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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
09/06/2016 |
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Data da última atualização: |
09/06/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BEARSON, B. L.; BEARSON, S. M. D.; KICH, J. D. |
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Afiliação: |
BRADLEY L. BEARSON, USDA/ARS; SHAWN MICHELLE DUNKIN BEARSON, USDA/ARS; JALUSA DEON KICH, CNPSA. |
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Título: |
A DIVA vaccine cross-protection against Salmonella. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Vaccine, v. 34, p. 1241-1246, 2016. |
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DOI: |
http://dx.doi.org/10.1016/j.vaccine.2016.01.036 |
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Idioma: |
Inglês |
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Conteúdo: |
Swine are often asymptomatic carriers of Salmonella spp., a leading cause of human bacterial foodborne disease. Vaccination against Salmonella is effective for protecting animal health and enhancing food safety. However, with >2500 Salmonella serovars, current vaccines for swine offer limited crossprotection against heterologous serovars. Also, existing vaccines can interfere with surveillance programs that monitor the Salmonella status of swine herds. To overcome Salmonella vaccine limitations, we rationally designed and constructed an attenuated Salmonella enterica serovar Typhimurium vaccine (BBS 866) by deleting multiple small regulatory RNA (sRNA) genes (omrA, omrB, rybB, micA, and invR) in combination with an rfaH mutation. We vaccinated swine intranasally at 3-weeks of age with PBS (mock-vaccinated), BBS 866 or BBS 202 (S. Typhimurium rfaH, Bearson et al., Front Vet Sci 2014;1:9.) and challenged at 7-weeks of age with virulent S. Choleraesuis, a swine pathogen. Vaccination with BBS 866 enhanced protection against S. Choleraesuis by significantly limiting the duration of fever, weight loss, the levels of circulating INF, and the total number of swine with S. Choleraesuis septicemia. Vaccination with either BBS 866 or BBS 202 significantly reduced S. Choleraesuis colonization of both systemic (spleen and liver) and gastrointestinal (Peyer’s Patch, Ileocecal lymph nodes, and cecum) tissues. Similar to our earlier report for BBS 202, the BBS 866 vaccine strain can be used in swine without compromising the differentiation of infected from vaccinated animals (DIVA). Therefore, the attenuated S. Typhimurium BBS 866 strain, containing mutations in rfaH and multiple sRNAs, addresses the limitations of current Salmonella vaccines by providing cross-protection against Salmonella serovars in swine without interfering with established monitoring programs for Salmonella surveillance. MenosSwine are often asymptomatic carriers of Salmonella spp., a leading cause of human bacterial foodborne disease. Vaccination against Salmonella is effective for protecting animal health and enhancing food safety. However, with >2500 Salmonella serovars, current vaccines for swine offer limited crossprotection against heterologous serovars. Also, existing vaccines can interfere with surveillance programs that monitor the Salmonella status of swine herds. To overcome Salmonella vaccine limitations, we rationally designed and constructed an attenuated Salmonella enterica serovar Typhimurium vaccine (BBS 866) by deleting multiple small regulatory RNA (sRNA) genes (omrA, omrB, rybB, micA, and invR) in combination with an rfaH mutation. We vaccinated swine intranasally at 3-weeks of age with PBS (mock-vaccinated), BBS 866 or BBS 202 (S. Typhimurium rfaH, Bearson et al., Front Vet Sci 2014;1:9.) and challenged at 7-weeks of age with virulent S. Choleraesuis, a swine pathogen. Vaccination with BBS 866 enhanced protection against S. Choleraesuis by significantly limiting the duration of fever, weight loss, the levels of circulating INF, and the total number of swine with S. Choleraesuis septicemia. Vaccination with either BBS 866 or BBS 202 significantly reduced S. Choleraesuis colonization of both systemic (spleen and liver) and gastrointestinal (Peyer’s Patch, Ileocecal lymph nodes, and cecum) tissues. Similar to our earlier report for BBS 202, the BBS 866 vaccine strain can be used... Mostrar Tudo |
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Palavras-Chave: |
Salmonela; Vaccine. |
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Thesagro: |
Imunidade; Salmonella; Suíno; Vacina. |
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Thesaurus Nal: |
Cross immunity; Swine. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02580naa a2200253 a 4500
001 2046719
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008 2016 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.1016/j.vaccine.2016.01.036$2DOI
100 1 $aBEARSON, B. L.
245 $aA DIVA vaccine cross-protection against Salmonella.$h[electronic resource]
260 $c2016
520 $aSwine are often asymptomatic carriers of Salmonella spp., a leading cause of human bacterial foodborne disease. Vaccination against Salmonella is effective for protecting animal health and enhancing food safety. However, with >2500 Salmonella serovars, current vaccines for swine offer limited crossprotection against heterologous serovars. Also, existing vaccines can interfere with surveillance programs that monitor the Salmonella status of swine herds. To overcome Salmonella vaccine limitations, we rationally designed and constructed an attenuated Salmonella enterica serovar Typhimurium vaccine (BBS 866) by deleting multiple small regulatory RNA (sRNA) genes (omrA, omrB, rybB, micA, and invR) in combination with an rfaH mutation. We vaccinated swine intranasally at 3-weeks of age with PBS (mock-vaccinated), BBS 866 or BBS 202 (S. Typhimurium rfaH, Bearson et al., Front Vet Sci 2014;1:9.) and challenged at 7-weeks of age with virulent S. Choleraesuis, a swine pathogen. Vaccination with BBS 866 enhanced protection against S. Choleraesuis by significantly limiting the duration of fever, weight loss, the levels of circulating INF, and the total number of swine with S. Choleraesuis septicemia. Vaccination with either BBS 866 or BBS 202 significantly reduced S. Choleraesuis colonization of both systemic (spleen and liver) and gastrointestinal (Peyer’s Patch, Ileocecal lymph nodes, and cecum) tissues. Similar to our earlier report for BBS 202, the BBS 866 vaccine strain can be used in swine without compromising the differentiation of infected from vaccinated animals (DIVA). Therefore, the attenuated S. Typhimurium BBS 866 strain, containing mutations in rfaH and multiple sRNAs, addresses the limitations of current Salmonella vaccines by providing cross-protection against Salmonella serovars in swine without interfering with established monitoring programs for Salmonella surveillance.
