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| Registros recuperados : 25 | |
| 6. |  | TEODORO, R. L.; PEREIRA, J. C. C.; LEMOS, A. de M.; SAMPAIO, I. B. H.; FONSECA, C. G. da. Efeito de meio e heranca sobre o peso ao nascimento de bezerros da raca caracu. Arquivo da Escola de Veterinaria da UFMG, Belo Horizonte, v.31, n.3, p.463-470, 1970.| Biblioteca(s): Embrapa Gado de Leite. |
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| 7. | | MORAIS, O. R. de; BERGAMANN, J. A. G.; BENITEZ OJEDA, D.; FONSECA, C. G. da; BARBOSA, P. F. Efeito da herança citoplasmática sobre características de produção em ovinos da Raça Merino. Revista Brasileira de Zootecnia, Viçosa, MG, v.28, n.5, p.1007-1015, 1999.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 8. | | MORAIS, O. R. de; BERGMANN, J. A. G.; OJEDA, D. B.; FONSECA, C. G. da; PEDROSO, A. M. Efeito da herança citoplasmática sobre características de produção em ovinos da raça Merino. Revista Brasileira de Zootecnia, Viçosa, MG, v. 28, n. 5, p. 1007-1015, 1999.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 9. | | MORAIS, O. R. de; BERGMANN, J. A. G.; OJEDA, D. B.; FONSECA, C. G. da; BARBOSA, P. F. Efeito de linhagem citoplasmatica em caracteristicas de producao de ovinos da raca Merino. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 35., 1998, Botucatu, SP. Anais... Botucatu: Sociedade Brasileira de Zootecnia, 1998. v.3 p.306-308.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 14. | | FONSECA, P. A. S.; STEINBERG, R. S.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MACHADO, M. A.; FONSECA, C. G.; CARVALHO, M. R. S. Associação de polimorfismos nos genes da kappa-caseina e beta-lactoglubulina com produção e composição do leite na raça Guzerá. In: CONGRESSO BRASILEIRO DE GENÉTICA, 56., 2010, Guarujá. Resumos... Ribeirão Preto: Sociedade Brasileira de Genética, 2010.| Biblioteca(s): Embrapa Gado de Leite. |
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| 15. | | PEIXOTO, M. G. C. D.; FONSECA, C. G.; STEINBERG, R. S.; SOUSA, G. E.; VERNEQUE, R. S.; TEODORO, R. L.; MACHADO, M. A.; CARVALHO, M. R. S. Caracterização das variantes genéticas do gene DGAT1 na raça Guzerá (Bos indicus ) In: CONGRESSO INTERNACIONAL DO LEITE, 6., 2007, Resende. Anais... Juiz de Fora: Embrapa Gado de Leite, 2007. 1 CD.| Biblioteca(s): Embrapa Gado de Leite. |
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| 16. | | LACORTE, G. A.; MACHADO, M. A.; CAMPOS, A. L.; SILVA, R. S. da; CARVALHO, M. R. S.; FONSECA, C. G da. Caracterização do poliformismo DGAT1 VNTR em raças bovinas brasileiras. In: CONGRESSO BRASILEIRO DE GENÉTICA, 53., 2007, Águas de Lindóia. Resumos... Ribeirão Preto: SBG, 2007. p. 123.| Biblioteca(s): Embrapa Gado de Leite. |
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| 17. | | PEREIRA, L.; STEINBERG, R. S.; PEIXOTO, M. G. C. D.; MACHADO, M. A.; VERNEQUE, R. S.; TEODORO, R. L.; FONSECA, C. G.; CARVALHO, M. R. S. Detecção do polimorfismo K232A do gene DGAT1 através de tetra-primer ARMS-PCR. In: CONGRESSO BRASILEIRO DE GENÉTICA, 53., 2007, Águas de Lindóia. Resumos... Ribeirão Preto: SBG, 2007. p. 171.| Biblioteca(s): Embrapa Gado de Leite. |
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| 18. | | ASSIS, J. B. de; LAAT, D. M. de; PEIXOTO, M. G. C. D.; BERGMANN, J. A. G.; FONSECA, C. G.; CARVALHO, M. R. S. Genetic diversity and population structure in Brazilian Mangalarga Marchador horses. Genetics and Molecular Research, v. 8, n. 4, p. 1519-1524, 2009.| Biblioteca(s): Embrapa Gado de Leite. |
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| 20. | | STEINBERG, R. S.; PEREIRA, L.; LACORTE, G. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; TEODORO, R. L.; MACHADO, M. A.; FONSECA, C. G.; CARVALHO, M. R. S. Technical note: A new and cost-effective method for detection of the bovine acyl-CoA: diacyglycerol acyltransferase 1 K232A polymorphism in cattle. Journal of Dairy Science, v. 92, n. 2, p. 773-776, 2009.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 25 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
20/05/2014 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
ROSSE, I. da C.; STEINBERG, R. da S.; COIMBRA, R. S.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MACHADO, M. A.; FONSECA, C. G.; CARVALHO, M. R. S. |
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Afiliação: |
IZINARA DA CRUZ ROSSE, UFMG; RAPHAEL DA SILVA STEINBERG, UFMG; RONEY SANTOS COIMBRA, FIOCRUZ-Minas; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARCO ANTONIO MACHADO, CNPGL; CLEUSA GRAÇA FONSECA, UFMG; MARIA RAQUEL SANTOS CARVALHO, UFMG. |
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Título: |
Novel SNPs and INDEL polymorphisms in the 30UTR of DGAT1 gene: in silico analyses and a possible association. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Molecular Biological Reproduction, v. 41, n. 7, p. 4555-4563, 2014. |
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DOI: |
https://doi.org/10.1007/s11033-014-3326-z |
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Idioma: |
Inglês |
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Conteúdo: |
