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Registros recuperados : 10 | |
3. | | RODRIGUES, F. C.; SANTOS, A. T. L. dos; CRUZ, R. P. da; ALMEIDA-BEZERRA, J. W.; COUTINHO, H. D. M.; RIBEIRO, P. R. V.; BRITO, E. S. de; MORAIS-BRAGA, M. F. B.; OLIVEIRA, A. F. M. de. Antimicrobial activity, modulatory effect and phytochemical analysis of Sida galheirensis Ulbr. (Malvaceae). South African Journal of Botany, v. 147, 286-293, 2022. Biblioteca(s): Embrapa Agroindústria Tropical. |
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4. | | MARTINS, A. F.; VIEIRA, E. A.; KOPP, M. M.; LUZ, V. K. da; CARVALHO, M. F. de; CASTELO BRANCO, J. S.; CRUZ, R. P. da; CARVALHO, F. I. F. de; OLIVEIRA, A. C. de. Caracterização de famílias mutantes de arroz para tolerância ao frio nos períodos vegetativo e reprodutivo. Bragantia, Campinas, v. 66, n. 2, p. 227-233, 2007. Biblioteca(s): Embrapa Cerrados. |
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5. | | BEZERRA, C. F.; ROCHA, J. E.; SILVA, M. K. N.; FREITAS, T. S.; SOUSA, A. K.; SANTOS, A. T. L. dos; CRUZ, R. P. da; FERREIRA, M. H.; SILVA, J. C. P. da; MACHADO, A. J. T.; CARNEIRO, J. N. P.; SALES, D. L.; COUTINHO, H. D. M.; RIBEIRO, P. R. V.; BRITO, E. S. de; MORAIS-BRAGA, M. F. Analysis by UPLC-MS-QTOF and antifungal activity of guava (Psidium guajava L.). Food and Chemical Toxicology, v. 119, p. 122-132, 2018. Biblioteca(s): Embrapa Agroindústria Tropical. |
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6. | | BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F. Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022. Biblioteca(s): Embrapa Alimentos e Territórios. |
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7. | | SANTOS, J. F. S. dos; ROCHA, J. E.; BEZERRA, C. F.; SILVA, M. K. do N.; MATOS, Y. M. L. S. de; FREITAS, T. S. de; SANTOS, A. T. L. dos; CRUZ, R. P. da; MACHADO, A. J. T.; RODRIGUES, T. H. S.; BRITO, E. S. de; SALES, D. L.; ALMEIDA, W. de O.; COSTA, J. G. M. da; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B. Chemical composition, antifungal activity and potential anti-virulence evaluation of the Eugenia uniflora essential oil against Candida spp. Food Chemistry, v. 261, p. 233-239, 2018. Biblioteca(s): Embrapa Agroindústria Tropical. |
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8. | | PINHEIRO, J. C. A.; SOUZA, C. E. S. DE; RIBEIRO, D. A.; SILVA, A. DE A.; SILVA, V. B. DA; SANTOS, A. T. L. DOS; FONSECA, V. J. A.; MACÊDO, D. G. DE; CRUZ, R. P. DA; BEZERRA, J. W. A.; MACHADO, A. J. T.; FREITAS, T. S. DE; BRITO, E. S. de; RIBEIRO, P. R. V.; COSTA, J. G. M. DA; COUTINHO, H. D. M.; KOWALSKA, G.; ROWINSKI, R.; KOWALSKI, R.; BRAGA, M. F. B. M. LC-MS analysis and antifungal activity of Turnera subulata Sm. Plants, v. 12, n. 415, 2023. 12 p. Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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9. | | BEZERRA, C. F.; ROCHA, J. E.; SILVA, M. K. do N.; FREITAS, T. S. de; SOUSA, A. K. de; CARNEIRO, J. N. P.; LEAL, A. L. A. B.; SANTOS, A. T. L. dos; CRUZ, R. P. da; RODRIGUES, A. S.; SALES, D. L.; COUTINHO, H. D. M.; RIBEIRO, P. R. V.; BRITO, E. S. de; COSTA, J. G. M. da; MENEZES, R. R. A. de; ALMEIDA, W. de O.; MORAIS-BRAGA, M. F. B. UPLC-MS-ESI-QTOF analysis and anti-Candida activity of fractions from Psidium guajava L. South African Journal of Botany, 131, pp. 421-427, 2020. Biblioteca(s): Embrapa Agroindústria Tropical. |
