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Registro Completo |
Biblioteca(s): |
Embrapa Agroenergia. |
Data corrente: |
15/03/2019 |
Data da última atualização: |
18/11/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A. |
Afiliação: |
Raquel de Cássia dos Santos; Flavia Bonamina; Larissa Lucena Périco; Vinícius Peixoto Rodrigues; Ana Caroline Zanatta; CLENILSON MARTINS RODRIGUES, CNPAE; Miriam Sannomiya; Matheus Aparecido dos Santos Ramos; Bruna Vidal Bonifácio; Taís Maria Bauab; Jorge Tamashiro; Lúcia Regina Machado da Rocha; Wagner Vilegas; Clelia Akiko Hiruma-Lima. |
Título: |
Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 111, p. 1112-1123, 2019. |
Idioma: |
Inglês |
Conteúdo: |
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric mucosal MPO, IL 1-β and TNFalpha, as well as an elevation in IL-10 and GSH content. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue. All these results confirm that the rich phytochemical diversity of B. intermedia contributes to the pharmacological actions of this medicinal plant on the gastrointestinal tract in addition to its activity against H. pylori. MenosByrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, bo... Mostrar Tudo |
Palavras-Chave: |
Healing effect; Peptic ulcer. |
Thesaurus Nal: |
Anti-inflammatory activity. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/194314/1/CLENILSON-039-Biomedicine-and-Pharmacotherapy-V.111-Issue.3-2019-1112-1123.pdf
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Marc: |
LEADER 03557naa a2200313 a 4500 001 2107125 005 2019-11-18 008 2019 bl uuuu u00u1 u #d 100 1 $aSANTOS, R. de C. dos 245 $aByrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities.$h[electronic resource] 260 $c2019 520 $aByrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric mucosal MPO, IL 1-β and TNFalpha, as well as an elevation in IL-10 and GSH content. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue. All these results confirm that the rich phytochemical diversity of B. intermedia contributes to the pharmacological actions of this medicinal plant on the gastrointestinal tract in addition to its activity against H. pylori. 650 $aAnti-inflammatory activity 653 $aHealing effect 653 $aPeptic ulcer 700 1 $aBONAMINA, F. 700 1 $aPÉRICO, L. L. 700 1 $aRODRIGUES, V. P. 700 1 $aZANATTA, A. C. 700 1 $aRODRIGUES, C. M. 700 1 $aSANNOMIYA, M. 700 1 $aRAMOS. M. A. dos S. 700 1 $aBONIFÁCIO, B. V. 700 1 $aBAUAB, T. M. 700 1 $aTAMASHIRO, J. 700 1 $aROCHA, L. R. M. da 700 1 $aVILEGAS, W. 700 1 $aHIRUMA-LIMA, C. A. 773 $tBiomedicine & Pharmacotherapy$gv. 111, p. 1112-1123, 2019.
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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Registro Completo
Biblioteca(s): |
Embrapa Agricultura Digital. |
Data corrente: |
08/02/2010 |
Data da última atualização: |
15/01/2020 |
Tipo da produção científica: |
Artigo em Anais de Congresso / Nota Técnica |
Autoria: |
OLIVEIRA, D.; CUNHA, L.; TOMAZ, L.; PEREIRA, V.; MATTOSO, M. |
Afiliação: |
DANIEL DE OLIVEIRA, UFRJ; LUIZ MANOEL SILVA CUNHA, CNPTIA; LUIZ TOMAZ, UFRJ; VINICIUS PEREIRA, UFRJ; MARTA MATTOSO, UFRJ. |
Título: |
Using ontologies to support deep water oil exploration scientific workflows. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
In: IEEE COMPUTER CONGRESS SERVICES, 2009, San Diego. Proceedings... Washington, DC: IEEE Computer Society, 2009. |
Páginas: |
p. 364-367. |
DOI: |
10.1109/SERVICES-I.2009.17 |
Idioma: |
Português |
Conteúdo: |
Scientific experiments generate a large amount of data to be processed and analyzed. As the amount of data increases, the way engineers define their own experiments, analyze the output and share them is becoming complex to manage. Scientific Workflow Management Systems (WfMS) are being used to orchestrate a sequence of programs, services and resources, defined by scientific workflows. However, current WfMS are focused on the workflow execution and present limitations on the semantic support to design the experiment. These tools lack on semantic descriptions of available resources to design scientific workflow. This paper presents an ontology for deep water oil exploration workflow. This ontology has been used to present some semantic concepts to help defining a workflow to be further executed by a WfMS. We evaluate this semantic support on a real workflow that calculates fatigue on risers in deep water oil platforms. The results reinforce the benefits of semantic support over program chaining in manual workflow design. |
Palavras-Chave: |
Ontologia; Ontologies; Scientific workflows; Semântica; Semantics. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 01774nam a2200241 a 4500 001 1657083 005 2020-01-15 008 2009 bl uuuu u00u1 u #d 024 7 $a10.1109/SERVICES-I.2009.17$2DOI 100 1 $aOLIVEIRA, D. 245 $aUsing ontologies to support deep water oil exploration scientific workflows.$h[electronic resource] 260 $aIn: IEEE COMPUTER CONGRESS SERVICES, 2009, San Diego. Proceedings... Washington, DC: IEEE Computer Society$c2009 300 $ap. 364-367. 520 $aScientific experiments generate a large amount of data to be processed and analyzed. As the amount of data increases, the way engineers define their own experiments, analyze the output and share them is becoming complex to manage. Scientific Workflow Management Systems (WfMS) are being used to orchestrate a sequence of programs, services and resources, defined by scientific workflows. However, current WfMS are focused on the workflow execution and present limitations on the semantic support to design the experiment. These tools lack on semantic descriptions of available resources to design scientific workflow. This paper presents an ontology for deep water oil exploration workflow. This ontology has been used to present some semantic concepts to help defining a workflow to be further executed by a WfMS. We evaluate this semantic support on a real workflow that calculates fatigue on risers in deep water oil platforms. The results reinforce the benefits of semantic support over program chaining in manual workflow design. 653 $aOntologia 653 $aOntologies 653 $aScientific workflows 653 $aSemântica 653 $aSemantics 700 1 $aCUNHA, L. 700 1 $aTOMAZ, L. 700 1 $aPEREIRA, V. 700 1 $aMATTOSO, M.
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