Data/hora: 25/06/2024 07:04:12

Biblioteca(s): | Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Meio Ambiente.
Data corrente: | 05/04/2021
Data da última atualização: | 09/08/2021
Autoria: | BECARO, A. A.; OLIVEIRA, L. P. de; CASTRO, V. L. S. S. de; SIQUEIRA, M. C.; BRANDAO, H. de M.; CORREA, D. S.; FERREIRA, M. D.
Afiliação: | ALINE APARECIDA BECARO, UFSCar; LUZIA PEDROSO DE OLIVEIRA, UNIFESP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; MARIA CELIA SIQUEIRA, UFSCar; HUMBERTO DE MELLO BRANDAO, CNPGL; DANIEL SOUZA CORREA, CNPDIA; MARCOS DAVID FERREIRA, CNPDIA.
Título: | Effects of silver nanoparticles prenatal exposure on rat offspring development.
Ano de publicação: | 2021
Fonte/Imprenta: | Environmental Toxicology and Pharmacology, v. 81, article 103546, 2021.
ISSN: | 1382-6689
DOI: | https://doi.org/10.1016/j.etap.2020.103546
Idioma: | Inglês
Conteúdo: | Abstract: Abstract: Many types of nanocomposites employed in food packaging are based on silver nanoparticles (AgNP) because of their antibacterial properties, which can increase food shelf-life. As the commercialization of AgNP products has been expanding, the released of such nanoparticles in the environment has caused enormous concern, once they can pose potential risks to the environment and human beings. For instance, exposure of the maternal environment to nanomaterials during pregnancy may impact the health of the dam, fetus and offspring. In this context, here we investigated the effects of prenatal exposure of AgNP on the pregnancy outcomes of dams and postnatal development of their offspring. Pregnant Wistar rats were exposed to distinct AgNP concentrations (0, 1, 3 and 5 micrograms/kg/day) from beginning to the end of pregnancy. At parturition, newborns were observed regarding clinical signs of toxicity and survival rate. The offspring was examined by evaluating developmental endpoints. A delay in time for vaginal opening and testes descent were detected in the offspring exposed to AgNP during embryonic development. Our results indicate that prenatal exposure to AgNP can compromise neonatal rats' postnatal development, especially the reproductive features.
Palavras-Chave: | Developmental endpoints; Silver nanoparticles.
Thesagro: | Animal de Laboratório; Composto Químico; Embrião; Prenhez; Toxidez.
Thesaurus Nal: | Animal reproduction; Ecotoxicology; Nanomaterials; Nanosilver; pregnancy; rats; reproduction.
Categoria do assunto: | H Saúde e Patologia
Registro original: | Embrapa Meio Ambiente (CNPMA)

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