Data/hora: 24/09/2024 13:02:49

Biblioteca(s): 	Embrapa Amazônia Oriental.	
Data corrente: 	20/12/2018	
Data da última atualização: 	09/01/2019	
Autoria: 	BARBOSA, M. M. C.; VICENTINI, F. A.; CASTRO-GHIZONI, C. V.; LAMEIRA, O. A.; SÁ-NAKANISHI, A. B.; BRACHT, L.; PERALTA, R. M.; NATALI, M. R. M.; BRACHT, A.; COMAR, J. F.	
Afiliação: 	Maiara Morseli Coelho Barbosa, UNIVERSIDADE DE MARINGÁ; Fernando Augusto Vicentini, UNIVERSIDADE DE MARINGÁ; Cristiane Vizioli Castro-Ghizoni, UNIVERSIDADE DE MARINGÁ; OSMAR ALVES LAMEIRA, CPATU; Anacharis Babeto Sá-Nakanishi, UNIVERSIDADE DE MARINGÁ; Lívia Bracht, UNIVERSIDADE DE MARINGÁ; Rosane Marina Peralta, UNIVERSIDADE DE MARINGÁ; Maria Raquel Marçal Natali, UNIVERSIDADE DE MARINGÁ; Adelar Bracht, UNIVERSIDADE DE MARINGÁ; Jurandir Fernando Comar, UNIVERSIDADE DE MARINGÁ.	
Título: 	Copaiba oil decreases oxidative stress and inflammation but not colon damage in rats with TNBS-induced colitis.	
Ano de publicação: 	2018	
Fonte/Imprenta: 	Endocrine, Metabolic & Immune Disorders. Drug Targets, v. 18 , n. 3 , p. 268-280, 2018.	
DOI: 	10.2174/1871530318666180215102029	
Idioma: 	Inglês	
Conteúdo: 	Background: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. Objective: The aim of this study was to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. Methods: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS). The colonic morphology was assessed by histological analysis and the oxidative stress parameters were measured in the intestinal homogenate. The liver damage markers were measured in the plasma. Control and colitic rats were orally treated either with one single dose (acute colitis) of copaiba oil (1.15 g Kg-1) or once a day during seven days (subchronic colitis). Results: The intestinal morphology was severely modified by acute and subchronic colitis, as indicated by the intramural infiltration of polymorphonuclear cells and the increased thickness of all colon layers. The levels of TBARS, protein carbonyl groups and reactive oxygen species (ROS) were increased in the intestine of colitic rats. Copaiba oil did not attenuate the inflammatory damage in acute and subchronic colitis, but it decreased the activity of myeloperoxidase, leukocyte infiltration and oxidative stress in the colon. The level of plasma bilirubin and the activity of alkaline phosphatase were both increased in treated healthy and colitic rats. Conclusion: Copaiba oil decreased oxidative stress and inflammation but did not prevent intestinal damage in the colon of colitic rats. The alterations of plasma markers of hepatic damage caused by the oil seem to be associated to its harmful action on the liver.	
Palavras-Chave: 	Copaifera reticulata; Doença inflamatória intestinal.	
Thesagro: 	Copaíba; Óleo.	
Categoria do assunto: 	F Plantas e Produtos de Origem Vegetal	
Registro original: 	Embrapa Amazônia Oriental (CPATU)	
Exemplares: 	CPATU - (55537-1) - UPC - AP - DD -  -  -  - DIS