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Registros recuperados : 148 | |
121. | | BONASSA, G.; VENTURIN, B.; BOLSAN, A. C.; HOLLAS, C. E.; CÂNDIDO, D.; RODRIGUES, H. C.; CANTAO, M. E.; IBELLI, A. M. G.; PRÁ, M. C. de; ANTES, F. G.; KUNZ, A. Performance and microbial features of Anammox in a single-phase reactor under progressive nitrogen loading rates for wastewater treatment plants. Journal of Environmental Chemical Engineering, v. 10, n. 107028, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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122. | | JOAQUIM, L. B.; CHUD, T. C. S.; MARCHESI, J. A. P.; SAVEGNAGO, R. P.; BUZANKAS, M. E.; ZANELLA, R.; CANTAO, M. E.; PEIXOTO, J. de O.; LEDUR, M. C.; IRGANG, R.; MUNARI, D. P. Genomic structure of a crossbred landrace pig population. Plos One, v. 14, n.2, e0212266, 2019. Biblioteca(s): Embrapa Suínos e Aves. |
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123. | | PANDOLFI, J. R. C.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; KRABBE, E. L.; AVILA, V. S. de; KRAMER, B.; ZANELLA, R.; JAENISCH, F. R. F.; MORES, M. A. Z.; COUTINHO, L. L.; LEDUR, M. C. Genetic characterization of poultry gut microbiota by 16S-rRNA gene sequencing. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 28., 2015, Florianópolis. Resumos. Florianópolis: Sociedade Brasileira de Microbiologia, 2015. Biblioteca(s): Embrapa Suínos e Aves. |
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124. | | IBELLI, A. M. G.; SALMÓRIA, L. A.; TAVERNARI, F. de C.; PEIXOTO, J. de O.; MARCELINO, D. E. P.; DAL PIZZOL, M. S.; CANTAO, M. E.; LEDUR, M. C. Identificação e caracterização de variantes funcionais no transcriptoma de duodeno em poedeiras. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL ON-LINE, 14., 2021. Anais.... Chapecó: UDESC: Concórdia: Embrapa Suínos e Aves, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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125. | | CAMPOS, F. G.; IBELLI, A. M. G.; OLIVEIRA, H. C. de; CANTAO, M. E.; PEIXOTO, J. de O.; TEIXEIRA, S. A.; COSTA, K. A.; LEDUR, M. C.; GUIMARÃES, S. E. F. Manual para identificação de RNAs longos não codificantes (lncRNAs) por meio de ferramentas bioinformáticas na análise de transcriptomas. Concórdia: Embrapa Suínos e Aves, 2023. 41 p. (Embrapa Suínos e Aves. Documentos, 244). Biblioteca(s): Embrapa Suínos e Aves. |
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126. | | DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; FERNANDES, L. T.; MORES, M. A. Z.; CAMPOS, F. G.; OLIVEIRA, H. C. de; LEDUR, M. C. MicroRNAS da via de sinalização da insulina envolvidos na manifestação de white striping em frangos de corte aos 28 dias de idade. In: WORKSHOP DE CIÊNCIA, TECNOLOGIA E INOVAÇÃO, 7., 2023, Francisco Beltrão. Anais... Francisco Beltrão: UTFPR, 2023. p. 429-438. Biblioteca(s): Embrapa Suínos e Aves. |
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127. | | NOGUEIRA, V. L. R.; ROCHA, L. L.; COLARES, G. B.; ANGELIM, A. L.; NORMANDO, L. R. O.; CANTAO, M. E.; AGNEZ-LIMA, L. F.; ANDREOTE, F. D.; MELO, V. M. M. Microbiomes and potential metabolic pathways of pristine and anthropized Brazilian mangroves. Regional Studies in Marine Science, v. 2, p. 56-64, 2015. Biblioteca(s): Embrapa Suínos e Aves. |
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128. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; FERNANDES, L. T.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Molecular mechanisms involved with influenza A nanovaccine immunogenicity in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas. Biblioteca(s): Embrapa Suínos e Aves. |
