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| Registros recuperados : 238 | |
| 201. |  | DE NARDO, E. A. B.; SA, L. A. N.; CAPALBO, D. M. F.; MORAES, G. J.; OLIVEIRA, M. C. B.; CASTRO, V. L. S. S.; WATANABE, M. A. Protocolo avaliacao de agentes microbianos de controle de pragas para registro como biopesticidas. IV. Testes toxicopatologicos em aves, artropodos beneficos, organismos de solo e plantas. Jaguariuna: Embrapa Meio Ambiente, 1999. 67p. (Embrapa Meio Ambiente. Documentos, 12).| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 202. | | DE NARDO, E. A. B.; SÁ, L. A. N.; CAPALBO, D. M. F.; MORAES, G. J.; OLIVEIRA, M. C. B.; CASTRO, V. L. S. S.; WATANABE, M. A. Protocolo avaliação de agentes microbianos de controle de pragas para registro como biopesticidas. IV. Testes toxicopatológicos em aves, artrópodos benéficos, organismos de solo e plantas. Jaguariuna: Embrapa Meio Ambiente, 1999. 67 p. (Embrapa Meio Ambiente. Documentos, 12).| Biblioteca(s): Embrapa Gado de Leite. |
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| 205. | | DE NARDO, E. A. B.; SA, L. A. N.; CAPALBO, D. M. F.; MORAES, G. J.; OLIVEIRA, M. C. B.; CASTRO, V. L. S. S.; WATANABE, M. A. Protocolo: avaliacao de agentes microbianos de controle de pragas para registro como biopesticides: testes toxicopatológicos em aves, artrópodos benéficos, organismos de solo e plantas. Jaguariuna: Embrapa Meio Anbiente, 1999. 4 67p. (Embrapa Meio Ambiente. Documentos, 12).| Biblioteca(s): Embrapa Algodão. |
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| 206. | | MARIGO, A. L. S.; SILVA, M. S. G. M. e; JONSSON, C. M.; CASTRO, V. L. S. S. de; CARVALHO, N. C. Uso de díptera como bioindicadora em estudos ecotoxicológicos com nanopartículas. In: ENCONTRO NACIONAL SOBRE METODOLOGIAS E GESTÃO DE LABORATÓRIOS DA EMBRAPA, 19.; SIMPÓSIO SOBRE PROCEDIMENTOS ANALÍTICOS E A RASTREABILIDADE DOS RESULTADOS DA AGROPECUÁRIA, 6., 2014, Fortaleza. Unir talentos para ultrapassar fronteiras. Anais... Fortaleza: Embrapa Agroindústria Tropical, 2014. p. 33.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 207. | | PEREIRA, F. F.; FERREIRA, M. D.; JONSSON, C. M.; JESUS, K. R. de; CASTRO, V. L. S. de; CORREA, D. S. Toxicity of engineered nanostructures in aquatic environments. In: KUMAR,V.; GULERIA, P.; RANJAN, S.; DASGUPTA, N.; LICHTFOUSE, E. (ed.). Nanotoxicology and Nanoecotoxicology, v. 1, 2021. 171 - 202| Biblioteca(s): Embrapa Instrumentação. |
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| 208. | | SILVA, G. H. da; CLEMENTE, Z.; COA, F.; RODRIGUES NETO, L. L.; CASTRO, V. L. S. S. de; MARTINEZ, D. S. T.; MONTEIRO, R. T. R. TiO2-carbon nanotubes nanohybrid toxicity in Danio rerio embryo. Toxicology Letters, v. 280, Supplement 1, p. S210-S211, 2017. Abstracts of the 53rd Congress of the European Societies of Toxicology (EUROTOX), Bratislava, Slovakia, 2017.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 209. | | SILVA, G. H. da; FRANQUI, L. S.; FARIAS, M. A. de; CASTRO, V. L. S. S. de; BYRNE, H. J.; MARTINEZ, D. S.; MONTEIRO, R. T.; CASEY, A. TiO2-MWCNT nanohybrid: Cytotoxicity, protein corona formation and cellular internalisation in RTG-2 fish cell line. Aquatic Toxicology, v.257, article106434, 2023.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 210. | | JESUS-HITZSCHKY, K. R. E. de; ASSIS, O. B. G. de; CARNIEL, B. F.; MASSINI, K. C.; CASTRO, V. L. S. S. de; FRAISOLI, C.; VALOIS, M. Uma proposta metodológica para avaliação caso-a-caso dos impactos das nanotecnologias: método "Impactos-Nanotec". In: SEMINÁRIO INTERNACIONAL DE NANOTECNOLOGIA, SOCIEDADE E MEIO AMBIENTE, 7., 2010, Rio de Janeiro. Resumos... Rio de Janeiro: FIOCRUZ, 2010.