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| Registros recuperados : 26 | |
| 4. |  | RIBEIRO, L. A. O.; FONTANA, C. S.; WALD, V. B.; GREGORY, R. M.; MATTOS, R. C. Relação entre a condição corporal e a idade das ovelhas no encarneiramento com a prenhez. Ciência Rural, Santa Maria, v. 33, n. 2, p. 357-361, 2003.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 5. | | GIORGI, V.; BOTTO, E.; FONTANA, C.; MEA, L. D.; VAZ JUNIOR, S.; MENÉNDEZ, P.; RODRÍGUEZ, P. Enzymatic Production of Lauroyl and Stearoyl Monoesters of D-Xylose, L-Arabinose, and D-Glucose as Potential Lignocellulosic-Derived Products, and Their Evaluation as Antimicrobial Agents. Catalysts, v.12, n. 610, 2022.| Biblioteca(s): Embrapa Agroenergia. |
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| 7. | | FONTANA, C.; REIS-AVILA, G.; NABAIS, C.; BOTOSSO, P. C.; OLIVEIRA, J. M. Dendrochronology and climate in the Brazilian Atlantic Forest: which species, where and how Neotropical Biology and Conservation, v. 13, n. 4, p. 321-333, Oct./Dec. 2018. Artigo de revisão.| Biblioteca(s): Embrapa Florestas. |
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| 10. | | FONTANA, C.; SANTINI-JUNIOR, L.; SILVA, C. A. da; OLIVEIRA, J. M.; TOMAZELLO-FILHO, M.; BOTOSSO, P. C. Dendroecology and wood anatomy of a rare species Dinizia jueirana-facao (Fabaceae), "Tabuleiros" Atlantic Forest, Brazil. Pesquisa Florestal Brasileira, Colombo, v. 39, (nesp), e201902043, 2019. p. 241. Edição especial dos resumos do IUFRO World Congress, 25., 2019, Curitiba.| Biblioteca(s): Embrapa Florestas. |
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| 12. | | FONTANA, C.; SANTINI-JUNIOR, L.; OLMEDO, G. M.; BOTOSSO, P. C.; TOMAZELLO-FILHO, M.; OLIVEIRA, J. M. Assessment of the dendrochronological potential of Licaria bahiana Kurz, an endemic laurel of lowland Atlantic forests in Brazil. Acta Botanica Brasilica, v. 33, n. 3, p. 454-464. July/Sept. 2019.| Biblioteca(s): Embrapa Florestas. |
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| 13. | | FONTANA, C.; SANTINI JUNIOR, L.; SILVA, C. A. da; OLIVEIRA, J. M.; TOMAZELLO-FILHO, M.; BOTOSSO, P. C. Wood anatomy of the rare species Dinizia jueirana-facao (Fabaceae), "Tabuleiros" Atlantic Forest, Brazil. Brazilian Journal of Botany, v. 42, n. 3, p. 521-528, Sept. 2019.| Biblioteca(s): Embrapa Florestas. |
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| 14. | | FONTANA, C.; PÉREZ-DE-LIS, G.; NABAIS, C.; LOUSADA, J. L. P. C.; OLMEDO, G. M.; BOTOSSO, P. C.; OLIVEIRA, J. M. Climatic signal in growth-rings of Copaifera lucens: an endemic species of a Brazilian Atlantic forest hotspot, southeastern Brazil. Dendrochronologia, v. 50, p. 23-32, Aug. 2018.| Biblioteca(s): Embrapa Florestas. |
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| 16. | | FONTANA, C. A. P.; MACHADO, M, R. F.; VIU, M. A. O.; FONTANA, V. L. D. S.; SOUSA, A. P. F.; FERRAZ, H. T.; LOPES, D. T. Correlações entre medidas corporais e biometria da articulação coxo-femural e ligamento "Capitis femoris" em borregos Santa Inês. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 43., 2006, João Pessoa. Produção animal em biomas tropicais: anais dos simpósios. João Pessoa: Sociedade Brasileira de Zootecnia, 2006. 4 f.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 17. | | FONTANA, C. A. P.; MACHADO, M, R. F.; VIU, M. A. O.; S. SOBRINHO, A. G.; FONTANA, V. L. D. S.; FERRAZ, H. T.; LOPES, D. T. Correlações entre peso vivo e medidas corporais em borregos Santa Inês. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 43., 2006, João Pessoa. Produção animal em biomas tropicais: anais dos simpósios. João Pessoa: Sociedade Brasileira de Zootecnia, 2006. 4 f.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 19. | | SANTOS, D. M.; CHAGAS, P. A. M.; LEITE, I. S.; INADA, N. M.; ANNUNZIO, S. R.; FONTANA, C. R.; CAMPANA-FILHO, S. P.; CORREA, D. S. Core-sheath nanostructured chitosan-based nonwovens as a potential drug delivery system for periodontitis treatment. International Journal of Biological Macromolecules, n.142 , 2020. 521 - 534| Biblioteca(s): Embrapa Instrumentação. |
