|
|
| Acesso ao texto completo restrito à biblioteca da Embrapa Recursos Genéticos e Biotecnologia. Para informações adicionais entre em contato com cenargen.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
Data corrente: |
27/02/2012 |
Data da última atualização: |
30/04/2024 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
FERREIRA, D. N. M.; ROCHA, H. M. C.; MOREIRA, G. A. M.; SANTOS, A. S. dos; ROCHA, D. A.; MENDONÇA, R. S. de. |
Afiliação: |
DENISE NAVIA MAGALHAES FERREIRA, CENARGEN; G. A. M. MOREIRA; A. S. DOS SANTOS; RENATA SANTOS DE MENDONÇA. |
Título: |
Coleção de Referência de ácaros fitófagos e de produtos armazenados da Embrapa Recursos Genéticos e Biotecnologia. |
Ano de publicação: |
2011 |
Fonte/Imprenta: |
In: SIMPÓSIO BRASILEIRO DE ACAROLOGIA, 3., 2011, Campinas. [Resumos...]. Campinas: Instituto Biológico, 2011. |
Idioma: |
Português |
Palavras-Chave: |
Coleção zoológica; Defesa fitossanitária. |
Thesagro: |
Taxonomia. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00711nam a2200193 a 4500 001 1916667 005 2024-04-30 008 2011 bl uuuu u00u1 u #d 100 1 $aFERREIRA, D. N. M. 245 $aColeção de Referência de ácaros fitófagos e de produtos armazenados da Embrapa Recursos Genéticos e Biotecnologia.$h[electronic resource] 260 $aIn: SIMPÓSIO BRASILEIRO DE ACAROLOGIA, 3., 2011, Campinas. [Resumos...]. Campinas: Instituto Biológico$c2011 650 $aTaxonomia 653 $aColeção zoológica 653 $aDefesa fitossanitária 700 1 $aROCHA, H. M. C. 700 1 $aMOREIRA, G. A. M. 700 1 $aSANTOS, A. S. dos 700 1 $aROCHA, D. A. 700 1 $aMENDONÇA, R. S. de
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
Registro Completo
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
03/05/2021 |
Data da última atualização: |
12/08/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
BRUSCADIN, J. J.; SOUZA, M. M. DE; OLIVEIRA, K. S. DE; ROCHA, M. I. P.; AFONSO, J.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; NICIURA, S. C. M.; REGITANO, L. C. de A. |
Afiliação: |
JENNIFER JESSICA BRUSCADIN, UFSCAR; MARCELA MARIA DE SOUZA, Iowa State University; KARINA SANTOS DE OLIVEIRA, UFSCAR; MARINA IBELLI PEREIRA ROCHA, UFSCAR; JULIANA AFONSO, USP ESALQ; TAINÃ FIGUEIREDO CARDOSO, FAPESP; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, USP ESALQ; SIMONE CRISTINA MEO NICIURA, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Título: |
Muscle allele-specifc expression QTLs may afect meat quality traits in Bos indicus. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Scientific Reports, v.11, p.1-14, 2021. |
DOI: |
https://doi.org/10.1038/s41598-021-86782-2 |
Idioma: |
Inglês |
Notas: |
Article number: 7321. |
Conteúdo: |
Single nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specifc expression (ASE SNPs) were previously identifed in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given that the allele-specifc expression pattern may result from cis-regulatory SNPs, called allele-specifc expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. These aseQTLs were overlapped with methylation data from reduced representation bisulfte sequencing (RRBS) obtained from 12 animals of the same population. We identifed 1134 aseQTLs associated with 126 diferent ASE SNPs. For 215 aseQTLs, one allele potentially afected the afnity of a muscle-expressed transcription factor to its binding site. 162 aseQTLs were predicted to afect 149 miRNA binding sites, from which 114 miRNAs were expressed in muscle. Also, 16 aseQTLs were methylated in our population. Integration of aseQTL with GWAS data revealed enrichment for traits such as meat tenderness, ribeye area, and intramuscular fat . To our knowledge, this is the frst report of aseQTLs identifcation in bovine muscle. Our fndings indicate that various cis-regulatory and epigenetic mechanisms can afect multiple variants to modulate the allelic expression. Some of the potential regulatory variants described here were associated with the expression pattern of genes related to interesting phenotypes for livestock. Thus, these variants might be useful for the comprehension of the genetic control of these phenotypes. MenosSingle nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specifc expression (ASE SNPs) were previously identifed in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given that the allele-specifc expression pattern may result from cis-regulatory SNPs, called allele-specifc expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. These aseQTLs were overlapped with methylation data from reduced representation bisulfte sequencing (RRBS) obtained from 12 animals of the same population. We identifed 1134 aseQTLs associated with 126 diferent ASE SNPs. For 215 aseQTLs, one allele potentially afected the afnity of a muscle-expressed transcription factor to its binding site. 162 aseQTLs were predicted to afect 149 miRNA binding sites, from which 114 miRNAs were expressed in muscle. Also, 16 aseQTLs were methylated in our population. Integration of aseQTL with GWAS data revealed enrichment for traits such as meat tenderness, ribeye area, and intramuscular fat . To our knowledge, this is the frst report of aseQTLs identifcation in bovine muscle. Our fndings indicate that various cis-regulatory and ... Mostrar Tudo |
Palavras-Chave: |
Animal biotechnology; Functional genomics; Gene regulation. |
Thesaurus NAL: |
Animal breeding; Gene expression; Genetic markers; Genetics; Genome; Genomics; Genotype. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/225126/1/Muscle-Allele-Specifc.pdf
|
Marc: |
LEADER 02915naa a2200373 a 4500 001 2131644 005 2021-08-12 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1038/s41598-021-86782-2$2DOI 100 1 $aBRUSCADIN, J. J. 245 $aMuscle allele-specifc expression QTLs may afect meat quality traits in Bos indicus.$h[electronic resource] 260 $c2021 500 $aArticle number: 7321. 520 $aSingle nucleotide polymorphisms (SNPs) located in transcript sequences showing allele-specifc expression (ASE SNPs) were previously identifed in the Longissimus thoracis muscle of a Nelore (Bos indicus) population consisting of 190 steers. Given that the allele-specifc expression pattern may result from cis-regulatory SNPs, called allele-specifc expression quantitative trait loci (aseQTLs), in this study, we searched for aseQTLs in a window of 1 Mb upstream and downstream from each ASE SNP. After this initial analysis, aiming to investigate variants with a potential regulatory role, we further screened our aseQTL data for sequence similarity with transcription factor binding sites and microRNA (miRNA) binding sites. These aseQTLs were overlapped with methylation data from reduced representation bisulfte sequencing (RRBS) obtained from 12 animals of the same population. We identifed 1134 aseQTLs associated with 126 diferent ASE SNPs. For 215 aseQTLs, one allele potentially afected the afnity of a muscle-expressed transcription factor to its binding site. 162 aseQTLs were predicted to afect 149 miRNA binding sites, from which 114 miRNAs were expressed in muscle. Also, 16 aseQTLs were methylated in our population. Integration of aseQTL with GWAS data revealed enrichment for traits such as meat tenderness, ribeye area, and intramuscular fat . To our knowledge, this is the frst report of aseQTLs identifcation in bovine muscle. Our fndings indicate that various cis-regulatory and epigenetic mechanisms can afect multiple variants to modulate the allelic expression. Some of the potential regulatory variants described here were associated with the expression pattern of genes related to interesting phenotypes for livestock. Thus, these variants might be useful for the comprehension of the genetic control of these phenotypes. 650 $aAnimal breeding 650 $aGene expression 650 $aGenetic markers 650 $aGenetics 650 $aGenome 650 $aGenomics 650 $aGenotype 653 $aAnimal biotechnology 653 $aFunctional genomics 653 $aGene regulation 700 1 $aSOUZA, M. M. DE 700 1 $aOLIVEIRA, K. S. DE 700 1 $aROCHA, M. I. P. 700 1 $aAFONSO, J. 700 1 $aCARDOSO, T. F. 700 1 $aZERLOTINI NETO, A. 700 1 $aCOUTINHO, L. L. 700 1 $aNICIURA, S. C. M. 700 1 $aREGITANO, L. C. de A. 773 $tScientific Reports$gv.11, p.1-14, 2021.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Expressão de busca inválida. Verifique!!! |
|
|