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129. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; FERNANDES, L. T.; DAL PIZZOL, M. S.; DAHMER, D. R.; CAMPOS, F. G.; OLIVEIRA, H. C. de; TAVERNARI, F. de C.; CANTAO, M. E.; LEDUR, M. C. Mirna expression profile differs between chicken lines with different growth rates. In: BRAZILIAN CONGRESS OF GENETICS, 68., 2023, Ouro Preto. Paleogenomics: sequencing ancient DNA. E-book. Ribeirão Preto: Sociedade Brasileira de Genética, 2023. p. 292. Biblioteca(s): Embrapa Suínos e Aves. |
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130. | | HEBBEL, C.; QUIRINO, M.; BASSELAR, P.; IBELLI, A. M. G.; LEDUR, M. C.; MORES, M. A. Z.; ONO, R. K.; CANTAO, M. E.; PEIXOTO, J. de O.; MARQUES, M. G.; ULGUIM, R da R.; GASPERIN, B. G.; BIANCHI, I. Regiões genômicas potencialmente associadas ao anestro em leitoas. In: CONGRESSO NACIONAL, 20., 2023, Porto Alegre. Produzindo suínos para um futuro sustentável: anais. Porto Alegre: ABRAVES, 2023. Revista Acadêmica de Ciência Animal, v. 21, supl. 2, p. 177-178, 2023. Biblioteca(s): Embrapa Suínos e Aves. |
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131. | | PEIXOTO, J. de O.; SAVOLDI, I. R.; IBELLI, A. M. G.; CANTAO, M. E.; JAENISCH, F. R. F.; GIACHETTO, P. F.; SETTLES, M. L.; ZANELLA, R.; MARCHESI, J. A. P.; PANDOLFI, J. R. C.; COUTINHO, L. L.; LEDUR, M. C. Proximal femoral head transcriptome reveals novel candidate genes related to epiphysiolysis in broiler chickens. BMC Genomics, v. 20, p. 1-17, 2019. Na publicação: José Rodrigo Pandolfi. Article number: 1031. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Suínos e Aves. |
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132. | | TEIXEIRA, S. A.; IBELLI, A. M. G.; CANTAO, M. E.; OLIVEIRA, H. C. de; LEDUR, M. C.; PEIXOTO, J. de O.; MARQUES, D. B. D.; COSTA, K. A.; COUTINHO, L. L.; GUIMARÃES, S. E. F. Sex determination using RNA-sequencing analyses in early prenatal pig development. Genes, v. 10, n. 1010, 2019. Biblioteca(s): Embrapa Suínos e Aves. |
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133. | | PACCHION, R. G.; CARVALHO, F. M.; THOMPSON, C. E.; FAUSTINO, A. L. F.; NICOLINI, F.; PEREIRA, T. S.; SILVA, R. C. B.; CANTAO, M. E.; GERBER, A.; VASCONCELOS, A. T. R.; AGNEZ-LIMA, L. F. Taxonomic and functional profiles of soil samples from Atlantic Forest and caatinga biomes in northeastern Brazil MicrobiologyOpen, Brussels, v. 3, n. 3, p. 299-315, 2014. DOI: 10.1002/mbo3.169. Biblioteca(s): Embrapa Suínos e Aves. |
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134. | | SOUZA, M. R.; IBELLI, A. M. G.; SAVOLDI, I. R.; CANTAO, M. E.; PEIXOTO, J. de O.; MORES, M. A. Z.; LOPES, J. S.; COUTINHO, L. L.; LEDUR, M. C. Transcriptome analysis identifies genes involved with the development of umbilical hernias in pigs. Plos One, v. 15, n. 5, e0232542, 2020. Biblioteca(s): Embrapa Suínos e Aves. |
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135. | | IBELLI, A. M. G.; FERNANDES, L.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; OKINO, C. H.; PEIXOTO, J. de O.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Transcriptomic profiling shows the induction of humoral and cellular response-related genes in pigs following vaccination with an Influenza A nanovaccine. In: INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM, 13., 2023, Satellite Meeting. Programme & Abstracts... Kruger Park/South Africa: IVIS, 2023. p. 109. Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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136. | | QUIRINO, M.; HEBBEL, C.; IBELLI, A. M. G.; LEDUR, M. C.; MORES, M. A. Z.; ONO, R. K.; CANTAO, M. E.; PEIXOTO, J. de O.; MOREIRA, F.; MARQUES, M. G.; ULGUIM, R. da R.; GASPERIN, B. G.; BIANCHI, I. Uso de metodologias genômicas para o estudo de fatores genéticos envolvidos com o anestro em leitoas. Suinocultura Industrial, Itu, ed. 313, ano 45, n. 4, p. 16-20, 2023. Biblioteca(s): Embrapa Suínos e Aves. |
