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| 25. |  | MATSUOKA, K.; BRUNE, A.; ANSANI, C. V.; CARVALHO, M. G. de. Possibilidade do envolvimento de organismo tipo micoplasma em Melia azadarach, no Paraguai. Revista Arvore, Vicosa, v.10, n.2, p.202-206, jul./dez. 1986.| Biblioteca(s): Embrapa Florestas. |
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| 35. | | GUEDES, A. M. M.; ANTONIASSI, R.; GALDEANO, M. C.; GRIMALDI, R.; CARVALHO, M. G. DE; WILHELM, A. E. Physical and chemical characterization of interesterified Brazilian Pequi oil. In: AOCS ANNUAL MEETING & EXPO, 107., 2016, Salt Lake City, Utah. Experience the science and business dynamics driving the global fats and oils industries: abstracts. Urbana: AOCS, 2016. p. 15| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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| 37. | | FERNANDES, J. J.; FONTES, E. P. B.; BROMMOSCHENKEL, S. H. CARVALHO, M. G.; ZAMBOLIM, E. M.; ZERBINI, F. M. Molecular cloning and charactezation of TGV-ub, Begomovirus isolated from tomatões at "Triâgulo Mineiro", Brazil. Virus Reviews & Research, Florianópolis, v. 5, n. 2, p. 193, 2000. Suplemento 1. Resumo. Trabalho apresentado no 11º National Meeting of Virology,São Lourenço, 2000.| Biblioteca(s): Embrapa Hortaliças. |
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| 38. | | FERNANDES, J. J.; FONTES, E. P. B.; BROMMONSCHENKEL, S. H.; CARVALHO, M. G.; ZAMBOLIM, E. M.; ZERBINI, F. M. Molecular clonning and sequencing of Tomato rugose mosaic virus (TRMV), a geminivirus isolated form tomatoes at triangulo mineiro Brazil. Fitopatologia Brasileira, Brasilia, v.25, p.440, ago. 2000. Suplemento. Resumo.| Biblioteca(s): Embrapa Hortaliças. |
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| 39. | | SILVA, D. M.; FERREIRA-AGUERO, M. A.; CARVALHO, M. G.; DUTRA, V.; NEVES, P. M. O. J.; BUENO, A. F. Seletividade de Metarhizium anisopliae à Telenomus podisi (Hymenoptera: Scelionidae). In: SIMPÓSIO DE CONTROLE BIOLÓGICO, 12., 2011, São Paulo. Mudanças climáticas e sustentabilidade: quebra de paradigmas: anais. São Paulo: Sociedade Entomológica do Brasil, 2011. PT.03.24. 1 CD-ROM. SICONBIOL 2011.| Biblioteca(s): Embrapa Soja. |
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| 40. | | CARVALHO, M. G. de; OLIVEIRA, D. R. de; LEITÃO, G. G.; LOPES, D.; BIZZO, H. R.; ALVIANO, C. S.; ALVIANO, D. S.; LEITÃO, S. G. Antimicrobial activity of Lippia lacunosa and Lippia rotundifolia essential oils. In: INTERNATIONAL SYMPOSIUM ON ESSENTIAL OILS, 37., 2006, Grasse. Program & book of abstracts. [S.l.: s.n.], 2006. p. 74. Ref. P-21.| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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Registro Completo
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
30/08/2017 |
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Data da última atualização: |
22/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
FIDELIS, Q. C.; CASTRO, R. N.; GUILHON, G. M. S. P.; RODRIGUES, S. T.; SALLES, C. M. C. de; SALLES, J. B. de; CARVALHO, M. G. de. |
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Afiliação: |
Queli C. Fidelis, Universidade Federal Rural do Rio de Janeiro; Rosane N. Castro, Universidade Federal Rural do Rio de Janeiro; Giselle M. S. P. Guilhon, UFPA; SILVANE TAVARES RODRIGUES, CPATU; Cristiane M. C. de Salles, Universidade Federal Rural do Rio de Janeiro; João B. de Salles, UEZO; Mario G. de Carvalho, Universidade Federal Rural do Rio de Janeiro. |
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Título: |
Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Molecules, v. 17, n. 7, p. 7989-8000, 2012. |
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Idioma: |
Inglês |
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Conteúdo: |
The chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents. MenosThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75%... Mostrar Tudo |
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Palavras-Chave: |
Agentes quimiopreventivos; Biflavonoides; Isoflavonas. |
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Categoria do assunto: |
W Química e Física |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/163259/1/molecules-17-07989.pdf
|
|
Marc: |
LEADER 02407naa a2200229 a 4500
001 2074725
005 2021-12-22
008 2012 bl uuuu u00u1 u #d
100 1 $aFIDELIS, Q. C.
245 $aFlavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.$h[electronic resource]
260 $c2012
520 $aThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents.
653 $aAgentes quimiopreventivos
653 $aBiflavonoides
653 $aIsoflavonas
700 1 $aCASTRO, R. N.
700 1 $aGUILHON, G. M. S. P.
700 1 $aRODRIGUES, S. T.
700 1 $aSALLES, C. M. C. de
700 1 $aSALLES, J. B. de
700 1 $aCARVALHO, M. G. de
773 $tMolecules$gv. 17, n. 7, p. 7989-8000, 2012.
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Embrapa Amazônia Oriental (CPATU) |
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