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| 5. |  | CASTRO, V. L. S. S. de; BADIN, C.; CHIORATO S.; MATA, A. Estudo do potencial teratogenico de dois agroquimicos (Methamidophos e mancozeb) em ratos. In: CONGRESSO BRASILEIRO DE TOXICOLOGIA, 9., 1995, Ribeirao Preto, SP. Revista Brasileira de Toxicologia, Ribeirao Preto, Sao Paulo, v.8, n.1, p.12, 1995. Resumo. ref.4.6.81| Biblioteca(s): Embrapa Meio Ambiente. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
09/04/2019 |
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Data da última atualização: |
09/04/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, V. L. de; CHIORATO, S. H.; PINTO, N. F. |
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Afiliação: |
VERA LUCIA DE CASTRO, CNPMA; SELMA H. CHIORATO, USP/ SP; NADIA F. PINTO, PUCC/CAMPINAS. |
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Título: |
Relevance of developmental testing of exposure to methamidophos during gestation to its toxicology evaluation. |
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Ano de publicação: |
2000 |
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Fonte/Imprenta: |
Toxicology Letters, v.118, p. 93?102, 2000. |
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Idioma: |
Inglês |
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Conteúdo: |
The organophosphate insecticide (OP) are known to be able to promote cholinergic toxicity related to neurobehavioral findings. The measures of cholinesterase activity are the most common index of its action. The influence was evaluated, of the OP methamidophos (1.0 mg/kg), by oral exposure during gestational organogenesis of rats, on maturational and behavioral aspects of offspring development. This dose did not promote evidence of maternal toxicity. The pesticide did not affect body weight gain of the dams and offspring, but interfered with the offspring?s physical and maturational development landmarks according to age. The behavioral performance of the offspring with or without a pharmacological challenge was tested at different postnatal days (pnd 14, 21 and 40) in an open-field apparatus. The results showed a large standard deviation that prejudiced the conclusions. There were no observed alterations in the swimming behavior tested also at pnd 7, 14 and 21. As long as the obtained results showed some subtle effects on rat development, the data, as possible additional effect biomarkers for risk analysis, will aid further studies of the embryo-feto-toxic potential of OP exposure. © 2000 Elsevier Science Ireland Ltd. All rights reserved. |
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Thesaurus NAL: |
Biomarkers; Gestation period; Methamidophos; Rats. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01835naa a2200193 a 4500
001 2108050
005 2019-04-09
008 2000 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. de
245 $aRelevance of developmental testing of exposure to methamidophos during gestation to its toxicology evaluation.$h[electronic resource]
260 $c2000
520 $aThe organophosphate insecticide (OP) are known to be able to promote cholinergic toxicity related to neurobehavioral findings. The measures of cholinesterase activity are the most common index of its action. The influence was evaluated, of the OP methamidophos (1.0 mg/kg), by oral exposure during gestational organogenesis of rats, on maturational and behavioral aspects of offspring development. This dose did not promote evidence of maternal toxicity. The pesticide did not affect body weight gain of the dams and offspring, but interfered with the offspring?s physical and maturational development landmarks according to age. The behavioral performance of the offspring with or without a pharmacological challenge was tested at different postnatal days (pnd 14, 21 and 40) in an open-field apparatus. The results showed a large standard deviation that prejudiced the conclusions. There were no observed alterations in the swimming behavior tested also at pnd 7, 14 and 21. As long as the obtained results showed some subtle effects on rat development, the data, as possible additional effect biomarkers for risk analysis, will aid further studies of the embryo-feto-toxic potential of OP exposure. © 2000 Elsevier Science Ireland Ltd. All rights reserved.
650 $aBiomarkers
650 $aGestation period
650 $aMethamidophos
650 $aRats
700 1 $aCHIORATO, S. H.
700 1 $aPINTO, N. F.
773 $tToxicology Letters$gv.118, p. 93?102, 2000.
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