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137. | | SILVA, A. N. da; IBELLI, A. M. G.; SAVOLDI, I. R.; CANTAO, M. E.; ZANELLA, E. L.; MARQUES, M. G.; SILVA, M. V. G. B.; PEIXOTO, J. de O.; LEDUR, M. C.; LOPES, J. S.; VARGAS, J. E.; ZANELLA, R. Whole-exome sequencing indicated new candidate genes associated with unilateral cryptorchidism in pigs. Sexual Development, 9 Feb 2023. Biblioteca(s): Embrapa Gado de Leite; Embrapa Suínos e Aves. |
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138. | | MARCHESI, J. A. P.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; PANDOLFI, J. R. C.; MARCIANO, C. M. M.; ZANELLA, R.; SETTLES, M. L.; COUTINHO, L. L.; LEDUR, M. C. Whole transcriptome analysis of the pectoralis major muscle reveals molecular mechanisms involved with white striping in broiler chickens. Poultry Science, v. 98, n. 2, p. 590-601, 2019. Biblioteca(s): Embrapa Suínos e Aves. |
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139. | | GARCIA, I. S.; TEIXEIRA, S. A.; COSTA, K. A.; MARQUES, D. B. D.; RODRIGUES, G. de A.; COSTA, T. C.; GUIMARÃES, J. D.; OTTO, P. I.; SARAIVA, A.; IBELLI, A. M. G.; CANTAO, M. E.; OLIVEIRA, H. C. de; LEDUR, M. C.; PEIXOTO, J. de O.; GUIMARÃES, S. E. F. L-Arginine supplementation of gilts during early gestation modulates energy sensitive pathways in pig conceptuses. Molecular Reproduction and Development, v. 7, p. 19-34, 2020. Biblioteca(s): Embrapa Suínos e Aves. |
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140. | | ROMANO, G. de S.; LORENZETTI, W. R.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MORES, M. A. Z.; SAVOLDI, I. R.; CARMO, K. B. do; LOPES, J. S.; PEDROSA, V. B.; CANTAO, M. E.; COUTINHO, L. L.; LEDUR, M. C. The involvement of muscle-related genes in the occurrence of scrotal hernia in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive. Biblioteca(s): Embrapa Suínos e Aves. |
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Registros recuperados : 148 | |
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Registro Completo
Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Suínos e Aves. |
Data corrente: |
09/03/2023 |
Data da última atualização: |
09/03/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 3 |
Autoria: |
SILVA, A. N. da; IBELLI, A. M. G.; SAVOLDI, I. R.; CANTAO, M. E.; ZANELLA, E. L.; MARQUES, M. G.; SILVA, M. V. G. B.; PEIXOTO, J. de O.; LEDUR, M. C.; LOPES, J. S.; VARGAS, J. E.; ZANELLA, R. |
Afiliação: |
ARTHUR NERY DA SILVA, Universidade de Passo Fundo; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; IGOR RICARDO SAVOLDI, Universidade do Contestado/Concórdia; MAURICIO EGIDIO CANTAO, CNPSA; ERALDO LOURENSO ZANELLA, UNIVERSIDADE; MARIANA GROKE MARQUES, CNPSA; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; JANE DE OLIVEIRA PEIXOTO, CNPSA; MONICA CORREA LEDUR, CNPSA; JADER SILVA LOPES, BRF/Curitiba; JOSÉ EDUARDO VARGAS, Universidade Federal do Paraná; RICARDO ZANELLA, Universidade de Passo Fundo. |
Título: |
Whole-exome sequencing indicated new candidate genes associated with unilateral cryptorchidism in pigs. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Sexual Development, 9 Feb 2023. |
DOI: |
10.1159/000528360 |
Idioma: |
Inglês |
Conteúdo: |
Abstract:
