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Registros recuperados : 78 | |
21. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Co-expression network analysis identifies genes associated with iron content in bovine muscle. In: WORKSHOP ON OMICS STRATEGIES APPLIED TO LIVESTOCK SCIENCE, 1., 2017, Piracicaba, SP. Proceedings... São Carlos, SP: Embrapa Pecuária Sudeste, 2017. p. 19. (Embrapa Pecuária Sudeste. Documentos, 125) Editores: Luiz Lehmann Coutinho, ESALQ/USP; Luciana Correia de Almeida Regitano, Embrapa Pecuária Sudeste; Gerson Barreto Mourão, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; Bárbara Silva Vignato, FZEA/USP; Mirele Daiana Poleti,... Biblioteca(s): Embrapa Pecuária Sudeste. |
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22. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Co-expression network analysis identifies genes associated with meat tenderness. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 36., 2017, Dublin. Proceedings... Dublin: University College Dublin, 2017. p. 144. Biblioteca(s): Embrapa Pecuária Sudeste. |
| ![Visualizar detalhes do registro](/consulta/web/img/visualizar.png) ![Acesso ao objeto digital](/consulta/web/img/pdf.png) ![Imprime registro no formato completo](/consulta/web/img/print.png) |
23. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | POLETI, M. D.; SIMAS, R. C.; CESAR, A. S. M.; ANDRADE, S. C. S.; SOUZA, G. H. M. F.; CAMERON, L. C.; REGITANO, L. C. de A.; COUTINHO, L. L. Label-free MSE proteomic analysis of the bovine skeletal muscle: new approach for meat tenderness evaluation. J. Anim. Sci Vol. 94, E-Suppl. 5/J. Dairy Sci. Vol. 99, E-Suppl. 1, 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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24. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | DINIZ, W. J. da S.; BANERJEE, P.; MAZZONI, G.; COUTINHO, L. L.; CESAR, A. S. M.; AFONSO, J.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; KADARMIDEEN, H. N.; REGITANO, L. C. de A. Interplay among miR-29 family, mineral metabolism, and gene regulation in Bos indicus muscle. Molecular Genetics and Genomics, v. 295, p. 1113-1127, may. 2020. Biblioteca(s): Embrapa Pecuária Sudeste. |
| ![Visualizar detalhes do registro](/consulta/web/img/visualizar.png) ![Acesso restrito ao objeto digital](/consulta/web/img/lock.png) ![Imprime registro no formato completo](/consulta/web/img/print.png) |
25. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | DINIZ, W. J. da S.; COUTINHO, L. L.; TIZIOTO, P. C.; CESAR, A. S. M.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. Iron content affects lipogenic gene expression in the muscle of nelore beef cattle. Plos One, aug. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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26. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; PÉRTILLE, F.; LEDUR, M. C.; MOURA, A. S. A. M. T. M.; GARRICK, D. J.; COUTINHO, L. L. Integration of genome wide association studies and whole genome sequencing provides novel insights into fat deposition in chicken. Scientific Reports, v. 8, n. 16222, 2018. Biblioteca(s): Embrapa Suínos e Aves. |
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27. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MOREIRA, G. C. M.; GODOY, T. F.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; LEDUR, M. C.; GARRICK, D.; SILVA, V. H. da; CROOIJAMANS, R. P.; GROENEN, M. A. M.; COUTINHO, L. L. Integration of GWAS, CNV and sele ction signature reveals candidate genes for abdominal fat regulation in chickens. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive. Biblioteca(s): Embrapa Suínos e Aves. |
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28. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | VIGNATO, B. S.; CESAR, A. S. M.; AFONSO, J.; MOREIRA, G. C. M.; POLETI, M. D.; PETRINI, J.; GARCIA, I. S.; CLEMENTE, L. G.; MOURÃO, G. B.; REGITANO, L. C. de A.; COUTINHO, L. L. Integrative analysis between genome-wide association study and expression quantitative trait Loci reveals bovine muscle gene expression regulatory polymorphisms associated with intramuscular fat and backfat thickness. Frontiers in Genetics, v. 13, 935238, aug. 2022. 15 p. Biblioteca(s): Embrapa Pecuária Sudeste. |
