| |
|
|
| Registros recuperados : 57 | |
| 41. |  | GUEDES, M. D. V.; MARQUES, M. S.; BERLITZ, S. J.; FACURE, M. H. M.; CORREA, D. S.; STEFFENS, C.; CONTRI, R. V.; KÜLKAMP-GUERRREIRO, I. C. Lamivudine and Zidovudine-Loaded Nanostructures: Green Chemistry Preparation for Pediatric Oral Administration. Nanomaterials, v. 13, 770, 2023. 1 - 18| Biblioteca(s): Embrapa Instrumentação. |
|    |
| 42. | | PAULA, K. T.; SANTOS, M. V.; FACURE, M. H. M.; ANDRADE, M. B.; ARAÚJO, F. L.; CORREA, D. S.; RIBEIRO, S. J. L.; MENDONÇA, K. R. Laser patterning and induced reduction of graphene oxide functionalized silk fibroin. Optical Materials, n. 99, a. 109540, 2020. 1 - 6| Biblioteca(s): Embrapa Instrumentação. |
| |
| 43. | | FUKUSHIMA, K. L.; SCAGION, V. P.; FACURE, M. H. M.; PINHEIRO, A. C. M.; CORREA, D. S.; NUMES, C. A.; OLIVEIRA, J. E. Development of an electronic tongue based on a nanocomposite for discriminating flavor enhancers and commercial salts. IEEE Sensors Journal, v. 21, n. 2, 2021. 1250-1256| Biblioteca(s): Embrapa Instrumentação. |
| |
| 44. | | MERCANTE, L. A.; SCHNEIDER, R.; FACURE, M. H. M.; ANDRE. R. S.; TEODORO, K.; MARTINS, D.; MIGLIORINI, F.; CORREA, D. S. ELETROFIAÇÃO: PARÂMETRO E CONFIGURAÇÕES DE SISTEMA, TIPOS DE FIBRAS E MÉTODOS DE MODIFICAÇÃO. In: MERCANTE, L. A.; CORRÊA, D. S. (org.). Eletrofiação e nanofibras: fundamentos e aplicações. Ponta Grossa, PR: Atena Editora, 2023. cap. 2. 13-51| Biblioteca(s): Embrapa Instrumentação. |
|  |
| 45. | | PAULA, K. T.; GAÁL, G.; ALMEIDA, G. F. B.; ANDRADE, M. B.; FACURE, M. H. M.; CORREA, D. S.; RIUL JUNIOR, A.; RODRIGUES, V.; MENDONÇA, C. R. Femtosecond laser micromachining of polylactic acid/graphene composites for designing interdigitated microelectrodes for sensor applications. Optics and Laser Technology, v. 101, p. 74-79, 2018.| Biblioteca(s): Embrapa Instrumentação. |
| |
| 46. | | PAULA, K. T.; SANTOS, S. N. C.; FACURE, M. H. M.; ARAUJO, F. L.; ANDRADE, M. B.; CORREA, D. S.; MENDONÇA, C. R. Fabrication of interdigitated electrodes of graphene oxide/silica by femtosecond laser-induced forward transfer for sensing applications. Journal Applied Physics, v. 133, 053103, 2023. 1 - 11| Biblioteca(s): Embrapa Instrumentação. |
| |
| 47. | | PAVINATTO, A.; MERCANTE, L. A.; FACURE, M. H. M.; PENA, R. B.; SANFELICE, R. C.; MATTOSO, L. H. C.; CORREA, D. S. Ultrasensitive biosensor based on polyvinylpyrrolidone/chitosan/reduced graphene oxide electrospun nanofibers for 17alfa - Ethinylestradiol electrochemical detection. Applied Surface Science, v. 458, p. 431-437, 2018.| Biblioteca(s): Embrapa Instrumentação. |
| |
| 48. | | CHRISTINELLI, W. A.; SHIMIZU, F. M.; FACURE, M. H. M.; CERRI, R.; OLIVEIRA JUNIOR, O. N.; CORREA, D. S.; MATTOSO, L. H. C. Two-dimensional MoS2-based impedimetric electronic tongue for the discrimination of endocrine disrupting chemicals using machine learning. Sensors and Actuators: B. Chemical, v. 336, 129696, 2021. 1 - 11| Biblioteca(s): Embrapa Instrumentação. |
| |
| 49. | | MERCANTE, L. A.; FACURE, M. H. M.; LOCILENTO, D.; MIGLIORINI, F. L.; SANFELICE, R. C.; MATTOSO, L. H. C.; CORREA, D. S. Composite membranes based on polymeric nanofibers/graphene oxide with dye sorption capability. In: BRAZIL MRS MEETING - SBPMAT, 15, 2016, Rio de Janeiro. Proceedings... Rio de Janeiro: SBPMat, 2016. não paginado.| Biblioteca(s): Embrapa Instrumentação. |
| |
| 50. | | MERCANTE, L. A.; FACURE, M. H. M.; LOCILENTO, D.; MIGLIORINI, F. L.; SANFELICE, R. C.; MATTOSO, L. H. C.; CORREA, D. S. Composite membranes based on polymeric nanofibers/graphene oxide with dye sorption capability. In: BRAZIL MRS MEETING - SBPMAT, 15, 2016, Rio de Janeiro. Proceedings... Rio de Janeiro: SBPMat, 2016. p. 388.| Biblioteca(s): Embrapa Instrumentação. |
| |
| 52. | | ALVARENGA, A. D.; FACURE, M. H. M.; MONTES-SÁNCHEZ, I.; OLIVEIRA, G. O. S.; LANZA, M. R. V.; MERCANTE, L. A.; CORREA, D. S. Multifunctional and sustainable soot-modified nanofibrous membrane for adsorption, sensing and hydrogen peroxide electrogeneration. Journal of Cleaner Production, n. 422, 138697, 2023.| Biblioteca(s): Embrapa Instrumentação. |
| |
