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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
Data corrente: |
23/11/2020 |
Data da última atualização: |
23/11/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BIOLCHI, A. M.; OLIVEIRA, D. G. R. de; AMARAL, H. de O.; CAMPOS, G. A. A.; GONÇALVES, J. C.; SOUZA, A. C. B. de; LIMA, M. R.; SILVA, L. P. da; MORTARI, M. R. |
Afiliação: |
ANDRÉIA MAYER BIOLCHI, UNB; DANILO GUSTAVO RODRIGUES DE OLIVEIRA, UNB; HENRIQUE DE OLIVEIRA AMARAL, UNB; GABRIEL AVOHAY ALVES CAMPOS, UNB; JACQUELINE COIMBRA GONÇALVES, UNB; ADOLFO CARLOS BARROS DE SOUZA, UNB; MARCOS ROBALINHO LIMA, UNB; LUCIANO PAULINO DA SILVA, Cenargen; MÁRCIA RENATA MORTARI, UNB. |
Título: |
Fraternine, a novel wasp peptide, protects against motor impairments in 6-OHDA model of parkinsonism. |
Ano de publicação: |
2020 |
Fonte/Imprenta: |
Toxins, v. 12, 0550, 2020. |
DOI: |
https://doi.org/10.3390/toxins12090550 |
Idioma: |
Inglês |
Palavras-Chave: |
Antiparkinsonian activity; Motor behavior; Parkinson's disease; Wasp venom. |
Thesaurus Nal: |
Neuroprotective effect. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00857naa a2200277 a 4500 001 2126952 005 2020-11-23 008 2020 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.3390/toxins12090550$2DOI 100 1 $aBIOLCHI, A. M. 245 $aFraternine, a novel wasp peptide, protects against motor impairments in 6-OHDA model of parkinsonism.$h[electronic resource] 260 $c2020 650 $aNeuroprotective effect 653 $aAntiparkinsonian activity 653 $aMotor behavior 653 $aParkinson's disease 653 $aWasp venom 700 1 $aOLIVEIRA, D. G. R. de 700 1 $aAMARAL, H. de O. 700 1 $aCAMPOS, G. A. A. 700 1 $aGONÇALVES, J. C. 700 1 $aSOUZA, A. C. B. de 700 1 $aLIMA, M. R. 700 1 $aSILVA, L. P. da 700 1 $aMORTARI, M. R. 773 $tToxins$gv. 12, 0550, 2020.
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Registro Completo
Biblioteca(s): |
Embrapa Semiárido. |
Data corrente: |
16/07/2020 |
Data da última atualização: |
16/07/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
DUARTE, D. S.; NAASCIMENTO, J. A. de A.; BRITTO, D. de. |
Afiliação: |
Dirliane Santos Duarte, UNIVASF; José Augusto de Almeida Nascimento, UFPE; DOUGLAS DE BRITTO, CPATSA. |
Título: |
Scale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Ciência e Agrotecnologia, v. 43, e023819, 2019. |
ISSN: |
1981-1829 |
DOI: |
http://dx.doi.org/10.1590/1413-7054201943023819 |
Idioma: |
Inglês |
Conteúdo: |
Given the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3 . The NP were characterized for yield, particle size, morphology, encapsulation efficiency and release profile. In general, the increase in scale did not influence these parameters. It is found a close similarity for NP size value between the 0.1 and 10.0 dm3 reactional volumes. For example, for the blank control, the size was 155±6 and 227±118 nm respectively for 0.1 and 10.0 dm3 reactional volumes. Similarly for the encapsulated acerola byproduct extract (373±44 and 400±83 nm) and ascorbic acid (279±29 and 217±29 nm). For the encapsulated skin grape extract, the size decreased sharply from 1040 to 308 nm. The yield per volume ratio was about 1.3 mg cm-3. Additional analysis for NP with encapsulated skin grape extract, by Scanning Electronic Microscopy, showed uniformly distributed spherical structures and the release profile was similar for all reactional volumes. Thus, the system is suitable for scale-up for NP production. MenosGiven the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3 . The NP were characterized for yield, particle size, morphology, encapsulation efficiency and release profile. In general, the increase in scale did not influence these parameters. It is found a close similarity for NP size value between the 0.1 and 10.0 dm3 reactional volumes. For example, for the blank control, the size was 155±6 and 227±118 nm respectively for 0.1 and 10.0 dm3 reactional volumes. Similarly for the encapsulated acerola byproduct extract (373±44 and 400±83 nm) and ascorbic acid (279±29 and 217±29 nm). For the encapsulated skin grape extract, the size decreased sharply from 1040 to 308 nm. The yield per volume ratio was about 1.3 mg cm-3. Additional analysis for NP with encapsulated skin grape extract, by Scanning Electronic Microscopy, showed uniformly distributed ... Mostrar Tudo |
Palavras-Chave: |
Agroindustria; Encapsulamento; Nanopartículas; Polifenóis; Quitosana. |
Thesagro: |
Subproduto; Vitamina C. |
Thesaurus NAL: |
Byproducts; Polyphenols; Vitamin content. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/214651/1/Scale-up-in-the-synthesis-of-nanoparticles-2019.pdf
|
Marc: |
LEADER 02496naa a2200289 a 4500 001 2123889 005 2020-07-16 008 2019 bl uuuu u00u1 u #d 022 $a1981-1829 024 7 $ahttp://dx.doi.org/10.1590/1413-7054201943023819$2DOI 100 1 $aDUARTE, D. S. 245 $aScale-up in the synthesis of nanoparticles for encapsulation of agroindustrial active principles.$h[electronic resource] 260 $c2019 520 $aGiven the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3 . The NP were characterized for yield, particle size, morphology, encapsulation efficiency and release profile. In general, the increase in scale did not influence these parameters. It is found a close similarity for NP size value between the 0.1 and 10.0 dm3 reactional volumes. For example, for the blank control, the size was 155±6 and 227±118 nm respectively for 0.1 and 10.0 dm3 reactional volumes. Similarly for the encapsulated acerola byproduct extract (373±44 and 400±83 nm) and ascorbic acid (279±29 and 217±29 nm). For the encapsulated skin grape extract, the size decreased sharply from 1040 to 308 nm. The yield per volume ratio was about 1.3 mg cm-3. Additional analysis for NP with encapsulated skin grape extract, by Scanning Electronic Microscopy, showed uniformly distributed spherical structures and the release profile was similar for all reactional volumes. Thus, the system is suitable for scale-up for NP production. 650 $aByproducts 650 $aPolyphenols 650 $aVitamin content 650 $aSubproduto 650 $aVitamina C 653 $aAgroindustria 653 $aEncapsulamento 653 $aNanopartículas 653 $aPolifenóis 653 $aQuitosana 700 1 $aNAASCIMENTO, J. A. de A. 700 1 $aBRITTO, D. de 773 $tCiência e Agrotecnologia$gv. 43, e023819, 2019.
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