Data/hora: 25/09/2024 19:35:14

Biblioteca(s): 	Embrapa Agroindústria Tropical; Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Pecuária Sudeste.	
Data corrente: 	25/01/2024	
Data da última atualização: 	11/04/2024	
Autoria: 	ANHOLETO, L. A.; BRANCAGLION, G. A.; SANTOS, D. M. DOS; KAPRITCHKOFF, R. T. I.; CASTRO, K. N. de C.; CANUTO, K. M.; RODRIGUES, R. A. F.; CORREA, D. S.; CHAGAS, A. C. de S.; PASTRE, J. C.	
Afiliação: 	LUIS ADRIANO ANHOLETO; GUILHERME ANDRADE BRANCAGLION, UNIVERSIDADE DE CAMPINAS; DANILO MARTINS DOS SANTOS; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE DE SÃO PAULO; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; RODNEY ALEXANDRE FERREIRA RODRIGUES, UNIVERSIDADE DE CAMPINAS; DANIEL SOUZA CORREA, CNPDIA; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; JULIO CEZAR PASTRE, UNIVERSIDADE DE CAMPINAS.	
Título: 	Acaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance.	
Ano de publicação: 	2024	
Fonte/Imprenta: 	Veterinary Parasitology, v. 327, Apr. 2024, 110137.	
Páginas: 	9 p.	
DOI: 	10.1016/j.vetpar.2024.110137	
Idioma: 	Inglês	
Conteúdo: 	The ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly.	
Palavras-Chave: 	Acmella oleracea; Bovine parasite sadness; Brazilian Spotted Fever; Cattle tick; Control; Nanoformulation; Spilanthol.	
Thesagro: 	Bovino; Carrapato.	
Thesaurus Nal: 	Rickettsia rickettsii.	
Categoria do assunto: 	H Saúde e Patologia	
Registro original: 	Embrapa Agroindústria Tropical (CNPAT)	
Exemplares: 	CPPSE - (26336-1) - UPC - AP - DD - PROCI-2024.00007 - ANH - 2024.00049 - DIS
CNPAT - (17207-1) - UPC - AP - DD -  -  -  - DIS
CNPGL - (26271-1) - UPC - AP - DD -  -  -  - DIS
CNPDIA - (18388-1) - UPC - AP - DD - PROCI.24/18 -  - 2024/18 - DIS