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Registro Completo |
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Biblioteca(s): |
Embrapa Mandioca e Fruticultura. |
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Data corrente: |
11/01/2001 |
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Data da última atualização: |
11/01/2001 |
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Autoria: |
MARTIN, C. K. A. |
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Afiliação: |
Gesellschfat fur Biotechnologische Forschung mbH, Braunschweig-Stockeim, West Germany. |
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Título: |
Microbial cleavage of sterol side chains |
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Ano de publicação: |
1975 |
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Fonte/Imprenta: |
S.n.t., p.29-54, [1975]. |
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Idioma: |
Inglês |
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Conteúdo: |
The recent interest in the microbial conversion of sterol to C19 steroids was caused by the incresead demand for steroid drugs and the increased demand for steroid drugs and the shortage of diosgenin. Based upon studies on the pathway of sterol metabolism by certain bacteria methods for the selective cleavage of the 17-alkyl side chain of cholesterol and phytosterols were developed on a laboratory scale. These methods consist in the inhibition of the enzymas responsible for the primary attack of the steroid ring system. Structural modification of the substrates, fermentation in the presence of enzyme inhibitors, or mutagenic treatment were employed to achieve this goal. Since the microbial process has to compete witch chemical methods, higs, high conversion efficiencies in the presence of large substrate concetrations have to be obtained. Some of these process are used now an industrial scale for the production of 17-ketosteroids. |
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Palavras-Chave: |
Bacterial methods; Chemical methods; Metodos bacterianos; Metodos quimicos; Steroid. |
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Thesagro: |
Biotecnologia; Esteróide. |
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Thesaurus Nal: |
biotechnology. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01484naa a2200217 a 4500
001 1649822
005 2001-01-11
008 1975 bl --- 0-- u #d
100 1 $aMARTIN, C. K. A.
245 $aMicrobial cleavage of sterol side chains
260 $c1975
520 $aThe recent interest in the microbial conversion of sterol to C19 steroids was caused by the incresead demand for steroid drugs and the increased demand for steroid drugs and the shortage of diosgenin. Based upon studies on the pathway of sterol metabolism by certain bacteria methods for the selective cleavage of the 17-alkyl side chain of cholesterol and phytosterols were developed on a laboratory scale. These methods consist in the inhibition of the enzymas responsible for the primary attack of the steroid ring system. Structural modification of the substrates, fermentation in the presence of enzyme inhibitors, or mutagenic treatment were employed to achieve this goal. Since the microbial process has to compete witch chemical methods, higs, high conversion efficiencies in the presence of large substrate concetrations have to be obtained. Some of these process are used now an industrial scale for the production of 17-ketosteroids.
650 $abiotechnology
650 $aBiotecnologia
650 $aEsteróide
653 $aBacterial methods
653 $aChemical methods
653 $aMetodos bacterianos
653 $aMetodos quimicos
653 $aSteroid
773 $tS.n.t., p.29-54, [1975].
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Registro original: |
Embrapa Mandioca e Fruticultura (CNPMF) |
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