Introduction: Cryptorchidism is a hereditary anomaly characterized by the incomplete descent of one or both testicles to the scrotum. One of the challenges of this anomaly is that the retained testicle maintains its endocrine function. As a consequence, cryptorchid animals produce hormone-tainted meat in comparison to castrated animals and are likely to be more aggressive. Cryptorchidism can lead to reduced animal welfare outcomes and cause economic losses. Identifying genetic markers for cryptorchidism is an essential step toward mitigating these negative outcomes and may facilitate genome manipulation to reduce the occurrence of cryptorchidism. Attempts to identify such markers have used genome-wide association studies. Using whole-exome sequencing, we aimed to identify single nucleotide polymorphisms (SNPs) in the coding regions of cryptorchid pigs and to characterize functional pathways concerning these SNPs.
Methods: DNA was extracted and sequenced from 5 healthy and 5 cryptorchid animals from the Landrace breed, using the Illumina HiSeq 2500 platform. Data were pre-processed using the SeqyClean tool and further mapped against the swine reference genome (Sus scrofa 11.1) using BWA software. GATK was used to identify polymorphisms (SNPs and InDels), which were annotated using the VEP tool. Network prediction and gene ontology enrichment analysis were conducted using the Cytoscape platform, and STRING software was used for visualization.
Results: A total of 63 SNPs were identified across the genes PIGB, CCPG1, COMMD9, LDLRAD3, TRIM44, MYLPF, SEPTIN, ZNF48, TIA1, FAIM2, KRT18, FBP1, FBP2, CTSL, DAPK1, DHX8, GPR179, DEPDC1B, ENSSSCG00000049573, ENSSSCG00000016384, ENSSSCG00000022657, ENSSSCG00000038825, and ENSSSCG00000001229. Using pathway enrichment analyses and network prospection, we have identified the following significant adjusted p value threshold of 0.001 involved with the biological function pathways of estrogen signaling, cytoskeleton organization, and the pentose phosphate pathway.
Conclusion: Our data suggest the involvement of new SNPs and genes in developing cryptorchidism in pigs. However, further studies are needed to validate our results in a larger cohort population. Variations in the GPR179 gene, with implications at the protein level, may be associated with the appearance of this anomaly in the swine. Finally, we are showing that the estrogen signaling pathway may be involved in the pathophysiological mechanisms of this congenital anomaly as previously reported in GWAS. MenosAbstract:
Introduction: Cryptorchidism is a hereditary anomaly characterized by the incomplete descent of one or both testicles to the scrotum. One of the challenges of this anomaly is that the retained testicle maintains its endocrine function. As a consequence, cryptorchid animals produce hormone-tainted meat in comparison to castrated animals and are likely to be more aggressive. Cryptorchidism can lead to reduced animal welfare outcomes and cause economic losses. Identifying genetic markers for cryptorchidism is an essential step toward mitigating these negative outcomes and may facilitate genome manipulation to reduce the occurrence of cryptorchidism. Attempts to identify such markers have used genome-wide association studies. Using whole-exome sequencing, we aimed to identify single nucleotide polymorphisms (SNPs) in the coding regions of cryptorchid pigs and to characterize functional pathways concerning these SNPs.
Methods: DNA was extracted and sequenced from 5 healthy and 5 cryptorchid animals from the Landrace breed, using the Illumina HiSeq 2500 platform. Data were pre-processed using the SeqyClean tool and further mapped against the swine reference genome (Sus scrofa 11.1) using BWA software. GATK was used to identify polymorphisms (SNPs and InDels), which were annotated using the VEP tool. Network prediction and gene ontology enrichment analysis were conducted using the Cytoscape platform, and STRING software was used for visualization.