Diacylglycerol-O-acyltransferase (DGAT1) gene encodes the rate-limiting enzyme of triglyceride synthesis. A polymorphism in this gene, DGAT1 K232A, has been associated with milk production and composition in taurine breeds. However, this polymorphism is not a good tool for ascertaining the effects of this QTL in Bos indicus (Zebu), since the frequency of the DGAT1 232A allele is too low in these breeds. We sequenced the 3'-untranslated region of DGAT1 gene in a sample of bulls of the breeds Guzerá (Bos indicus) and Holstein (Bos taurus) and, using in silico analysis, we searched for genetic variation, evolutionary conservation, regulatory elements, and possible substitution effects. Six single nucleotide (SNPs) and one insertion-deletion (INDEL) polymorphisms were found in the Guzerá bulls. Additionally, we developed a preliminary association study, using this INDEL polymorphism as a genetic marker. A significant association was detected (P ≤ 0.05) between the INDEL (DGAT1 3'UTR INDEL) and the breeding values (BV) for protein, fat, and milk yields over a 305-day lactation period. The DGAT1 3' UTR INDEL genotype I/I (I, for insertion) was associated with lower BVs (-38.77 kg for milk, -1.86 kg for fat, and -1.48 kg for protein yields), when compared to the genotype I/D (D, for deletion). I/D genotype was lower D/D genotype (-34.98 kg milk, -1.73 kg fat, and -1.09 kg protein yields). This study reports the first polymorphism of DGAT1 3'UTR in the Guzerá breed, as well as its association with BV for milk protein, fat, and milk yields. MenosDiacylglycerol-O-acyltransferase (DGAT1) gene encodes the rate-limiting enzyme of triglyceride synthesis. A polymorphism in this gene, DGAT1 K232A, has been associated with milk production and composition in taurine breeds. However, this polymorphism is not a good tool for ascertaining the effects of this QTL in Bos indicus (Zebu), since the frequency of the DGAT1 232A allele is too low in these breeds. We sequenced the 3'-untranslated region of DGAT1 gene in a sample of bulls of the breeds Guzerá (Bos indicus) and Holstein (Bos taurus) and, using in silico analysis, we searched for genetic variation, evolutionary conservation, regulatory elements, and possible substitution effects. Six single nucleotide (SNPs) and one insertion-deletion (INDEL) polymorphisms were found in the Guzerá bulls. Additionally, we developed a preliminary association study, using this INDEL polymorphism as a genetic marker. A significant association was detected (P ≤ 0.05) between the INDEL (DGAT1 3'UTR INDEL) and the breeding values (BV) for protein, fat, and milk yields over a 305-day lactation period. The DGAT1 3' UTR INDEL genotype I/I (I, for insertion) was associated with lower BVs (-38.77 kg for milk, -1.86 kg for fat, and -1.48 kg for protein yields), when compared to the genotype I/D (D, for deletion). I/D genotype was lower D/D genotype (-34.98 kg milk, -1.73 kg fat, and -1.09 kg protein yields). This study reports the first polymorphism of DGAT1 3'UTR in the Guzerá breed, as well as its a... Mostrar Tudo |
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Palavras-Chave: |
3'Untranslated region; DGAT1; Genetic association study. |
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Thesagro: |
Bos Indicus. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02416naa a2200265 a 4500
001 1986563
005 2024-02-05
008 2014 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s11033-014-3326-z$2DOI
100 1 $aROSSE, I. da C.
245 $aNovel SNPs and INDEL polymorphisms in the 30UTR of DGAT1 gene$bin silico analyses and a possible association.$h[electronic resource]
260 $c2014
520 $aDiacylglycerol-O-acyltransferase (DGAT1) gene encodes the rate-limiting enzyme of triglyceride synthesis. A polymorphism in this gene, DGAT1 K232A, has been associated with milk production and composition in taurine breeds. However, this polymorphism is not a good tool for ascertaining the effects of this QTL in Bos indicus (Zebu), since the frequency of the DGAT1 232A allele is too low in these breeds. We sequenced the 3'-untranslated region of DGAT1 gene in a sample of bulls of the breeds Guzerá (Bos indicus) and Holstein (Bos taurus) and, using in silico analysis, we searched for genetic variation, evolutionary conservation, regulatory elements, and possible substitution effects. Six single nucleotide (SNPs) and one insertion-deletion (INDEL) polymorphisms were found in the Guzerá bulls. Additionally, we developed a preliminary association study, using this INDEL polymorphism as a genetic marker. A significant association was detected (P ≤ 0.05) between the INDEL (DGAT1 3'UTR INDEL) and the breeding values (BV) for protein, fat, and milk yields over a 305-day lactation period. The DGAT1 3' UTR INDEL genotype I/I (I, for insertion) was associated with lower BVs (-38.77 kg for milk, -1.86 kg for fat, and -1.48 kg for protein yields), when compared to the genotype I/D (D, for deletion). I/D genotype was lower D/D genotype (-34.98 kg milk, -1.73 kg fat, and -1.09 kg protein yields). This study reports the first polymorphism of DGAT1 3'UTR in the Guzerá breed, as well as its association with BV for milk protein, fat, and milk yields.
650 $aBos Indicus
653 $a3'Untranslated region
653 $aDGAT1
653 $aGenetic association study
700 1 $aSTEINBERG, R. da S.
700 1 $aCOIMBRA, R. S.
700 1 $aPEIXOTO, M. G. C. D.
700 1 $aVERNEQUE, R. da S.
700 1 $aMACHADO, M. A.
700 1 $aFONSECA, C. G.
700 1 $aCARVALHO, M. R. S.
773 $tMolecular Biological Reproduction$gv. 41, n. 7, p. 4555-4563, 2014.
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