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 212. | | SILVA, G. H. da; CLEMENTE, Z.; COA, F.; RODRIGUES NETO, L. L.; CARVALHO, H. W. P. de; KHAN, L. U.; CASTRO, V. L. S. S. de; MARTINEZ, D. S. T.; MONTEIRO, R. T. R. Avaliação da toxicidade do nanomaterial hibrido tio2@mwcnt em embri. In: WORKSHOP DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 9., 2017, São Carlos. Anais... São Carlos: Embrapa Instrumentação, 2017. p. 704-707.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 213. | | CÔA, F.; STRAUSS, M.; CLEMENTE, Z.; RODRIGUES NETO, L. L.; LOPES, J. R.; ALENCAR, R. S.; SOUZA FILHO, A. G.; ALVES, O. L.; CASTRO, V. L. S. S. de; BARBIERI, E.; MARTINEZ, D. S. T. Coating carbon nanotubes with humic acid using an eco-friendly mechanochemical method: Application for Cu(II) ions removal from water and aquatic ecotoxicity. Science of the Total Environment, v. 607-608, p. 1479-1486, 2017.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 214. | | VALLIM, J. H.; CLEMENTE, Z.; CASTANHA, R. F.; PEREIRA, A. do E. S.; CAMPOS, E. V. R.; ASSALIN, M. R.; MAURER-MORELLI, C. V.; FRACETO, L. F.; CASTRO, V. L. S. S. de. Chitosan nanoparticles containing the insecticide dimethoate: a new approach in the reduction of harmful ecotoxicological effects. NanoImpact, v. 27, article 100408, 2022.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 215. | | CASTRO, V. L. S. S. de; CLEMENTE, Z.; JONSSON, C. M.; SILVA, M. S. G. M. e; VALLIM, J. H.; MEDEIROS, A. M. Z. de; MARTINEZ, D. S. T. Nanoecotoxicity assessment of graphene oxide and its relationship with humic acid. Environmental Toxicology and Chemistry, v. 37, n. 7, p. 1998-2012, 2018.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 216. | | MEDEIROS, A. M. Z.; KHAN, L. U.; DELITE, F. S.; COSTA, C. A.; OSPINA, C. A.; ALVES, O. L.; CASTRO, V. L. S. S. de; MARTINEZ, D. S. T. Nanoecotoxicity of GO@AgNPs nanohybrid on zebrafish embryos: influence of natural organic matter and chorion membrane removal. In: INTERNATIONAL CONFERENCE ON HEALTH AND SAFETY ISSUES RELATED TO NANOMATERIALS FOR A SOCIALLY RESPONSIBLE APPROACH - NANOSAFE, 6., 2018, Grenoble. Book of Abstracts... Grenoble: 2018. Ref. A91883DM. p. 116.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 217. | | SILVA, G. H. da; CLEMENTE, Z.; COA, F.; RODRIGUES NETO, L. L.; KHAN, L. U.; CARVALHO, H. W. P.; CASTRO, V. L. S. S. de; MARTINEZ, D. S. T.; MONTEIRO, R. T. R. Nanoecotoxicity and uptake of TiO2@MWCNT hybrid material on Danio rerio embryos. In: BRAZILIAN MRS MEETING, 16., 2017, Gramado. Proceedings... Gramado: Sociedade Brasileira de Pesquisa em Materiais, 2017. Ref. Q.OR3.11. p. 384.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 218. | | PESSOA, M. C. P. Y.; GHINI, R.; MARQUES, J. F.; SKORUPA, L. A.; BRANDÃO, M. S. B.; CASTRO, V. L. S. S. de; SAITO, M. L.; BETTIOL, W.; FERRAZ, J. M. G. Modelo conceitual de indicadores de sustentabilidade para a microbacia do Córrego Taquara Branca, Sumaré, SP. In: MARQUES, J. F.; SKORUPA, L. A.; FERRAZ, J. M. G. (Ed.). Indicadores de sustentabilidade em agroecossistemas. Jaguariúna: Embrapa Meio Ambiente, 2003. 281 p. Parte II, cap.2, p. 109-113.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 219. | | KITAMURA, P. C.; SILVEIRA, M. A.; FERRAZ, J. M. G.; BUSCHINELLI, C. C. de A.; CASTRO, V. L. S. S. de; CHAIM, A.; CORRALES, F. M.; MIRANDA, J. I. Pré-diagnóstico agroambiental em microbacia: propostas de intervenção. Jaguariúna: Embrapa Meio Ambiente, 1999. 40p. (Embrapa Meio Ambiente. Documentos, 1)| Biblioteca(s): Embrapa Agrobiologia; Embrapa Agroindústria Tropical; Embrapa Amapá; Embrapa Amazônia Ocidental; Embrapa Amazônia Oriental; Embrapa Clima Temperado; Embrapa Florestas; Embrapa Meio Ambiente; Embrapa Meio Norte / UEP-Parnaíba; Embrapa Meio-Norte; Embrapa Pantanal; Embrapa Roraima; Embrapa Semiárido; Embrapa Soja; Embrapa Solos; Embrapa Suínos e Aves; Embrapa Tabuleiros Costeiros; Embrapa Unidades Centrais; Embrapa Uva e Vinho. MenosEmbrapa Agrobiologia; Embrapa Agroindústria Tropical; Embrapa Amapá; Embrapa Amazônia Ocidental; Embrapa Amazônia Oriental; Embrapa Clima Temperado; Embrapa Florestas; Embrapa Meio Ambiente; Embrapa Meio Norte / UEP-Parnaíba; Embrapa Meio-Norte... Mostrar Todas |