| 53. | | ANDRÉ, R. S.; SANTOS, D. M.; MERCANTE, L. A.; FACURE, M. H. M.; CAMPANA-FILHO, S. P.; MATTOSO, L. H. C.; CORREA, D. S. Nanochitin-based composite films as a disposable ethanol sensor. Journal of Environmental Chemical Engineering, v. 8, 104163, 2020.| Biblioteca(s): Embrapa Instrumentação. |
| |
| 55. | | ANDRE, R. S.; FACURE, M. H. M.; SCHNEIDER, R.; MIGLIORINI, F. L.; SANTOS, D. M. dos; MERCANTE, L. A.; CORREA, D. S. Sensing Materials: Nanofibers Produced by Electrospinning and Solution Blow Spinning. In: Narayan, R. (Ed.), Encyclopedia of Sensors and Biosensors, v. 2, 2023. 521-541| Biblioteca(s): Embrapa Instrumentação. |
| |
| 56. | | SOUSA, L. P. O.; FUKUSHIMA, K. L.; SCAGION, V. P.; FACURE, M. H. M.; CORREA, D. S.; OLIVEIRA, J. E.; FERREIRA, D. D. A principal curves-based method for electronic tongue data analysis. IEEE Sensors Journal, v. 21, n. 4, 2021.| Biblioteca(s): Embrapa Instrumentação. |
| |
| Registros recuperados : 57 | |
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Instrumentação. |
|
Data corrente: |
10/03/2023 |
|
Data da última atualização: |
10/03/2023 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
A - 3 |
|
Autoria: |
GUEDES, M. D. V.; MARQUES, M. S.; BERLITZ, S. J.; FACURE, M. H. M.; CORREA, D. S.; STEFFENS, C.; CONTRI, R. V.; KÜLKAMP-GUERRREIRO, I. C. |
|
Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
|
Título: |
Lamivudine and Zidovudine-Loaded Nanostructures: Green Chemistry Preparation for Pediatric Oral Administration. |
|
Ano de publicação: |
2023 |
|
Fonte/Imprenta: |
Nanomaterials, v. 13, 770, 2023. |
|
Páginas: |
1 - 18 |
|
DOI: |
https://doi.org/10.3390/nano13040770 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Here, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by ultrasonication using monoolein (MN) or phytantriol (PN), which presented narrow size distributions with similar mean particle sizes (~150 nm) determined by laser diffraction. The zeta potential and the pH values of the formulations were around −4.0 mV and 6.0, respectively. MN presented a slightly higher incorporation rate compared to PN. Nanoemulsions were obtained when using monoolein, while cubosomes were obtained when using phytantriol, as confirmed by Small-Angle X-ray Scattering. The formulations enabled drug release control and protection against acid degradation. The drug incorporation was effective and the analyses using an electronic tongue indicated a difference in palatability between the nanotechnological samples in comparison with the drug solutions. In conclusion, PN was considered to have the strongest potential as a novel oral formulation for pediatric HIV treatment |
|
Palavras-Chave: |
Cubosomes; Nanoemulsion. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 01966naa a2200253 a 4500
001 2152254
005 2023-03-10
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/nano13040770$2DOI
100 1 $aGUEDES, M. D. V.
245 $aLamivudine and Zidovudine-Loaded Nanostructures$bGreen Chemistry Preparation for Pediatric Oral Administration.$h[electronic resource]
260 $c2023
300 $a1 - 18
520 $aHere, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by ultrasonication using monoolein (MN) or phytantriol (PN), which presented narrow size distributions with similar mean particle sizes (~150 nm) determined by laser diffraction. The zeta potential and the pH values of the formulations were around −4.0 mV and 6.0, respectively. MN presented a slightly higher incorporation rate compared to PN. Nanoemulsions were obtained when using monoolein, while cubosomes were obtained when using phytantriol, as confirmed by Small-Angle X-ray Scattering. The formulations enabled drug release control and protection against acid degradation. The drug incorporation was effective and the analyses using an electronic tongue indicated a difference in palatability between the nanotechnological samples in comparison with the drug solutions. In conclusion, PN was considered to have the strongest potential as a novel oral formulation for pediatric HIV treatment
653 $aCubosomes
653 $aNanoemulsion
700 1 $aMARQUES, M. S.
700 1 $aBERLITZ, S. J.
700 1 $aFACURE, M. H. M.
700 1 $aCORREA, D. S.
700 1 $aSTEFFENS, C.
700 1 $aCONTRI, R. V.
700 1 $aKÜLKAMP-GUERRREIRO, I. C.
773 $tNanomaterials$gv. 13, 770, 2023.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Instrumentação (CNPDIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