650 $aCross immunity
650 $aSwine
650 $aImunidade
650 $aSalmonella
650 $aSuíno
650 $aVacina
653 $aSalmonela
653 $aVaccine
700 1 $aBEARSON, S. M. D.
700 1 $aKICH, J. D.
773 $tVaccine$gv. 34, p. 1241-1246, 2016.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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| Registros recuperados : 15 | |
| 7. |  | SOARES, J. P. G.; AROEIRA, L. J. M.; FONSECA, A. H. DA; SANAVRIA, A.; SILVA, J. B.; FAGUNDES, G. M. Produção orgânica de leite no Brasil: tecnologias para produção sustentável. In: Congresso Brasileiro de Raças Zebuínas, 8., / Simpósio Pecuária Tropical Sustentável, 2011, Uberaba. Anais...| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 9. | | SOCOLOSKI, S. N. G.; CASTRO, B. G. de; CORDEIRO, M. D.; FONSECA, A. H. da; CEPEDA, M. B.; NICOLINO, R. R.; LOPES, L. B. Epidemiological investigation of Borrelia burgdorferi in horses in the municipality of Sinop-MT, Brazil. Tropical Animal Health and Production, v. 50, n. 4, p. 831-836, 2018. 6 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Agrossilvipastoril. |
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| 10. | | SALGADO, F. P.; HONER, M. R.; ISHIKAWA, M. M.; MADUREIRA, R. C.; SOARES, C. O.; RIGO, L.; FONSECA, A. H. da. Detecção de anticorpos Ant-Borrelia burgdorferi em cães procedenes do Centro de Controle de Zoonoses de Campo Grande, Mato Grosso do Sul, Brasil. Revista Brasileira de Medicina Veterinária, v. 30, n. 2, p. 97-101, abr./jun. 2008.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Nacional - B |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 11. | | SALGADO, F. P.; HONER, M. R.; ISHIKAWA, M. M.; MADUREIRA, R. C.; SOARES, C. O.; RIGO, L.; FONSECA, A. H. da. Detecção de anticorpos anti-Borrelia burgdorferi em cães procedentes do Centro de Controle de Zoonoses de Campo Grande, Mato Grosso do Sul, Brasil. Revista Brasileira de Medicina Veterinária, Rio de Janeiro, v. 30, n. 2, p. 97- 101, abr./jun. 2008.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Nacional - B |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 12. | | BONADIMANN, S. N. G. S.; CORDEIRO, M. D.; BAUTISTA, J. L. R.; SILVA, J. B. da; NICOLINO, R. R.; FONSECA, A. H. da; LOPES, L. B. Serological and molecular detection of Theileria equi in horses from Sinop, Mato Grosso state, Brazil. Revista Brasileira de Ciência Veterinária, v. 28, n. 3, p. 156-161, 2021. Título em português: Detecção sorológica e molecular de Theileria equi em equinos oriundos de Sinop, Mato Grosso, Brasil.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Agrossilvipastoril. |
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| 13. | | CAMPOS, S. D. E.; CUNHA, N. C. da; MACHADO, C. S. C.; SOUZA, T. V. T. de; FONSECA, A. B. M.; PINTER, A.; FONSECA, A. H. da; ALMOSNY, N. R. P. Circulação de Rickettsias do Grupo da Febre Maculosa em cães no entorno de Unidades de Conservação Federais do estado do Rio de Janeiro: evidência sorológica e fatores associados. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 11, p. 1307-1312, novembro 2017. Título em inglês: Spotted Fever Group Rickettsiae in dogs at the surroundings of Conservation Units in the state of Rio de Janeiro: serological survey and associated factors.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 14. | | SILVA, J. B. da; LOPES, C. T. de A.; SOUZA, M. G. S. de; GIBSON, A. F. B.; VINHOTE, W. M. de S.; FONSECA, A. H. da; ARAUJO, F. R.; BARBOSA-NETO, J. D. Detecção sorológica e molecular de Anaplasma marginale em búfalos na Ilha de Marajó, Pará. Pesquisa Veterinária Brasileira, v. 34, n. 1, p. 11-14, jan., 2014| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 15. | | TEMBUE, A. A. M.; SILVA, J. B. da; SILVA, F. J. M. da; PIRES, M. S.; BADANI, C. D.; SOARES, C. O.; MASSARD, C. L.; FONSECA, A. H. da. Seroprevalence of IgG antibodies against Anaplasma marginale in cattle from south Mozambique. Revista Brasileira de Parasitologia Veterinária, v. 20, n. 4, p. 318-324, out-dez. 2011. 20| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| Registros recuperados : 15 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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