Results: A total of 63 ... Mostrar Tudo |
Palavras-Chave: |
Criptorquidismo; Sequenciamento completo do exoma; Whole-Exome Sequencing. |
Thesagro: |
Gene Marcador; Genética Animal; Marcador Genético; Porco; Suíno. |
Thesaurus NAL: |
Cryptorchidism. |
Categoria do assunto: |
-- |
Marc: |
LEADER 03604naa a2200373 a 4500 001 2152220 005 2023-03-09 008 2023 bl uuuu u00u1 u #d 024 7 $a10.1159/000528360$2DOI 100 1 $aSILVA, A. N. da 245 $aWhole-exome sequencing indicated new candidate genes associated with unilateral cryptorchidism in pigs.$h[electronic resource] 260 $c2023 520 $aAbstract: Introduction: Cryptorchidism is a hereditary anomaly characterized by the incomplete descent of one or both testicles to the scrotum. One of the challenges of this anomaly is that the retained testicle maintains its endocrine function. As a consequence, cryptorchid animals produce hormone-tainted meat in comparison to castrated animals and are likely to be more aggressive. Cryptorchidism can lead to reduced animal welfare outcomes and cause economic losses. Identifying genetic markers for cryptorchidism is an essential step toward mitigating these negative outcomes and may facilitate genome manipulation to reduce the occurrence of cryptorchidism. Attempts to identify such markers have used genome-wide association studies. Using whole-exome sequencing, we aimed to identify single nucleotide polymorphisms (SNPs) in the coding regions of cryptorchid pigs and to characterize functional pathways concerning these SNPs. Methods: DNA was extracted and sequenced from 5 healthy and 5 cryptorchid animals from the Landrace breed, using the Illumina HiSeq 2500 platform. Data were pre-processed using the SeqyClean tool and further mapped against the swine reference genome (Sus scrofa 11.1) using BWA software. GATK was used to identify polymorphisms (SNPs and InDels), which were annotated using the VEP tool. Network prediction and gene ontology enrichment analysis were conducted using the Cytoscape platform, and STRING software was used for visualization. Results: A total of 63 SNPs were identified across the genes PIGB, CCPG1, COMMD9, LDLRAD3, TRIM44, MYLPF, SEPTIN, ZNF48, TIA1, FAIM2, KRT18, FBP1, FBP2, CTSL, DAPK1, DHX8, GPR179, DEPDC1B, ENSSSCG00000049573, ENSSSCG00000016384, ENSSSCG00000022657, ENSSSCG00000038825, and ENSSSCG00000001229. Using pathway enrichment analyses and network prospection, we have identified the following significant adjusted p value threshold of 0.001 involved with the biological function pathways of estrogen signaling, cytoskeleton organization, and the pentose phosphate pathway. Conclusion: Our data suggest the involvement of new SNPs and genes in developing cryptorchidism in pigs. However, further studies are needed to validate our results in a larger cohort population. Variations in the GPR179 gene, with implications at the protein level, may be associated with the appearance of this anomaly in the swine. Finally, we are showing that the estrogen signaling pathway may be involved in the pathophysiological mechanisms of this congenital anomaly as previously reported in GWAS. 650 $aCryptorchidism 650 $aGene Marcador 650 $aGenética Animal 650 $aMarcador Genético 650 $aPorco 650 $aSuíno 653 $aCriptorquidismo 653 $aSequenciamento completo do exoma 653 $aWhole-Exome Sequencing 700 1 $aIBELLI, A. M. G. 700 1 $aSAVOLDI, I. R. 700 1 $aCANTAO, M. E. 700 1 $aZANELLA, E. L. 700 1 $aMARQUES, M. G. 700 1 $aSILVA, M. V. G. B. 700 1 $aPEIXOTO, J. de O. 700 1 $aLEDUR, M. C. 700 1 $aLOPES, J. S. 700 1 $aVARGAS, J. E. 700 1 $aZANELLA, R. 773 $tSexual Development, 9 Feb 2023.
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