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10. | | SANTOS, A. T. L. dos; CARNEIRO, J. N. P.; CRUZ, R. P. da; SALES, D. L.; PINHEIRO, J. C. A.; FREITAS, M. A. de; KERNTOPF, M. R.; DELMONDES, G. de A.; RIBEIRO, P. R. V.; BRITO, E. S. de; BATISTA, F. L. A.; MAGALHÃES, F. E. A.; PITA NETO, I. C.; BRAGA, M. F. B. M.; KOWALSKI, R.; KOWALSKA, G.; SZOPA, A.; BAJ, T.; COUTINHO, H. D. M. UPLC-MS-ESI-QTOF analysis and antifungal activity of aqueous extracts of Spondias tuberosa. Molecules, Basel, v. 28, n. 1, art. 305, Jan. 2023. 14 p. Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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Registros recuperados : 10 | |
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Registro Completo
Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
Data corrente: |
17/11/2023 |
Data da última atualização: |
17/11/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 4 |
Autoria: |
PINHEIRO, J. C. A.; SOUZA, C. E. S. DE; RIBEIRO, D. A.; SILVA, A. DE A.; SILVA, V. B. DA; SANTOS, A. T. L. DOS; FONSECA, V. J. A.; MACÊDO, D. G. DE; CRUZ, R. P. DA; BEZERRA, J. W. A.; MACHADO, A. J. T.; FREITAS, T. S. DE; BRITO, E. S. de; RIBEIRO, P. R. V.; COSTA, J. G. M. DA; COUTINHO, H. D. M.; KOWALSKA, G.; ROWINSKI, R.; KOWALSKI, R.; BRAGA, M. F. B. M. |
Afiliação: |
JACQUELINE COSMO ANDRADE-PINHEIRO, Regional University of Cariri; CELESTINA ELBA SOBRAL DE SOUZA, Regional University of Cariri; DAIANY ALVES RIBEIRO, Regional University of Cariri; ANDRESSA DE ALENCAR SILVA, Regional University of Cariri; VIVIANE BEZERRA DA SILVA, Federal University of Pernambuco; ANTONIA THASSYA LUCAS DOS SANTOS, Regional University of Cariri; VICTOR JUNO ALENCAR FONSECA, Regional University of Cariri; DELMACIA GONÇALVES DE MACÊDO, Regional University of Cariri; RAFAEL PEREIRA DA CRUZ, Regional University of Cariri; JOSÉ WEVERTON ALMEIDA-BEZERRA, Regional University of Cariri; ANTONIO JÚDSON TARGINO MACHADO, Regional University of Cariri; THIAGO SAMPAIO DE FREITAS, Regional University of Cariri; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; JOSÉ GALBERTO MARTINS DA COSTA, Regional University of Cariri; HENRIQUE DOUGLAS MELO COUTINHO, Regional University of Cariri; GRAZYNA KOWALSKA, University of Life Sciences in Lublin; RAFAL ROWINSKI, University of Life Sciences in Lublin; RADOSLAW KOWALSKI, University of Life Sciences in Lublin; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, Regional University of Cariri. |
Título: |
LC-MS analysis and antifungal activity of Turnera subulata Sm. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Plants, v. 12, n. 415, 2023. |
Páginas: |
12 p. |
DOI: |
10.3390/plants12020415 |
Idioma: |
Inglês |
Conteúdo: |
Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors. |
Palavras-Chave: |
Antifungal; Antifúngico; Extract; Extrair; Levedura; Virulência. |
Thesaurus NAL: |
Antifungal agents; Extracts; Virulence; Yeasts. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1158504/1/LC-MS-Analysis.pdf
|
Marc: |
LEADER 02755naa a2200493 a 4500 001 2158504 005 2023-11-17 008 2023 bl uuuu u00u1 u #d 024 7 $a10.3390/plants12020415$2DOI 100 1 $aPINHEIRO, J. C. A. 245 $aLC-MS analysis and antifungal activity of Turnera subulata Sm.$h[electronic resource] 260 $c2023 300 $a12 p. 520 $aFungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors. 650 $aAntifungal agents 650 $aExtracts 650 $aVirulence 650 $aYeasts 653 $aAntifungal 653 $aAntifúngico 653 $aExtract 653 $aExtrair 653 $aLevedura 653 $aVirulência 700 1 $aSOUZA, C. E. S. DE 700 1 $aRIBEIRO, D. A. 700 1 $aSILVA, A. DE A. 700 1 $aSILVA, V. B. DA 700 1 $aSANTOS, A. T. L. DOS 700 1 $aFONSECA, V. J. A. 700 1 $aMACÊDO, D. G. DE 700 1 $aCRUZ, R. P. DA 700 1 $aBEZERRA, J. W. A. 700 1 $aMACHADO, A. J. T. 700 1 $aFREITAS, T. S. DE 700 1 $aBRITO, E. S. de 700 1 $aRIBEIRO, P. R. V. 700 1 $aCOSTA, J. G. M. DA 700 1 $aCOUTINHO, H. D. M. 700 1 $aKOWALSKA, G. 700 1 $aROWINSKI, R. 700 1 $aKOWALSKI, R. 700 1 $aBRAGA, M. F. B. M. 773 $tPlants$gv. 12, n. 415, 2023.
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