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| 220. | | KITAMURA, P. C.; SILVEIRA, M. A.; FERRAZ, J. M. G.; BUSCHINELLI, C. C. de A.; CASTRO, V. L. S. S. de; CHAIM, A.; CORRALES, F. M.; MIRANDA, J. I. Pré-diagnóstico agroambiental em microbacia: propostas de intervenção. Jaguariúna: Embrapa Meio Ambiente, 1999. 40p. (Embrapa Meio Ambiente. Documentos, 1)| Biblioteca(s): Embrapa Territorial. |
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| Registros recuperados : 238 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
19/08/2021 |
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Data da última atualização: |
28/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
LUIS, A. I. S.; CAMPOS, E. V. R.; OLIVEIRA, J. L. de; VALLIM, J. H.; PROENÇA, P. L. de F.; CASTANHA, R. F.; CASTRO, V. L. S. S. de; FRACETO, L. F. |
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Afiliação: |
ANGÉLICA IRASEMA SIBAJA LUIS, ICTS-UNESP; ESTEFÂNIA VANGELIE RAMOS CAMPOS, UFABC; JHONES LUIZ DE OLIVEIRA, ICTS-UNESP; JOSE HENRIQUE VALLIM, CNPMA; PATRÍCIA LUIZA DE FREITAS PROENÇA, ICTS-UNESP; RODRIGO FERNANDES CASTANHA, CNPMA; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; LEONARDO FERNANDES FRACETO, ICTS-UNESP. |
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Título: |
Ecotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Journal of Nanobiotechnology, v. 19, n. 1, article 163, 2021. |
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Páginas: |
p. 1-22. |
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ISSN: |
1477-3155 |
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DOI: |
https://doi.org/10.1186/s12951-021-00910-8 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Background: Ascorbic acid (AA) is a micronutrient essential for the mechanisms of reproduction, growth, and defense in fish. However, the biosynthesis of this micronutrient does not occur in fish, so it must be supplied with food. A difficulty is that plain AA is unstable, due to the effects of light, high temperature, and oxygen, among others. The use of nanoencapsulation may provide protection and preserve the physicochemical characteristics of AA for extended periods of time, decreasing losses due to environmental factors. Method: This study evaluated the protective effect of nanoencapsulation in polymeric nanoparticles (chitosan and polycaprolactone) against AA degradation. Evaluation was made of the physicochemical stability of the nanoformulations over time, as well as the toxicological effects in zebrafish (Danio rerio), considering behavior, development, and enzymatic activity. For the statistical tests, ANOVA (two-way, significance of p < 0.05) was used. Results: Both nanoparticle formulations showed high encapsulation efficiency and good physicochemical stability during 90 days. Chitosan (CS) and polycaprolactone (PCL) nanoparticles loaded with AA had mean diameters of 314 and 303 nm and polydispersity indexes of 0.36 and 0.28, respectively. Both nanosystems provided protection against degradation of AA exposed to an oxidizing agent, compared to plain AA. Total degradation of AA was