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| Registros recuperados : 78 | |
| 42. |  | OLIVEIRA JUNIOR, G. A.; VENTURA, R.; FREITAS, B. G. de; SANTANA, M. H. A.; SILVA, M. V. G. B.; FERRAZ, J. B. S.; GARRICK, D. J. Genome-wide association study in reproductive trait of Nellore heifers. In: PLANT & ANIMAL GENOME, 24., 2016, San Diego. [Proceedings...] San Diego: [s.n.], 2016.| Biblioteca(s): Embrapa Gado de Leite. |
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| 43. | | SANTANA JUNIOR, M. L.; ELER, J. P.; CARDOSO, F. F.; ALBUQUERQUE, L. G.; BALIEIRO, J. C. C.; PEREIRA, R. J.; FERRAZ, J. B. S. Genotype by environment interaction for post-weaning weight gain, scrotal circumference, and muscling score of composite beef cattle in different regions of Brazil. Genetics and Molecular Research, Ribeirão Preto, v. 13, n. 2, p. 3048-3059, 2014.| Biblioteca(s): Embrapa Pecuária Sul. |
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| 44. | | FELÍCIO, A. M.; BOSCHIERO, C.; BALIEIRO, J. C. C.; LEDUR, M. C.; FERRAZ J. B. S.; MICHELAN FILHO, T.; MOURA, A. S. A. M. T.; COUTINHO, L. L. Identification and association of polymorphisms in CAPN1 and CAP3 candidate genes related to performance and meat quality traits in chickens. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 1, p. 472-482, 2013.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 45. | | PANETTO, J. C. C.; VAL, J. E.; MARCONDES, C. R.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; FERRAZ, J. B. S.; GOLDEN, B. L. Female fertility in a Guzerat dairy subpopulation: heterogeneity of variance components for calving intervals. Livestock Science, v. 145, n. 1-3, p. 87-94, may 2012.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 46. | | OLIVEIRA, P. S.; SANTANA JÚNIOR, M. L.; PEDROSA, V. B.; OLIVEIRA, E. C. de M.; ELER, J. P.; FERRAZ, J. B. S. Estrutura populacional de rebanho fechado da raça Nelore da linhagem Lemgruber. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 46, n. 6, p. 639-647, jun. 2011 Título em inglês: Population structure of a closed herd of Nellore cattle of the Lemgruber line.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 47. | | FIGUEIREDO, C. L.; BALIEIRO, J. C. de C.; MATTOS, E. C. de; BALIEIRO, C. de C.; ELER, J. P.; FERRAZ, J. B. S. Estimativas de parâmetros genéticos para fertilidade ao parto e número de cordeiros nascidos ao parto em ovinos da raça Santa Inês. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 44., 2007, Jaboticabal. O avanço científico e tecnológico na produção animal: anais. Jaboticabal: Sociedade Brasileira de Zootecnia: UNESP, Faculdade de Ciências Agrárias e Veterinárias, 2007. 3 f. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 48. | | COSTA, K. C. P. da; FERRAZ, J. B. S.; BASTOS, R. P.; REIS, T. da S.; FERREIRA, M. J.; GUIMARÃES, G. P. Estoques de biomassa e nutrientes em três espécies de Parkia em plantios jovens sobre área degradada na Amazônia Central. Floresta, Curitiba, v. 44, n. 4, p. 637-646, 2014.| Biblioteca(s): Embrapa Florestas. |
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| 49. | | OLIVEIRA JUNIOR, G. A.; REY, F. S. B.; SILVA, M. V. G. B.; SANTANA, M. H. A.; ALEXANDRE, P. A.; ELER, J. P.; FERRAZ, J. B. S. Analysis of copy number variation regions in a Nellore population evaluated for feed efficiency. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver. Proceedings... Champaign: ASAS, 2014. 3 p.| Biblioteca(s): Embrapa Gado de Leite. |
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| 50. | | CARVALHO, M. E.; ELER, J. P.; AFAZ, A. L. M.; FERRAZ, J. B. S.; REGITANO, L. C. de A.; MEIRELLES, F. V.; BALIEIRO, J. C. de C. A. Avaliação de diferentes combinações genotípicas para polimorfismo no gene u-calpaína e calpastatina associados com a maciez da carne em bovinos da raça Nelore. In: CONGRESSO BRASILEIRO DE CIÊNCIA E TECNOLOGIA DE CARNES, 4., 2007, Campinas, SP. Mercado do Século XXI: qualidade, segurança alimentar, certificação e rastreabilidade - Anais... Campinas: ITAL: CTC, 2007. p. 253-255. 1 CD-ROM.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 51. | | OLIVEIRA JUNIOR, G. A.; CARMO, A. S.; UTSUNOMIYA, A. T. H.; CHUD, T. C. S.; REY, F. S. B.; FERRAZ, J. B. S.; SILVA, M. V. G. B. Common copy number variation regions affecting dairy traits in Gyr cattle In: ADSA ASAS JOINT ANNUAL MEETING, 2015, Orlando. Proceedings... Orlando: ADSA: ASAS, 2015.| Biblioteca(s): Embrapa Gado de Leite. |
