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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Corte. Para informações adicionais entre em contato com biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Corte. |
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Data corrente: |
17/07/2018 |
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Data da última atualização: |
27/09/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANDREOTTI, R.; GIACHETTO, P. F.; CUNHA, R. C. |
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Afiliação: |
RENATO ANDREOTTI E SILVA, CNPGC; POLIANA FERNANDA GIACHETTO, CNPTIA; RODRIGO CASQUERO CUNHA, Bolsista PNPD/Capes. |
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Título: |
Advances in tick vaccinology in Brazil: from gene expression to immunoprotection. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Frontiers in Bioscience - Scholar, v. 10, n. 1, p. 127-142, Jan. 2018 |
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Idioma: |
Inglês |
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Conteúdo: |
Rhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis. |
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Thesagro: |
Vacina. |
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Thesaurus Nal: |
Gene expression; Rhipicephalus microplus; Transcriptome; Vaccines. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01823naa a2200205 a 4500
001 2093371
005 2018-09-27
008 2018 bl uuuu u00u1 u #d
100 1 $aANDREOTTI, R.
245 $aAdvances in tick vaccinology in Brazil$bfrom gene expression to immunoprotection.$h[electronic resource]
260 $c2018
520 $aRhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis.
650 $aGene expression
650 $aRhipicephalus microplus
650 $aTranscriptome
650 $aVaccines
650 $aVacina
700 1 $aGIACHETTO, P. F.
700 1 $aCUNHA, R. C.
773 $tFrontiers in Bioscience - Scholar$gv. 10, n. 1, p. 127-142, Jan. 2018
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