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| Registros recuperados : 14 | |
| 4. |  | CORREA, A. P. A.; WREGE, M. S. Contribuição da modelagem de distribuição potencial de Copaifera langsdorffi, Aspidosperma polyneuron, Euterpe edulis e Cordia trichotoma para a conservação e recuperação da floresta estacional semidecidual. In: CONGRESSO BRASILEIRO DE AGROMETEOROLOGIA, 18., 2013, Belém, PA. Belém, PA: Sociedade Brasileira de Agrometeorologia, 2013.| Biblioteca(s): Embrapa Florestas. |
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| 9. | | FRITZSONS, E.; MANTOVANI, L. E.; ROSA FILHO, E.; PARRON, L. M.; CORREA, A. P. A. Aplicação da análise de componentes principais a qualidade de água do Rio Capivari, Colombo, Paraná. In: SIMPÓSIO BRASILEIRO DE RECURSOS HÍDRICOS, 18., 2009, Campo Grande. Anais... [Campo Grande: ABRH], 2009. 9 p. CD-ROM.| Biblioteca(s): Embrapa Florestas. |
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| 13. | | AGUIAR, A. V. de; CORREA, A. P. A.; SOUSA, V. A. de; DAROS, T. L.; SHIMIZU, J. Y. Variação genética em progênies de Pinus caribaea var. bahamensis em Barra Velha, SC. In: CONGRESSO BRASILEIRO DE MELHORAMENTO DE PLANTAS, 6., 2011, Búzios. Panorama atual e perspectivas do melhoramento de plantas no Brasil. [Búzios]: SBMP, 2011. 1 CD-ROM.| Biblioteca(s): Embrapa Florestas. |
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| 14. | | CORREA, A. P. A.; AGUIAR, A. V. de; AOKI, H.; MARTINS, E. G.; SOUSA, V. A. de; CARLETTO, R.; FRITZSONS, E. Variabilidade genética em progênies de segunda geração de Grevillea robusta Cunn. em Avaré-SP. In: EVENTO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA FLORESTAS, 8., 2009, Colombo. Anais. Colombo: Embrapa Florestas, 2009. 1 CD-ROM. (Embrapa Florestas. Documentos, 186). EVINCI. Resumo.| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 14 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
21/03/2024 |
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Data da última atualização: |
22/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
KAPRITCHKOFF, R. T. I.; OKINO, C. H.; NICIURA, S. C. M.; BELLO, H. J. S.; MATOS, R. S.; MELITO, G. R.; DONATONI, F. A. B.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
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Afiliação: |
RAFAELA TAMI IKEDA KAPRITCHKOFF, Universidade Estadual Paulista; CINTIA HIROMI OKINO, CPPSE; SIMONE CRISTINA MEO NICIURA, CPPSE; HORNBLENDA JOAQUINA SILVA BELLO; RENATA SILVA MATOS; GLAUCIA ROBERTA MELITO; FLAVIA ALINE BRESSANI DONATONI, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Association of β-globin polymorphisms and tolerance to haemonchosis in ewes and lambs of different sheep breeds. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 328, june 2024, 110163. |
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Páginas: |
8 p. |
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DOI: |
10.1016/j.vetpar.2024.110163 |
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Idioma: |
Inglês |
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Conteúdo: |
Gastrointestinal nematodes (GIN), especially Haemonchus contortus, represent a significant challenge for sheep production. Given the global concern about GIN anthelmintic resistance, alternative control methods able to reduce the dependence on these drugs are highly advisable. Since previous studies have shown that sheep carrying the Hb-A allele of β-globin are more resistant to H. contortus, this study aimed to investigate the relationship between the different haplotypes (Hb-AA, Hb-AB and Hb-BB) and phenotypes in Santa Inês (SI), Texel (TX) and White Dorper (DO) breeds infected with H. contortus. Blood samples were collected from 180 ewes and 123 lambs of the three breeds for DNA extraction followed by qPCR using a hydrolysis probe to identify the β-globin haplotypes. Phenotypic data, including fecal egg count (FEC), packed cell volume (PCV), FAMACHA score and body condition score for ewes and lambs, as well as weight gain for lambs, were collected. The genotypic frequencies of β-globin for ewes and lambs were, respectively: 21.7% and 21.4% Hb-AA, 50% and 50% Hb-AB and 28.3% and 28.6% Hb-BB in SI; 0% and 0% Hb-AA, 18.6% and 9.4% Hb-AB and 81.4% and 90.6% Hb-BB in TX; and 0% and 0% Hb-AA, 13.1% and 0% Hb-AB and 86.9% and 100% Hb-BB in DO. In ewes, mean PCV differed (p<0.05) between the three haplotypes, with higher PCV in Hb-AA animals, followed by Hb-AB and Hb-BB. When considering each breed separately, SI Hb-AA ewes presented higher PCV (p<0.05), highlighting that even in a breed already considered resistant, animals with Hb-AA haplotype showed superior performance. Lambs with the Hb-AA haplotype exhibited a higher (p<0.05) mean PCV compared to those with Hb-AB and Hb-BB. The same pattern was found in SI when analyzing each breed separately. No significant association was found between β-globin haplotypes and FEC, FAMACHA score, body condition score, or weight gain. Nevertheless, given that anemia is the major clinical sign of haemonchosis, our findings on PCV reinforce that sheep carrying the Hb-A allele of β-globin are more tolerant to haemonchosis. This study may support