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29. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OLIVEIRA, G. B.; REGITANO, L. C. de A.; CESAR, A. S. M.; REECY, J. M.; DEGAKI, K. Y.; POLETI, M. D.; FELICIO, A. M.; KOLTES, J. E.; COUTINHO, L. L. Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle. BMC Genomics, v. 19, n. 126, p. 2-16, 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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30. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | POLETI, M. D.; REGITANO, L. C. de A.; SOUSA, G. H. M. F.; CESAR, A. S. M.; SIMAS, R. C.; SILVA-VIGNATO, B.; OLIVEIRA, G. B.; ANDRADE, S. C. S.; CAMERON, L. C.; COUTINHO, L. L. Longissimus dorsi muscle label-free quantitative proteomic reveals biological mechanisms associated with intramuscular fat deposition. Journal of Proteomics, v. 179, p. 30-41, 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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31. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | POLETI, M. D.; REGITANO, L. C. de A.; SOUZA, G. H. M. F.; CESAR, A. S. M.; SIMAS, R. C.; VIGNATTO, B. S.; MONTENEGRO, H.; PÉRTILLE, F.; BALIEIRO, J. C. C.; CAMERON, L. C.; ELER, J. P.; COUTINHO, L. L. Proteome alterations associated with the oleic acid and cis-9, trans-11 conjugated linoleic acid content in bovine skeletal muscle. Journal of Proteomics, v. 222, p. 1-14, e103792, jun. 2020. Biblioteca(s): Embrapa Pecuária Sudeste. |
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32. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | CESAR, A. S. M.; REGITANO, L. C. de A.; LANNA, D. P. D.; POLETI, M. D.; KOLTES, J. E.; REECY, J. M.; FRITZ-WATERS, E.; KRAMER, L.; GARRICK, D.; MUDADU, M. de A.; TULLIO, R. R.; COUTINHO, L. L. Expression quantitative trait loci (eQTL) hotspot regions from whole genome analysis of Nellore steers. In: PLANT AND ANIMAL GENOME CONFERENCE, 24., 2016, San Diego. Anais... San Diego: PAG, 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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33. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | SOUZA, M. M.; ZERLOTINI, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; SOMAVILLA, A. L.; MOKRY, F. B.; CESAR, A. S. M.; DINIZ, W. J. S.; MUDADU, M. A.; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. A. Complex pattern of CAST allelic expression in bovine muscle tissue. In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 22., 2014, Boston, USA. Program... [Boston]: International Society for Computational Biology, 2014. Não paginado. ISMB 2014. Pôster E13. Biblioteca(s): Embrapa Agricultura Digital. |
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34. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | POLETI, M. D.; REGITANO, L. C. de A.; SOUZA, G. H. M. F.; CESAR, A. S. M.; SIMAS, R. C.; SILVA-VIGNATO, B.; OLIVEIRA, G. B.; ANDRADE, S. C. S; CAMERON, L. C.; COUTINHO, L. L. Data from proteomic analysis of bovine Longissimus dorsi muscle associated with intramuscular fat content. Data in Brief, v. 19, p. 1314-1317, 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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35. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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36. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BOSCHIERO, C.; MOREIRA, G. C. M.; GHEYAS, A.; GODOY, T. F.; GASPARIN, G.; MARIANI, P. D. S. C.; PADUAN, M.; CESAR, A. S. M.; LEDUR, M. C.; COUTINHO, L. L. Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines. BMC Genomics, v. 19, n. 83, 2018. Biblioteca(s): Embrapa Suínos e Aves. |
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37. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BUSS, C. E.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; MUDADU, M. de A.; CESAR, A. S. M.; VENTURA, R. V.; AFONSO, J.; LIMA, A. O. de; COUTINHO, L. L.; TULLIO, R. R.; REGITANO, L. C. de A. Genome-wide efficient mixed-model study for meat quality in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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38. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BUSS, C. E.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; MUDADU, M. de A.; CESAR, A. S. M.; VENTURA, R. V.; AFONSO, J.; LIMA, A. O. D.; COUTINHO, L. L.; TULLIO, R. R.; REGITANO, L. C. de A. Genome-wide efficient mixed-model study for meat quality in Nellore cattle. Journal of Animal Science, v. 94, p. 428-429, 2016. Supplement 5. Na publicação: M. A. Mudadu. Biblioteca(s): Embrapa Agricultura Digital. |