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| 20. | | FONTANA, C.; PÉREZ-DE-LIZ, G.; SANTINI JUNIOR, L.; BOTOSSO, P. C.; NABAIS, C.; TOMAZELLO FILHO, M.; LOUSADA, J. L. P. C. Wood anatomy and growth ring boundaries of Copaifera lucens (Fabaceae). IAWA Journal, v. 39, n. 4, p. 395-405, 2018.| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 26 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
30/03/2022 |
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Data da última atualização: |
30/03/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 4 |
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Autoria: |
SANTOS, D. M. dos; ANNUNZIO, S. R. de; CARMELLO, J. C.; PAVARINA, A. C.; FONTANA, C. R.; CORREA, D. S. |
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Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Combining coaxial electrospinning and 3D printing: design of biodegradable bilayered membranes with dual drug delivery capability for periodontitis treatment. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
ACS Applied Bio Materials, v. 5, 2022. |
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Páginas: |
146−159 |
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DOI: |
https://doi.org/10.1021/acsabm.1c01019 |
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Idioma: |
Português |
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Conteúdo: |
Periodontitis is a chronic inflammatory disease that can lead to significant destruction of tooth-supporting tissues, compromising dental function and patient?s health. Although the currently employed treatment approaches can limit the advance of the disease, the development of multifunctional and hierarchically structured materials is still in demand for achieving successful tissue regeneration. Here, we combine coaxial electrospinning and 3D printing techniques to prepare bilayered zein-based membranes as a potential dual drug delivery platform for periodontal tissue regeneration. A layer of core−sheath electrospun nanofibers consisting of poly(ethylene oxide) (PEO)/curcumin (Curc)/ tetracycline hydrochloride (TH) as the core and zein/poly(ε-caprolactone)(PCL)/β-glycerolphosphate (β-GP) as the sheath was deposited over a 3D printed honeycomb PLA/zein/Curc platform in order to render a bilayered structure that can mimic the architecture of periodontal tissue. The physicochemical properties of engineered constructs as well as the release profiles of distinct drugs were mainly controlled by varying the concentration of zein (10, 20, 30%, w/w relative to dry PCL) on the sheath layer of nanofibers, which displayed average diameters ranging from 150 to 400 nm. In vitro experiments demonstrated that the bilayered constructs provided sustained release of distinct drugs over 8 days and exhibited biocompatibility toward human oral keratinocytes (Nok-si) (cell viability >80%) as well as antibacterial activity against distinct bacterial strains including those of the red complex such as Porphyromonas gingivalis and Treponema denticola, which are recognized to elicit aggressive and chronic periodontitis. Our study reveals the potential of zein-based bilayered membranes as a dual drug delivery platform for periodontal tissue regeneration. MenosPeriodontitis is a chronic inflammatory disease that can lead to significant destruction of tooth-supporting tissues, compromising dental function and patient?s health. Although the currently employed treatment approaches can limit the advance of the disease, the development of multifunctional and hierarchically structured materials is still in demand for achieving successful tissue regeneration. Here, we