Data/hora: 21/06/2024 14:24:03

Biblioteca(s): | Embrapa Amazônia Ocidental; Embrapa Meio Ambiente.
Data corrente: | 25/11/2021
Data da última atualização: | 10/06/2022
Autoria: | CORDEIRO, R. P.; BRAGA, P. A. de C.; JONSSON, C. M.; BRANDÃO, F. R.; CHAGAS, E. C.; REYES, F. G. R.
Afiliação: | RAFAELLE PEREIRA CORDEIRO, UNICAMP; PATRÍCIA APARECIDA DE CAMPOS BRAGA, UNICAMP; CLAUDIO MARTIN JONSSON, CNPMA; FRANMIR RODRIGUES BRANDÃO, Bolsista CPAA; EDSANDRA CAMPOS CHAGAS, CPAA; FELIX GUILLERMO REYES REYES, UNICAMP.
Título: | Therapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui (Colossoma macropomum) parasitized by acanthocephalan (Neoechinorhynchus buttnerae).
Ano de publicação: | 2022
Fonte/Imprenta: | Aquaculture Research, v. 53, n. 4, p. 1446-1455, 2022.
DOI: | https://doi.org/10.1111/are.15677
Idioma: | Inglês
Conteúdo: | The therapeutic efficacy of different doses of albendazole (ABZ) in the treatment of infection by acanthocephalan (Neoechinorhynchus buttnerae) in tambaqui (Colossoma macropomum) was evaluated. The bioaccumulation of ABZ and its main metabolites in the target tissue (muscle plus skin in natural proportions) was also evaluated. The fish received a daily dose of 10, 20 or 30 mg ABZ kg-1 bw via medicated feed for 34 days. Incorporation of ABZ in the fish feed was performed by coating with ethyl cellulose (EC) (0.75% w/w). The quantitation of ABZ residues and its metabolites in the target tissue was done using a validated ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analytical method. In relation with the therapeutic efficacy, no statistically difference was found between the treated groups. The total residue (sum of ABZ residues and its metabolites) in the target tissue at steady-state was significantly higher for the high dose. Biomagnification factors in all treatments were of low values, indicating that ABZ and its metabolites do not offer the risk of bioaccumulation in the target tissue. Thus, ABZ dose of 10 mg kg-1 bw is recommend. However, the effect of feed coating on treatment effectiveness and bioaccumulation of albendazole relative to an uncoated feed, and joint therapeutic studies of ABZ with anthelmintic natural products are recommended to be conducted.
Palavras-Chave: | Acanthocephalan; Neoechinorhynchus buttnerae; Therapeutic efficacy.
Thesagro: | Colossoma Macropomum; Tambaqui; Verminose.
Thesaurus Nal: | Albendazole; Bioaccumulation; Freshwater fish.

Categoria do assunto:

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H Saúde e Patologia

Registro original: | Embrapa Meio Ambiente (CNPMA)

Exemplares:

CPAA - (38590-1) - UPC - AP - DD -  -  -  - DIS
CNPMA - (17046-1) - UPC - AP - DD -  -  -  - DIS