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39. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MOREIRA, G. C. M.; SALVIAN, M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; LEDUR, M. C.; GARRICK, D.; MOURÃO, G. B.; COUTINHO, L. L. Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens. BMC Genomics, v. 20, n. 669, 2019. Biblioteca(s): Embrapa Suínos e Aves. |
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40. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; TREVISOLI, P. A.; CANTAO, M. E.; LEDUR, M. C.; IBELLI, A. M. G.; MOURA, A. S. M. T.; GARRICK, D.; COUTINHO, L. L. A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. BMC Genomics, v. 19, n. 374, 2018. Biblioteca(s): Embrapa Suínos e Aves. |
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Registros recuperados : 78 | |
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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
19/02/2019 |
Data da última atualização: |
19/02/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
POLETI, M. D.; REGITANO, L. C. de A.; SOUSA, G. H. M. F.; CESAR, A. S. M.; SIMAS, R. C.; SILVA-VIGNATO, B.; OLIVEIRA, G. B.; ANDRADE, S. C. S.; CAMERON, L. C.; COUTINHO, L. L. |
Afiliação: |
Mirele D. Poleti, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Gustavo H. M. F. Souza, MS Applications and Development Laboratory Waters Corporation; Aline S. M. Cesar, USP; Rosineide C. Simas, USP; Bárbara Silva-Vignato, USP; Gabriella B. Oliveira, USP; Sónia C. S. Andrade, USP; Luiz C. Cameron, UNIRIO; Luiz Lehmann Coutinho, USP. |
Título: |
Longissimus dorsi muscle label-free quantitative proteomic reveals biological mechanisms associated with intramuscular fat deposition. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Journal of Proteomics, v. 179, p. 30-41, 2018. |
DOI: |
https://doi.org/10.1016/j.dib.2018.06.004 |
Idioma: |
Inglês |
Conteúdo: |
The pathways involved in intramuscular fat (IMF) deposition in Longissimus dorsi muscle were investigated using an integrated transcriptome-assisted label-free quantitative proteomic approach by High Definition Mass Spectrometry. We quantified 1582 proteins, of which 164 were differentially abundant proteins (DAPs, p < 0.05) between animals with high (H) and low (L) genomic estimated breeding values (GEBV) for IMF content. Ingenuity pathway analysis (IPA) revealed that these DAPs were mainly involved in glycolysis metabolism, actin cytoskeleton signaling, cell-cell adherens junction and pathways for MAPK and insulin. A comparative study between transcriptomic (mRNA) and proteomic data showed 17 differentially expressed genes corresponding to DAPs, of which three genes/proteins did not agree on the direction of the fold change between groups. Moreover, we investigated microRNAs data to explain these differences in fold change direction, being able to unravel two of the three unexpected mRNA/protein relationships. Results demonstrated that changes in protein/mRNA levels of sarcomere organization, intracellular signal transduction and regulation of actin cytoskeleton, are involved in IMF deposition. These findings provide a deeper understanding of the highly complex regulatory mechanisms involved in IMF deposition in cattle and indicate target pathways for future studies. Significance: Intramuscular fat is the amount of fat deposited inside muscle and plays an important role in human health and meat quality attributes, influencing energy metabolism of skeletal muscle, as well as, tenderness, flavor, and juiciness of beef. We performed for the first time the utilization of integrated transcriptome-assisted label-free quantitative proteomic approach using High Definition Mass Spectrometry for characterization of the changes in the proteomic profile of the Longissimus dorsi muscle associated with intramuscular fat deposition in cattle. Furthermore, we compared the muscle proteome with the muscle transcriptome (mRNA and microRNAs), obtained by RNA-sequencing, to better understand the relationship between expression of mRNAs and proteins and to unravel essential biological mechanisms involved in bovine skeletal muscle IMF deposition. MenosThe pathways involved in intramuscular fat (IMF) deposition in Longissimus dorsi muscle were investigated using an integrated transcriptome-assisted label-free quantitative proteomic approach by High Definition Mass Spectrometry. We quantified 1582 proteins, of which 164 were differentially abundant proteins (DAPs, p < 0.05) between animals with high (H) and low (L) genomic estimated breeding values (GEBV) for IMF content. Ingenuity pathway analysis (IPA) revealed that these DAPs were mainly involved in glycolysis metabolism, actin cytoskeleton signaling, cell-cell adherens junction and pathways for MAPK and insulin. A comparative study between transcriptomic (mRNA) and proteomic data showed 17 differentially expressed genes corresponding to DAPs, of which three genes/proteins did not agree on the direction of the fold change between groups. Moreover, we investigated microRNAs data to explain these differences in fold change direction, being able to unravel two of the three unexpected mRNA/protein relationships. Results demonstrated that changes in protein/mRNA levels of sarcomere organization, intracellular signal transduction and regulation of actin cytoskeleton, are involved in IMF deposition. These findings provide a deeper understanding of the highly complex regulatory mechanisms involved in IMF deposition in cattle and indicate target pathways for future studies. Significance: Intramuscular fat is the amount of fat deposited inside muscle and plays an important role in... Mostrar Tudo |
Palavras-Chave: |
Adiposidade; Gordura intramuscular; MRNA. |
Thesagro: |
Gordura Animal. |
Thesaurus NAL: |
Mass spectrometry; MicroRNA. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 03231naa a2200313 a 4500 001 2106242 005 2019-02-19 008 2018 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.dib.2018.06.004$2DOI 100 1 $aPOLETI, M. D. 245 $aLongissimus dorsi muscle label-free quantitative proteomic reveals biological mechanisms associated with intramuscular fat deposition.$h[electronic resource] 260 $c2018 520 $aThe pathways involved in intramuscular fat (IMF) deposition in Longissimus dorsi muscle were investigated using an integrated transcriptome-assisted label-free quantitative proteomic approach by High Definition Mass Spectrometry. We quantified 1582 proteins, of which 164 were differentially abundant proteins (DAPs, p < 0.05) between animals with high (H) and low (L) genomic estimated breeding values (GEBV) for IMF content. Ingenuity pathway analysis (IPA) revealed that these DAPs were mainly involved in glycolysis metabolism, actin cytoskeleton signaling, cell-cell adherens junction and pathways for MAPK and insulin. A comparative study between transcriptomic (mRNA) and proteomic data showed 17 differentially expressed genes corresponding to DAPs, of which three genes/proteins did not agree on the direction of the fold change between groups. Moreover, we investigated microRNAs data to explain these differences in fold change direction, being able to unravel two of the three unexpected mRNA/protein relationships. Results demonstrated that changes in protein/mRNA levels of sarcomere organization, intracellular signal transduction and regulation of actin cytoskeleton, are involved in IMF deposition. These findings provide a deeper understanding of the highly complex regulatory mechanisms involved in IMF deposition in cattle and indicate target pathways for future studies. Significance: Intramuscular fat is the amount of fat deposited inside muscle and plays an important role in human health and meat quality attributes, influencing energy metabolism of skeletal muscle, as well as, tenderness, flavor, and juiciness of beef. We performed for the first time the utilization of integrated transcriptome-assisted label-free quantitative proteomic approach using High Definition Mass Spectrometry for characterization of the changes in the proteomic profile of the Longissimus dorsi muscle associated with intramuscular fat deposition in cattle. Furthermore, we compared the muscle proteome with the muscle transcriptome (mRNA and microRNAs), obtained by RNA-sequencing, to better understand the relationship between expression of mRNAs and proteins and to unravel essential biological mechanisms involved in bovine skeletal muscle IMF deposition. 650 $aMass spectrometry 650 $aMicroRNA 650 $aGordura Animal 653 $aAdiposidade 653 $aGordura intramuscular 653 $aMRNA 700 1 $aREGITANO, L. C. de A. 700 1 $aSOUSA, G. H. M. F. 700 1 $aCESAR, A. S. M. 700 1 $aSIMAS, R. C. 700 1 $aSILVA-VIGNATO, B. 700 1 $aOLIVEIRA, G. B. 700 1 $aANDRADE, S. C. S. 700 1 $aCAMERON, L. C. 700 1 $aCOUTINHO, L. L. 773 $tJournal of Proteomics$gv. 179, p. 30-41, 2018.
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