combine coaxial electrospinning and 3D printing techniques to prepare bilayered zein-based membranes as a potential dual drug delivery platform for periodontal tissue regeneration. A layer of core−sheath electrospun nanofibers consisting of poly(ethylene oxide) (PEO)/curcumin (Curc)/ tetracycline hydrochloride (TH) as the core and zein/poly(ε-caprolactone)(PCL)/β-glycerolphosphate (β-GP) as the sheath was deposited over a 3D printed honeycomb PLA/zein/Curc platform in order to render a bilayered structure that can mimic the architecture of periodontal tissue. The physicochemical properties of engineered constructs as well as the release profiles of distinct drugs were mainly controlled by varying the concentration of zein (10, 20, 30%, w/w relative to dry PCL) on the sheath layer of nanofibers, which displayed average diameters ranging from 150 to 400 nm. In vitro experiments demonstrated that the bilayered constructs provided sustained release of distinct drugs over 8 days and exhibited biocompatibility toward human oral keratinocytes (Nok-si) (cell vi... Mostrar Tudo |
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Palavras-Chave: |
Asymmetric membrane; Controlled release; Electrospinning; Hierarchical materials; Periodontal membrane. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02757naa a2200265 a 4500
001 2141634
005 2022-03-30
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsabm.1c01019$2DOI
100 1 $aSANTOS, D. M. dos
245 $aCombining coaxial electrospinning and 3D printing$bdesign of biodegradable bilayered membranes with dual drug delivery capability for periodontitis treatment.$h[electronic resource]
260 $c2022
300 $a146−159
520 $aPeriodontitis is a chronic inflammatory disease that can lead to significant destruction of tooth-supporting tissues, compromising dental function and patient?s health. Although the currently employed treatment approaches can limit the advance of the disease, the development of multifunctional and hierarchically structured materials is still in demand for achieving successful tissue regeneration. Here, we combine coaxial electrospinning and 3D printing techniques to prepare bilayered zein-based membranes as a potential dual drug delivery platform for periodontal tissue regeneration. A layer of core−sheath electrospun nanofibers consisting of poly(ethylene oxide) (PEO)/curcumin (Curc)/ tetracycline hydrochloride (TH) as the core and zein/poly(ε-caprolactone)(PCL)/β-glycerolphosphate (β-GP) as the sheath was deposited over a 3D printed honeycomb PLA/zein/Curc platform in order to render a bilayered structure that can mimic the architecture of periodontal tissue. The physicochemical properties of engineered constructs as well as the release profiles of distinct drugs were mainly controlled by varying the concentration of zein (10, 20, 30%, w/w relative to dry PCL) on the sheath layer of nanofibers, which displayed average diameters ranging from 150 to 400 nm. In vitro experiments demonstrated that the bilayered constructs provided sustained release of distinct drugs over 8 days and exhibited biocompatibility toward human oral keratinocytes (Nok-si) (cell viability >80%) as well as antibacterial activity against distinct bacterial strains including those of the red complex such as Porphyromonas gingivalis and Treponema denticola, which are recognized to elicit aggressive and chronic periodontitis. Our study reveals the potential of zein-based bilayered membranes as a dual drug delivery platform for periodontal tissue regeneration.
653 $aAsymmetric membrane
653 $aControlled release
653 $aElectrospinning
653 $aHierarchical materials
653 $aPeriodontal membrane
700 1 $aANNUNZIO, S. R. de
700 1 $aCARMELLO, J. C.
700 1 $aPAVARINA, A. C.
700 1 $aFONTANA, C. R.
700 1 $aCORREA, D. S.
773 $tACS Applied Bio Materials$gv. 5, 2022.
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