the development of a valuable tool, targeting genetic selection for GIN control, reducing the dependence on anthelmintics and boosting sheep production worldwide. MenosGastrointestinal nematodes (GIN), especially Haemonchus contortus, represent a significant challenge for sheep production. Given the global concern about GIN anthelmintic resistance, alternative control methods able to reduce the dependence on these drugs are highly advisable. Since previous studies have shown that sheep carrying the Hb-A allele of β-globin are more resistant to H. contortus, this study aimed to investigate the relationship between the different haplotypes (Hb-AA, Hb-AB and Hb-BB) and phenotypes in Santa Inês (SI), Texel (TX) and White Dorper (DO) breeds infected with H. contortus. Blood samples were collected from 180 ewes and 123 lambs of the three breeds for DNA extraction followed by qPCR using a hydrolysis probe to identify the β-globin haplotypes. Phenotypic data, including fecal egg count (FEC), packed cell volume (PCV), FAMACHA score and body condition score for ewes and lambs, as well as weight gain for lambs, were collected. The genotypic frequencies of β-globin for ewes and lambs were, respectively: 21.7% and 21.4% Hb-AA, 50% and 50% Hb-AB and 28.3% and 28.6% Hb-BB in SI; 0% and 0% Hb-AA, 18.6% and 9.4% Hb-AB and 81.4% and 90.6% Hb-BB in TX; and 0% and 0% Hb-AA, 13.1% and 0% Hb-AB and 86.9% and 100% Hb-BB in DO. In ewes, mean PCV differed (p<0.05) between the three haplotypes, with higher PCV in Hb-AA animals, followed by Hb-AB and Hb-BB. When considering each breed separately, SI Hb-AA ewes presented higher PCV (p<0.05), highlighting that even in... Mostrar Tudo |
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Palavras-Chave: |
Ovine; Parasite tolerance; Resilience. |
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Thesagro: |
Anemia; Haemonchus Contortus. |
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Thesaurus NAL: |
Genotyping; Haplotypes. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/263903/1/AssociationBGlobin.pdf
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Marc: |
LEADER 03233naa a2200325 a 4500
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008 2024 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2024.110163$2DOI
100 1 $aKAPRITCHKOFF, R. T. I.
245 $aAssociation of β-globin polymorphisms and tolerance to haemonchosis in ewes and lambs of different sheep breeds.$h[electronic resource]
260 $c2024
300 $a8 p.
520 $aGastrointestinal nematodes (GIN), especially Haemonchus contortus, represent a significant challenge for sheep production. Given the global concern about GIN anthelmintic resistance, alternative control methods able to reduce the dependence on these drugs are highly advisable. Since previous studies have shown that sheep carrying the Hb-A allele of β-globin are more resistant to H. contortus, this study aimed to investigate the relationship between the different haplotypes (Hb-AA, Hb-AB and Hb-BB) and phenotypes in Santa Inês (SI), Texel (TX) and White Dorper (DO) breeds infected with H. contortus. Blood samples were collected from 180 ewes and 123 lambs of the three breeds for DNA extraction followed by qPCR using a hydrolysis probe to identify the β-globin haplotypes. Phenotypic data, including fecal egg count (FEC), packed cell volume (PCV), FAMACHA score and body condition score for ewes and lambs, as well as weight gain for lambs, were collected. The genotypic frequencies of β-globin for ewes and lambs were, respectively: 21.7% and 21.4% Hb-AA, 50% and 50% Hb-AB and 28.3% and 28.6% Hb-BB in SI; 0% and 0% Hb-AA, 18.6% and 9.4% Hb-AB and 81.4% and 90.6% Hb-BB in TX; and 0% and 0% Hb-AA, 13.1% and 0% Hb-AB and 86.9% and 100% Hb-BB in DO. In ewes, mean PCV differed (p<0.05) between the three haplotypes, with higher PCV in Hb-AA animals, followed by Hb-AB and Hb-BB. When considering each breed separately, SI Hb-AA ewes presented higher PCV (p<0.05), highlighting that even in a breed already considered resistant, animals with Hb-AA haplotype showed superior performance. Lambs with the Hb-AA haplotype exhibited a higher (p<0.05) mean PCV compared to those with Hb-AB and Hb-BB. The same pattern was found in SI when analyzing each breed separately. No significant association was found between β-globin haplotypes and FEC, FAMACHA score, body condition score, or weight gain. Nevertheless, given that anemia is the major clinical sign of haemonchosis, our findings on PCV reinforce that sheep carrying the Hb-A allele of β-globin are more tolerant to haemonchosis. This study may support the development of a valuable tool, targeting genetic selection for GIN control, reducing the dependence on anthelmintics and boosting sheep production worldwide.
650 $aGenotyping
650 $aHaplotypes
650 $aAnemia
650 $aHaemonchus Contortus
653 $aOvine
653 $aParasite tolerance
653 $aResilience
700 1 $aOKINO, C. H.
700 1 $aNICIURA, S. C. M.
700 1 $aBELLO, H. J. S.
700 1 $aMATOS, R. S.
700 1 $aMELITO, G. R.
700 1 $aDONATONI, F. A. B.
700 1 $aESTEVES, S. N.
700 1 $aCHAGAS, A. C. de S.
773 $tVeterinary Parasitology$gv. 328, june 2024, 110163.
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