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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
29/11/1995 |
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Data da última atualização: |
05/05/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TAMBASCO, A. J.; FERRARI, I.; SCHEID, I. R.; MORES, N.; LAUS, J. E. |
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Afiliação: |
ANTONIO JUNQUEIRA TAMBASCO, CPPSE; IRIS FERRARI, UNIVERSIDADE DE BRASILIA; ISABEL REGINA SCHEID, CNPSA; NELSON MORES, CNPSA; JOSÉ EDUARDO LAUS, USP. |
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Título: |
Cytogenetic study of intersex swine. |
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Ano de publicação: |
1990 |
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Fonte/Imprenta: |
Revista Brasileira de Genética, v. 13, n. 3, p. 521-530, 1990. |
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Idioma: |
Inglês |
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Conteúdo: |
To clarify the etiology of intersexuality due to genetic factors, 33 intersex swine and 33 of their ascendants were studied karyotypically. Metaphases were obtained from peripheral blood lymphocytes and analyzed by chromosome G and C banding in addition 10 standard Giemsa staining. Two cases of chromosome anomalies were observed: an intersex presenting 38,XX/38,XY mosaicism or chimerism, and an intersex presenting a break in one chromosome of pair 9, with a karyotype identical to that of the remaining intersex animals, i.e., 38,XX. All parents had normal karyotypes, i.e., 38,XX for females and 38,XY for males. Macro- and microscopic examinations of the genitalia of 26 of the 33 intersex animals revealed that 10 were true hermaphrodites, 14 were male pseudohermaphrodites and two were morphologically normal females except for a slightly hypertrophied clitoris and a "parrot beak"-shaped vulva. |
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Palavras-Chave: |
Anomalias; Anomaly. |
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Thesagro: |
Citogenética; Suíno. |
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Thesaurus Nal: |
cytogenetics; swine. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01517naa a2200241 a 4500
001 1042778
005 2023-05-05
008 1990 bl uuuu u00u1 u #d
100 1 $aTAMBASCO, A. J.
245 $aCytogenetic study of intersex swine.$h[electronic resource]
260 $c1990
520 $aTo clarify the etiology of intersexuality due to genetic factors, 33 intersex swine and 33 of their ascendants were studied karyotypically. Metaphases were obtained from peripheral blood lymphocytes and analyzed by chromosome G and C banding in addition 10 standard Giemsa staining. Two cases of chromosome anomalies were observed: an intersex presenting 38,XX/38,XY mosaicism or chimerism, and an intersex presenting a break in one chromosome of pair 9, with a karyotype identical to that of the remaining intersex animals, i.e., 38,XX. All parents had normal karyotypes, i.e., 38,XX for females and 38,XY for males. Macro- and microscopic examinations of the genitalia of 26 of the 33 intersex animals revealed that 10 were true hermaphrodites, 14 were male pseudohermaphrodites and two were morphologically normal females except for a slightly hypertrophied clitoris and a "parrot beak"-shaped vulva.
650 $acytogenetics
650 $aswine
650 $aCitogenética
650 $aSuíno
653 $aAnomalias
653 $aAnomaly
700 1 $aFERRARI, I.
700 1 $aSCHEID, I. R.
700 1 $aMORES, N.
700 1 $aLAUS, J. E.