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| 52. | | SILVA, M. V. G. B.; OLIVEIRA JUNIOR, G.; REY, F. S. B.; GIACHETTO, P. F.; MACHADO, M. A.; VERNEQUE, R. da S.; FERRAZ, J. B. S. Descriptive analysis of copy number variation regions in a population of dairy Gyr cattle. In: WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver. Proceedings... Champaign: American Society of Animal Science, 2014. 3 p.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Gado de Leite. |
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| 53. | | SALVIAN, M.; RAMÍREZ-DÍAZ, J.; CUCCO, D. C.; SANTANA, M. H.; BONIN, M. N.; GOMES, R. da C.; FERRAZ, J. B. S.; MOURÃO, G. B. Multivariate analyses of live-animal ultrasound carcass traits of composite cattle. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. The integration of Knowledge in animal production - abstracts. Campinas: SBZ, 2013 1 CD ROM| Biblioteca(s): Embrapa Gado de Corte. |
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| 54. | | GOMES, R. da C.; SILVA, S. L.; SANTANA, M. H. A.; FERRAZ, J. B. S.; ROSSI JR, P.; LEME, P. R. Phenotypic correlations of the residual intake and gain with ultrasound carcass traits and other feed efficiency measures in Nellore cattle. Journal of Animal Science v.90, (Supplement 3/J); Journal of Dairy Science, v.95, (Supplement 2), p.515, 2012. Edição dos trabalhos do: ADSA-PSA-AMPA-ASAS-CSAS-WSASAS JOINT ANNUAL MEETING, 2012, Phoenix-AR. Beef Species. W41.| Biblioteca(s): Embrapa Gado de Corte. |
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| 55. | | FELÍCIO, A. M.; BOSCHIERO, C.; BALIEIRO, J. C. C.; LEDUR, M. C.; FERRAZ J. B. S.; MOURA, A. S. A. M. T.; COUTINHO, L. L. Polymorphisms in FGFBP1 and FGFBP2 genes associated with carcass and meat quality traits in chickens. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 1, p. 208-222, 2013.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 56. | | MORAES, J. C. F.; SOUZA, C. J. H. de; BRAUNER, C. C.; PIMENTEL, M. A.; BENAVIDES, M. V.; FERRAZ, J. B. S. Utilização do escore de condição corporal pós-parto na identificação de vacas de corte mais férteis criadas em sistemas extensivos. Archivos Latinoamericanos de Producción Animal, Maracaibo, v. 21, n. 3, p. 149-155, 2013.| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura. |
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| 57. | | LOBO, A. M. B. O.; LOBO, R. N. B.; FACO, O.; FONSECA, J. F. da; PAIVA, S. R.; SILVA, M. V. G. B.; CAETANO, A. R.; FERRAZ, J. B. S.; BIAZIO, G. R. de. Programa de Melhoramento Genético de Caprinos Leiteiros Capragene®, 1º sumário de avaliação genética genômica, 2º sumário de avaliação genética, raça Saanen - Ano 2017. 2. ed. rev. ampl. Brasília, DF: Embrapa, 2017. 51 p.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 58. | | LOBO, A. M. B. O.; LOBO, R. N. B.; FACO, O.; FONSECA, J. F. da; PAIVA, S. R.; SILVA, M. V. G. B.; CAETANO, A. R.; FERRAZ, J. B. S.; BIAZIO, G. R. de. Programa de Melhoramento Genético de Caprinos Leiteiros Capragene®, 2º sumário de avaliação genética, 1º sumário de avaliação genética genômica raça Saanen - Ano 2017. Sobral: Embrapa Caprinos e Ovinos, 2017. 39 p.| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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| 59. | | GOMES, R. da C.; SILVA, S. L.; CARVALHO, M. E.; REZENDE, F. M.; PINTO, L. F. B.; SANTANA, M. H. A.; STELLA, T. R.; MEIRELLES, F. V.; ROSSI JÚNIOR, P.; LEME, P. R.; FERRAZ, J. B. S. Protein synthesis and degradation gene SNPs related to feed intake, feed efficiency, growth, and ultrasound carcass traits in Nellore cattle. Genetics and Molecular Research, v. 12, n. 3, p. 2923-2936, 2013.| Biblioteca(s): Embrapa Gado de Corte. |
