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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
03/11/2023 |
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Data da última atualização: |
03/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
COSTA, V. P. V. da; SANTOS, D. M. dos; ANDRE, R. S.; LOPES, R. G.; INADA, N. M.; CORREA, D. S. |
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Afiliação: |
Nanotechnology National Laboratory for Agriculture (LNNA); Nanotechnology National Laboratory for Agriculture (LNNA); Nanotechnology National Laboratory for Agriculture (LNNA); University of Sao Paulo (USP); University of Sao Paulo (USP); DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Bilayer nonwovens using natural rubber, poly(lactic acid) and bactericidal nanoparticles for wound dressings. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Materials Today Communications, v. 37, 107260, 2023. |
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Páginas: |
13 p. |
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ISSN: |
2352-4928 |
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DOI: |
https://doi.org/10.1016/j.mtcomm.2023.107260 |
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Idioma: |
Inglês |
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Conteúdo: |
ABSTRACT Wound healing poses a significant challenge in healthcare, impacting not only on patients? quality of life but also placing a substantial financial burden on healthcare systems. Bilayer nonwovens have emerged as a promising solution for wound dressings due to their porous morphology, providing a high surface area for cellular adhesion and growth, and their permeability, allowing proper oxygen and fluid exchange to promote wound healing. When bactericide materials are added to the formulation, they can decrease or prevent infection caused by microorganisms, further aiding the healing process. Solution blow spinning is an appealing technique for creating bilayer nonwovens as it can produce high yields at a low cost. Yet, even though natural rubber boasts a well-established safety record in biomaterials, it remains an underexplored candidate for generating micronanofibrous structures. In this study, solution blow spinning was employed to fabricate bilayer composite nonwovens for wound dressing materials. The material architecture consisted of a bottom layer composed of a blend of natural rubber, poly(lactic acid) (PLA), and polyethylene glycol in the respective proportion of 2:1:3 w/ w and a top layer composed of PLA and ZnO nanoparticles added in concentrations of 1%, 2.5%, and 5% based on the PLA mass of this layer. The top layer was further functionalized with Ag nanoparticles through spraying. The obtained materials demonstrated satisfactory hydrophobicity for cellular adhesion in the bottom layer, ranging from 51.95◦ to 92.20◦ of water sessile drop contact angle, and tunable mechanical strength, which could be controlled by varying the content of ZnO nanoparticles. Additionally, the material showed antimicrobial properties due to the presence of added Ag nanoparticles, able to inhibit E. coli, S. enterica serovar Typhimurium, and S. aureus by direct contact. Besides, the nonwoven prevented the passage of microorganisms due to the pore size of the structure. Overall, the unique properties of the developed material, such as its low cost, ease of production, and remarkable wound-healing properties, make it a promising candidate for wound dressing applications. MenosABSTRACT Wound healing poses a significant challenge in healthcare, impacting not only on patients? quality of life but also placing a substantial financial burden on healthcare systems. Bilayer nonwovens have emerged as a promising solution for wound dressings due to their porous morphology, providing a high surface area for cellular adhesion and growth, and their permeability, allowing proper oxygen and fluid exchange to promote wound healing. When bactericide materials are added to the formulation, they can decrease or prevent infection caused by microorganisms, further aiding the healing process. Solution blow spinning is an appealing technique for creating bilayer nonwovens as it can produce high yields at a low cost. Yet, even though natural rubber boasts a well-established safety record in biomaterials, it remains an underexplored candidate for generating micronanofibrous structures. In this study, solution blow spinning was employed to fabricate bilayer composite nonwovens for wound dressing materials. The material architecture consisted of a bottom layer composed of a blend of natural rubber, poly(lactic acid) (PLA), and polyethylene glycol in the respective proportion of 2:1:3 w/ w and a top layer composed of PLA and ZnO nanoparticles added in concentrations of 1%, 2.5%, and 5% based on the PLA mass of this layer. The top layer was further functionalized with Ag nanoparticles through spraying. The obtained materials demonstrated satisfactory hydrophobicity for cell... Mostrar Tudo |
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Palavras-Chave: |
Asymmetric membrane; Natural polymers; Natural rubber; Skin infection. |
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Categoria do assunto: |
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Marc: |
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001 2157764
005 2023-11-03
008 2023 bl uuuu u00u1 u #d
022 $a2352-4928
024 7 $ahttps://doi.org/10.1016/j.mtcomm.2023.107260$2DOI
100 1 $aCOSTA, V. P. V. da
245 $aBilayer nonwovens using natural rubber, poly(lactic acid) and bactericidal nanoparticles for wound dressings.$h[electronic resource]
260 $c2023
300 $a13 p.
