAC samples (n=55), each one from a different rural family-based cheese-processing agroindustry, were analysed for Brucella by direct polymerase chain reaction (PCR) species-specific DNA detection and cultivation-based approaches. Results - Among 55 MACs that were analysed, we found 17 Brucella DNA-positive samples (30.9% [95% confidence interval {CI} 18.7 to 43.1]) by PCR and, for the first time, from one MAC (1.8% [95% CI 0.5 to 9.7]), viable Brucella abortus was recovered by cultivation. Higher values for two variables, the number of lactating cows per herd (p=0.043) and daily milk production per herd (p=0.043), were each associated with Brucella-positive MAC, which concentrated in three high-risk and one low-risk spatial clusters. Conclusions - MAC may be a source of Brucella for humans, since the positive samples were from batches that were sold by cheesemakers. This should be of concern and encourage cooperation between the health and agriculture sectors in order to mitigate this public health risk through One Health integrated approaches.
650 $aBrucella Abortus
650 $aLeite
650 $aPatógeno
650 $aQueijo de Minas
653 $aLeite cru
700 1 $aDUCH, A. A. S.
700 1 $aLAGE, R. T. P. de A.
700 1 $aFARIA, L. S. de
700 1 $aMENEZES, L. D. M.
700 1 $aRIBEIRO, J. B.
700 1 $aSOUZA, G. N. de
700 1 $aSOARES FILHO, P. M.
700 1 $aPREIS, I. S.
700 1 $aSALES, E. B.
700 1 $aSOUZA, P. G. de
700 1 $aARAUJO, F. R.
700 1 $aGUIMARÃES, R. J. de P. S. e
700 1 $aMENDES, T.
700 1 $aPETTAN-BREWER, C.
700 1 $aFONSECA-JÚNIOR, A. A.
773 $tTransactions of The Royal Society of Tropical Medicine and Hygiene, trac083, 2022.
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