Data/hora: 23/06/2024 17:43:33

Biblioteca(s): | Embrapa Instrumentação.
Data corrente: | 06/07/2021
Data da última atualização: | 10/06/2022
Autoria: | CORREIA, L. A. A.; GARCIA, R. S.; REAL, C. C.; UZUELI, D. H.; SÁ, U. L. F.; MARQUES, F. L. N.; COLNAGO, L. A.; ESPÓSITO, B. P.
Afiliação: | LUIZ ALBERTO COLNAGO, CNPDIA.
Título: | Development of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model.
Ano de publicação: | 2021
Fonte/Imprenta: | Chemical Papers, v. 75, 2021.
Páginas: | 1157?1163
ISSN: | 1336-9075
DOI: | https://doi.org/10.1007/s11696-020-01374-0
Idioma: | Inglês
Conteúdo: | The linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high afnity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7–10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers 68Ga(BSA-DFO) and 89Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging.
Palavras-Chave: | Albumin; Desferrioxamine; Gallium-68; Zirconium-89.
Categoria do assunto: | --
Registro original: | Embrapa Instrumentação (CNPDIA)
Exemplares: | CNPDIA - (17816-1) - UPC - AP - DD - PROCI.21/71 -  - 2021/71 - DIS