773 $tRevista Brasileira de Genética$gv. 13, n. 3, p. 521-530, 1990.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
09/10/2020 |
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Data da última atualização: |
09/10/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
MARCELA MARIA DE SOUZA, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; MARINA IBELLI PEREIRA ROCHA, UFSCar; JENNIFER JESSICA BRUSCADIN, UFSCar; WELLISON JARLES DA SILVA DINIZ, UFSCar; TAINÃ FIGUEIREDO CARDOSO; ALINE SILVA MELLO CESAR, ESALQ/USP; JULIANA AFONSO, UFSCar; BRUNO GABRIEL NASCIMENTO ANDRADE, UFSCar; MAURICIO DE ALVARENGA MUDADU, CNPTIA; FABIANA BARICHELLO MOKRY, UFSCar; POLYANA CRISTINE TIZIOTO, NGS Soluções Genômicas, Piracicaba; PRISCILA SILVA NEUBERN DE OLIVEIRA; SIMONE CRISTINA MEO NICIURA, CPPSE; LUIZ LEHMANN COUTINHO, ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Allele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Scientific Reports, v. 10, n. 1, p. 1-11, 2020. |
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DOI: |
https://doi.org/10.1038/S41598-020-67089-0 |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Adhemar Zerlotini. Article number: 10204. |
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Conteúdo: |
Differences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic variation, its occurrence and effects on genetic prediction of economically relevant traits are still unexplored in bovines. Furthermore, as ASE events are likely driven by cis-regulatory mutations, scanning them throughout the bovine genome represents a significant step to elucidate the mechanisms underlying gene expression regulation. To address this question in a Bos indicus population, we built the ASE profile of the skeletal muscle tissue of 190 Nelore steers, using RNA sequencing data and SNPs genotypes from the Illumina BovineHD BeadChip (770 K bp). After quality control, 820 SNPs showed at least one sample with ASE. These SNPs were widespread among all autosomal chromosomes, being 32.01% found in 3'UTR and 31.41% in coding regions. We observed a considerable variation of ASE profile among individuals, which highlighted the need for biological replicates in ASE studies. Functional analysis revealed that ASE genes play critical biological functions in the development and maintenance of muscle tissue. Additionally, some of these genes were previously reported as associated with beef production and quality traits in livestock, thus indicating a possible source of bias on genomic predictions for these traits. |
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Palavras-Chave: |
Allele-specific expression; Allelic expression; Expressão gênica; Regulação da expressão gênica. |
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Thesagro: |
Bos Indicus. |
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Thesaurus NAL: |
Gene expression regulation. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/216548/1/AP-Allele-specific-2020.pdf
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Marc: |
LEADER 02698naa a2200397 a 4500
001 2125395
005 2020-10-09
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/S41598-020-67089-0$2DOI
100 1 $aSOUZA, M. M. de
245 $aAllele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes.$h[electronic resource]
260 $c2020
500 $aNa publicação: Adhemar Zerlotini. Article number: 10204.
520 $aDifferences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic variation, its occurrence and effects on genetic prediction of economically relevant traits are still unexplored in bovines. Furthermore, as ASE events are likely driven by cis-regulatory mutations, scanning them throughout the bovine genome represents a significant step to elucidate the mechanisms underlying gene expression regulation. To address this question in a Bos indicus population, we built the ASE profile of the skeletal muscle tissue of 190 Nelore steers, using RNA sequencing data and SNPs genotypes from the Illumina BovineHD BeadChip (770 K bp). After quality control, 820 SNPs showed at least one sample with ASE. These SNPs were widespread among all autosomal chromosomes, being 32.01% found in 3'UTR and 31.41% in coding regions. We observed a considerable variation of ASE profile among individuals, which highlighted the need for biological replicates in ASE studies. Functional analysis revealed that ASE genes play critical biological functions in the development and maintenance of muscle tissue. Additionally, some of these genes were previously reported as associated with beef production and quality traits in livestock, thus indicating a possible source of bias on genomic predictions for these traits.
650 $aGene expression regulation
650 $aBos Indicus
653 $aAllele-specific expression
653 $aAllelic expression
653 $aExpressão gênica
653 $aRegulação da expressão gênica
700 1 $aZERLOTINI NETO, A.
700 1 $aROCHA, M. I. P.
700 1 $aBRUSCADIN, J. J.
700 1 $aDINIZ, W. J. da S.
700 1 $aCARDOSO, T. F.
700 1 $aCESAR, A. S. M.
700 1 $aAFONSO, J.
700 1 $aANDRADE, B. G. N.
700 1 $aMUDADU, M. de A.
700 1 $aMOKRY, F. B.
700 1 $aTIZIOTO, P. C.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aNICIURA, S. C. M.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tScientific Reports$gv. 10, n. 1, p. 1-11, 2020.
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Embrapa Agricultura Digital (CNPTIA) |
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