observed after 7, 20, and 480 min for plain AA, the CS nanoparticle formulation, and the PCL nanoparticle formulation, respectively. For zebrafish larvae, the LC50 values were 330.7, 57.4, and 179.6 mg/L for plain AA, the CS nanoparticle formulation, and the PCL nanoparticle formulation, respectively. In toxicity assays using AA at a concentration of 50 mg/L, both types of nanoparticles loaded with AA showed lower toxicity towards the development of the zebrafish, compared to plain AA at the same concentration. Although decreased activity of the enzyme acetylcholinesterase (AChE) did not affect the swimming behavior of zebrafish larvae in the groups evaluated, it may have been associated with the observed morphometric changes, such as curvature of the tail. Conclusions: This study showed that the use of nanosystems is promising for fish nutritional supplementation in aquaculture. In particular, PCL nanoparticles loaded with AA seemed to be most promising, due to higher protection against AA degradation, as well as lower toxicity to zebrafish, compared to the chitosan nanoparticles. The use of nanotechnology opens new perspectives for aquaculture, enabling the reduction of feed nutrient losses, leading to faster fish growth and improved sustainability of this activity. MenosAbstract: Background: Ascorbic acid (AA) is a micronutrient essential for the mechanisms of reproduction, growth, and defense in fish. However, the biosynthesis of this micronutrient does not occur in fish, so it must be supplied with food. A difficulty is that plain AA is unstable, due to the effects of light, high temperature, and oxygen, among others. The use of nanoencapsulation may provide protection and preserve the physicochemical characteristics of AA for extended periods of time, decreasing losses due to environmental factors. Method: This study evaluated the protective effect of nanoencapsulation in polymeric nanoparticles (chitosan and polycaprolactone) against AA degradation. Evaluation was made of the physicochemical stability of the nanoformulations over time, as well as the toxicological effects in zebrafish (Danio rerio), considering behavior, development, and enzymatic activity. For the statistical tests, ANOVA (two-way, significance of p < 0.05) was used. Results: Both nanoparticle formulations showed high encapsulation efficiency and good physicochemical stability during 90 days. Chitosan (CS) and polycaprolactone (PCL) nanoparticles loaded with AA had mean diameters of 314 and 303 nm and polydispersity indexes of 0.36 and 0.28, respectively. Both nanosystems provided protection against degradation of AA exposed to an oxidizing agent, compared to plain AA. Total degradation of AA was observed after 7, 20, and 480 min for plain AA, the CS nanoparticle formu... Mostrar Tudo |
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Palavras-Chave: |
Nanoencapsulação; Nanopartículas de quitosana; Polycaprolactone nanoparticles; Zebrafish. |
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Thesagro: |
Aquicultura; Peixe de Água Doce; Toxidez; Vitamina C. |
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Thesaurus NAL: |
Ascorbic acid; Chitosan; Danio rerio; Nanoparticles; Toxicity; Vitamin supplements. |
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Categoria do assunto: |
W Química e Física |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/225347/1/Vallim-Ecotoxicity-evaluation-2021.pdf
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Marc: |
LEADER 03930naa a2200409 a 4500
001 2133729
005 2021-12-28
008 2021 bl uuuu u00u1 u #d
022 $a1477-3155
024 7 $ahttps://doi.org/10.1186/s12951-021-00910-8$2DOI
100 1 $aLUIS, A. I. S.