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| 60. | | OLIVEIRA JÚNIOR, G. A.; CHUD, T. C. S.; VENTURA, R. V.; GARRICK, D. J.; COLE, J. B.; MUNARI, D. P.; FERRAZ, J. B. S.; MULLART, E.; DeNISE, S.; SMITH, S.; SILVA, M. V. G. B. Genotype imputation in a tropical crossbred dairy cattle population. Journal of Dairy Science, v. 100, n. 12, p. 9623-9634, 2017.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 78 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
03/03/2017 |
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Data da última atualização: |
03/03/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 1 |
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Autoria: |
SANTANA, M. H. de A.; OLIVEIRA JUNIOR, G. A.; CESAR, A. S. M.; FREUA, M. C.; GOMES, R. da C.; SILVA, S. da L.; LEME, P. R.; FUKUMASU, H.; CARVALHO, M. E.; VENTURA, R. V.; COUTINHO, L. L.; KADARMIDEEN, H. N.; FERRAZ, J. B. S. |
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Afiliação: |
MIGUEL HENRIQUE DE ALMEIDA SANTANA; GERSON ANTÔNIO OLIVEIRA JUNIOR; ALINE SILVA MELLO CESAR; MATEUS CASTELANI FREUA; RODRIGO DA COSTA GOMES, CNPGC; SAULO DA LUZ E SILVA; PAULO ROBERTO LEME; HEIDGE FUKUMASU; MINOS ESPERÂNDIO CARVALHO; RICARDO VIEIRA VENTURA; LUIZ LEHMANN COUTINHO; HAJA N. KADARMIDEEN; JOSÉ BENTO STERMAN FERRAZ. |
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Título: |
Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Journal of Applied Gentics, v. 57, n. 4, p. 495-504, 2016 |
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Idioma: |
Inglês |
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Conteúdo: |
The use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid, and protein metabolism. The metabolic pathways found in this study are related to processes directly connected to feed efficiency in beef cattle. It was observed that, even though different genomic regions and genes were found between the two approaches (GWAS and CNV), the metabolic processes covered were related to each other. Therefore, a combination of the approaches complement each other and lead to a better understanding of the FCR. MenosThe use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid,... Mostrar Tudo |
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Palavras-Chave: |
GWAS; Nellore cattle. |
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Thesaurus NAL: |
Cattle; Cucumber necrosis virus; Feed conversion; Genomics; Single nucleotide polymorphism. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/157039/1/Copy-number-variations-and-genome-wide.pdf
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Marc: |
LEADER 03009naa a2200349 a 4500
001 2066092
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008 2016 bl uuuu u00u1 u #d
100 1 $aSANTANA, M. H. de A.
245 $aCopy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle.$h[electronic resource]
260 $c2016
520 $aThe use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid, and protein metabolism. The metabolic pathways found in this study are related to processes directly connected to feed efficiency in beef cattle. It was observed that, even though different genomic regions and genes were found between the two approaches (GWAS and CNV), the metabolic processes covered were related to each other. Therefore, a combination of the approaches complement each other and lead to a better understanding of the FCR.
650 $aCattle
650 $aCucumber necrosis virus
650 $aFeed conversion
650 $aGenomics
650 $aSingle nucleotide polymorphism
653 $aGWAS
653 $aNellore cattle
700 1 $aOLIVEIRA JUNIOR, G. A.
700 1 $aCESAR, A. S. M.
700 1 $aFREUA, M. C.
700 1 $aGOMES, R. da C.
700 1 $aSILVA, S. da L.
700 1 $aLEME, P. R.
700 1 $aFUKUMASU, H.
700 1 $aCARVALHO, M. E.
700 1 $aVENTURA, R. V.
700 1 $aCOUTINHO, L. L.
700 1 $aKADARMIDEEN, H. N.
700 1 $aFERRAZ, J. B. S.
773 $tJournal of Applied Gentics$gv. 57, n. 4, p. 495-504, 2016
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