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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
30/11/2023 |
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Autoria: |
HUANG, T. W.; CARLSON, J. R.; BRAY, T. M.; BRADLEY, B. J. |
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Afiliação: |
THOMAS W. HUANG, Department of Animal Sciences. Washington State University; TAMMY M. BRAY; BRUCE J. BRADLEY. |
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Título: |
3-methylindole-induced pulmonary injury in goats |
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Ano de publicação: |
1977 |
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Fonte/Imprenta: |
American Journal of Pathology, v. 87, n. 3, p. 647-666, Jun. 1977. |
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Idioma: |
Inglês |
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Conteúdo: |
Ruminal administration of 3-methylindole in goats severe pulmonary edema and respiratory distress. Electron microscopic studies of lungs reveal extensive degeneration and necrosis of alveolar membranous pneumocytes and bronchiolar epithelium. The necrosis of the pneumocytes is followed by proliferation of granular pneumocytes, which repopulate the alveolar basal lamina scaffold. 3-Methylindole may also induce proliferation of smooth endoplasmic reticulum in the remaining membranous pneumocytes and nonciliated columnar cells, indicating that these two cell types are involved in the xenobiotic function of the lung. The results suggest that 3-methylindole in cigarette smoke may play an important role in the pathogenesis of small airway disease and emphysema, and that patients with severe liver diseases or portocaval shunt may be predisposed to diffuse alveolar damage by 3-methylindole produced in the intestinal tract. |
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Palavras-Chave: |
Sistema respiratorio. |
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Thesagro: |
Caprino; Doença. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01463naa a2200193 a 4500
001 1520762
005 2023-11-30
008 1977 bl uuuu u00u1 u #d
100 1 $aHUANG, T. W.
245 $a3-methylindole-induced pulmonary injury in goats$h[electronic resource]
260 $c1977
520 $aRuminal administration of 3-methylindole in goats severe pulmonary edema and respiratory distress. Electron microscopic studies of lungs reveal extensive degeneration and necrosis of alveolar membranous pneumocytes and bronchiolar epithelium. The necrosis of the pneumocytes is followed by proliferation of granular pneumocytes, which repopulate the alveolar basal lamina scaffold. 3-Methylindole may also induce proliferation of smooth endoplasmic reticulum in the remaining membranous pneumocytes and nonciliated columnar cells, indicating that these two cell types are involved in the xenobiotic function of the lung. The results suggest that 3-methylindole in cigarette smoke may play an important role in the pathogenesis of small airway disease and emphysema, and that patients with severe liver diseases or portocaval shunt may be predisposed to diffuse alveolar damage by 3-methylindole produced in the intestinal tract.
650 $aCaprino
650 $aDoença
653 $aSistema respiratorio
700 1 $aCARLSON, J. R.
700 1 $aBRAY, T. M.
700 1 $aBRADLEY, B. J.
773 $tAmerican Journal of Pathology$gv. 87, n. 3, p. 647-666, Jun. 1977.
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