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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
01/02/2018 |
Data da última atualização: |
07/11/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
GEISTLINGER, L.; SILVA, V. H. da; CESAR, A. S. M.; TIZIOTO, P. C.; WALDRON, L.; ZIMMER, R.; REGITANO, L. C. de A.; COUTINHO, L. L. |
Afiliação: |
Ludwig Geistlinger, Bolsista/Embrapa Pecuária Sudeste; Vinicius Henrique da Silva, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; Polyana Cristine Tizioto, ESALQ/USP; Levi Waldron, University of New York; Ralf Zimmer, Ludwig Maximilians Universität München; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Luiz Lehmann Coutinho, ESALQ/USP. |
Título: |
Widespread modulation of gene expression by copy number variation in skeletal muscle. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Scientific Reports, v. 8, n. 1399, p. 1-11, jan. 2018. |
DOI: |
10.1038/s41598-018-19782-4 |
Idioma: |
Inglês |
Conteúdo: |
Copy number variation (CNV) is a frequently observed deviation from the diploid state due to duplication or deletion of genomic regions. Although intensively analyzed for association with diseases and production traits, the specific mechanisms and extent by which such variations affect the phenotype are incompletely understood. We present an integrative study on CNV and genome-wide gene expression in Brazilian Bos indicus cattle. We analyzed CNVs inferred from SNP-chip data for effects on gene expression measured with RNA-seq in skeletal muscle samples of 183 steers. Local effects, where expression changes coincided with CNVs in the respective genes, were restricted to immune genes. Distal effects were attributable to several high-impact CNVs that modulated remote expression in an orchestrated and intertwined fashion. These CNVs were located in the vicinity of major skeletal muscle pathway regulators and associated genes were enriched for proteolysis, autophagy, and muscle structure development. From association analysis between CNVs and several meat quality and production traits, we found CNV-associated expression effects to also manifest at the phenotype level. Based on genome sequences of the population founders, we further demonstrate that CNVs with impact on expression and phenotype are passed on from one generation to another. |
Palavras-Chave: |
Agricultural genetics; Nellore cattle. |
Thesaurus Nal: |
gene expression. |
Categoria do assunto: |
G Melhoramento Genético |
Marc: |
LEADER 02111naa a2200253 a 4500 001 2086932 005 2018-11-07 008 2018 bl uuuu u00u1 u #d 024 7 $a10.1038/s41598-018-19782-4$2DOI 100 1 $aGEISTLINGER, L. 245 $aWidespread modulation of gene expression by copy number variation in skeletal muscle.$h[electronic resource] 260 $c2018 520 $aCopy number variation (CNV) is a frequently observed deviation from the diploid state due to duplication or deletion of genomic regions. Although intensively analyzed for association with diseases and production traits, the specific mechanisms and extent by which such variations affect the phenotype are incompletely understood. We present an integrative study on CNV and genome-wide gene expression in Brazilian Bos indicus cattle. We analyzed CNVs inferred from SNP-chip data for effects on gene expression measured with RNA-seq in skeletal muscle samples of 183 steers. Local effects, where expression changes coincided with CNVs in the respective genes, were restricted to immune genes. Distal effects were attributable to several high-impact CNVs that modulated remote expression in an orchestrated and intertwined fashion. These CNVs were located in the vicinity of major skeletal muscle pathway regulators and associated genes were enriched for proteolysis, autophagy, and muscle structure development. From association analysis between CNVs and several meat quality and production traits, we found CNV-associated expression effects to also manifest at the phenotype level. Based on genome sequences of the population founders, we further demonstrate that CNVs with impact on expression and phenotype are passed on from one generation to another. 650 $agene expression 653 $aAgricultural genetics 653 $aNellore cattle 700 1 $aSILVA, V. H. da 700 1 $aCESAR, A. S. M. 700 1 $aTIZIOTO, P. C. 700 1 $aWALDRON, L. 700 1 $aZIMMER, R. 700 1 $aREGITANO, L. C. de A. 700 1 $aCOUTINHO, L. L. 773 $tScientific Reports$gv. 8, n. 1399, p. 1-11, jan. 2018.
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Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
Biblioteca(s): |
Embrapa Cerrados. |
Data corrente: |
27/04/2010 |
Data da última atualização: |
06/07/2017 |
Tipo da produção científica: |
Folder/Folheto/Cartilha |
Autoria: |
SOUSA, S. R.; AQUINO, F. de G.; OLIVEIRA FILHO, E. C. de; MUNIZ, D. H. de F.; CRUZ, C. J. D. da; VARGAS, L. M. P. |
Afiliação: |
FABIANA DE GOIS AQUINO, CPAC; EDUARDO CYRINO DE OLIVEIRA FILHO, CPAC; DAPHNE HELOISA DE FREITAS MUNIZ, CPAC; LUCILIA MARIA PARRON VARGAS, CNPF. |
Título: |
Caracterização da qualidade da água na área de proteção de manancial Mestre D'Armas, Distrito Federal (2009). |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
Planaltina, DF: Embrapa Cerrados, 2009. |
Descrição Física: |
1 folder. |
Idioma: |
Português |
Palavras-Chave: |
Federal District. |
Thesagro: |
Água; Impacto Ambiental; Qualidade. |
Thesaurus NAL: |
Brazil; environmental impact; water quality. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/78123/1/p2009-020.pdf
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Marc: |
LEADER 00745nam a2200253 a 4500 001 1737086 005 2017-07-06 008 2009 bl uuuu u0uu1 u #d 100 1 $aSOUSA, S. R. 245 $aCaracterização da qualidade da água na área de proteção de manancial Mestre D'Armas, Distrito Federal (2009). 260 $aPlanaltina, DF: Embrapa Cerrados$c2009 300 $c1 folder. 650 $aBrazil 650 $aenvironmental impact 650 $awater quality 650 $aÁgua 650 $aImpacto Ambiental 650 $aQualidade 653 $aFederal District 700 1 $aAQUINO, F. de G. 700 1 $aOLIVEIRA FILHO, E. C. de 700 1 $aMUNIZ, D. H. de F. 700 1 $aCRUZ, C. J. D. da 700 1 $aVARGAS, L. M. P.
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