520 $aABSTRACT Wound healing poses a significant challenge in healthcare, impacting not only on patients? quality of life but also placing a substantial financial burden on healthcare systems. Bilayer nonwovens have emerged as a promising solution for wound dressings due to their porous morphology, providing a high surface area for cellular adhesion and growth, and their permeability, allowing proper oxygen and fluid exchange to promote wound healing. When bactericide materials are added to the formulation, they can decrease or prevent infection caused by microorganisms, further aiding the healing process. Solution blow spinning is an appealing technique for creating bilayer nonwovens as it can produce high yields at a low cost. Yet, even though natural rubber boasts a well-established safety record in biomaterials, it remains an underexplored candidate for generating micronanofibrous structures. In this study, solution blow spinning was employed to fabricate bilayer composite nonwovens for wound dressing materials. The material architecture consisted of a bottom layer composed of a blend of natural rubber, poly(lactic acid) (PLA), and polyethylene glycol in the respective proportion of 2:1:3 w/ w and a top layer composed of PLA and ZnO nanoparticles added in concentrations of 1%, 2.5%, and 5% based on the PLA mass of this layer. The top layer was further functionalized with Ag nanoparticles through spraying. The obtained materials demonstrated satisfactory hydrophobicity for cellular adhesion in the bottom layer, ranging from 51.95◦ to 92.20◦ of water sessile drop contact angle, and tunable mechanical strength, which could be controlled by varying the content of ZnO nanoparticles. Additionally, the material showed antimicrobial properties due to the presence of added Ag nanoparticles, able to inhibit E. coli, S. enterica serovar Typhimurium, and S. aureus by direct contact. Besides, the nonwoven prevented the passage of microorganisms due to the pore size of the structure. Overall, the unique properties of the developed material, such as its low cost, ease of production, and remarkable wound-healing properties, make it a promising candidate for wound dressing applications.
653 $aAsymmetric membrane
653 $aNatural polymers
653 $aNatural rubber
653 $aSkin infection
700 1 $aSANTOS, D. M. dos
700 1 $aANDRE, R. S.
700 1 $aLOPES, R. G.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
773 $tMaterials Today Communications$gv. 37, 107260, 2023.
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| 3. |  | FEISTAUER, D.; OURIQUES, M.; MONTOYA VILCAHUAMAN, L. J.; VIEIRA, A. R. R.; SOARES, A. Seqüestro de carbono de um sistema agroflorestal com bracatinga (Mimosa scabrella Bentham) na região metropolitana de Curitiba - PR. In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p.175-177. (Embrapa Florestas. Documentos, 98).| Biblioteca(s): Embrapa Florestas. |
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| 5. | | MARTINS, C. E. N.; FEISTAUER, D.; VIEIRA, A. R. R.; PORFÍRIO-DA-SILVA, V.; QUADROS, S. F. A. de. Crescimento de espécies nativas e produção de material formador da serapilheira em um sistema silvipastoril. In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 470-472. (Embrapa Florestas. Documentos, 98).| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Florestas. |
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| 6. | | MARTINS, C. E. N.; VIEIRA, A. R. R.; PORFÍRIO-DA-SILVA, V.; VINCENZI, M. L.; QUADROS, S. A. F. de; FEISTAUER, D.; APA, H. C. G. do R.; OURIQUES, M.; PROBST, R.; PATRÍCIO, L. A. Avaliação da composição botânica de um campo nativo melhorado em um sistema silvipastoril. Revista Brasileira Agroecologia, v. 2, n. 1, p. 1641-1644, 2007. Edição dos Resumos do II Congresso Brasileiro de Agroecologia, Guarapari, 2007.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Florestas. |
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| 7. | | MARTINS, C. E. N.; VIEIRA, A. R. R.; PORFÍRIO-DA-SILVA, V.; VINCENZI, M. L.; QUADROS, S. A. F. de; FEISTAUER, D.; RIO APA, H. C. G. do; OURIQUES, M.; PROBST, R.; PATRÍCIO, L. A. Avaliação de espécies arbóreas em um sistema silvipastoril no município de Imaruí, SC. Revista Brasileira Agroecologia, v. 2, n. 1, p. 1637-1640, 2007. Edição dos Resumos do II Congresso Brasileiro de Agroecologia, Guarapari, 2007.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 7 | |
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