245 $aEcotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture.$h[electronic resource]
260 $c2021
300 $ap. 1-22.
520 $aAbstract: Background: Ascorbic acid (AA) is a micronutrient essential for the mechanisms of reproduction, growth, and defense in fish. However, the biosynthesis of this micronutrient does not occur in fish, so it must be supplied with food. A difficulty is that plain AA is unstable, due to the effects of light, high temperature, and oxygen, among others. The use of nanoencapsulation may provide protection and preserve the physicochemical characteristics of AA for extended periods of time, decreasing losses due to environmental factors. Method: This study evaluated the protective effect of nanoencapsulation in polymeric nanoparticles (chitosan and polycaprolactone) against AA degradation. Evaluation was made of the physicochemical stability of the nanoformulations over time, as well as the toxicological effects in zebrafish (Danio rerio), considering behavior, development, and enzymatic activity. For the statistical tests, ANOVA (two-way, significance of p < 0.05) was used. Results: Both nanoparticle formulations showed high encapsulation efficiency and good physicochemical stability during 90 days. Chitosan (CS) and polycaprolactone (PCL) nanoparticles loaded with AA had mean diameters of 314 and 303 nm and polydispersity indexes of 0.36 and 0.28, respectively. Both nanosystems provided protection against degradation of AA exposed to an oxidizing agent, compared to plain AA. Total degradation of AA was observed after 7, 20, and 480 min for plain AA, the CS nanoparticle formulation, and the PCL nanoparticle formulation, respectively. For zebrafish larvae, the LC50 values were 330.7, 57.4, and 179.6 mg/L for plain AA, the CS nanoparticle formulation, and the PCL nanoparticle formulation, respectively. In toxicity assays using AA at a concentration of 50 mg/L, both types of nanoparticles loaded with AA showed lower toxicity towards the development of the zebrafish, compared to plain AA at the same concentration. Although decreased activity of the enzyme acetylcholinesterase (AChE) did not affect the swimming behavior of zebrafish larvae in the groups evaluated, it may have been associated with the observed morphometric changes, such as curvature of the tail. Conclusions: This study showed that the use of nanosystems is promising for fish nutritional supplementation in aquaculture. In particular, PCL nanoparticles loaded with AA seemed to be most promising, due to higher protection against AA degradation, as well as lower toxicity to zebrafish, compared to the chitosan nanoparticles. The use of nanotechnology opens new perspectives for aquaculture, enabling the reduction of feed nutrient losses, leading to faster fish growth and improved sustainability of this activity.
650 $aAscorbic acid
650 $aChitosan
650 $aDanio rerio
650 $aNanoparticles
650 $aToxicity
650 $aVitamin supplements
650 $aAquicultura
650 $aPeixe de Água Doce
650 $aToxidez
650 $aVitamina C
653 $aNanoencapsulação
653 $aNanopartículas de quitosana
653 $aPolycaprolactone nanoparticles
653 $aZebrafish
700 1 $aCAMPOS, E. V. R.
700 1 $aOLIVEIRA, J. L. de
700 1 $aVALLIM, J. H.
700 1 $aPROENÇA, P. L. de F.
700 1 $aCASTANHA, R. F.
700 1 $aCASTRO, V. L. S. S. de
700 1 $aFRACETO, L. F.
773 $tJournal of Nanobiotechnology$gv. 19, n. 1, article 163, 2021.
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