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| 2. |  | SACHETTI, C. G.; CARVALHO, R. R. de; PAUMGARTTEN, F. J.; LAMEIRA, O. A.; CALDAS, E. D. Developmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat. Food and chemical toxicology, v. 49, n. 5, p. 1080-1085, 2011.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 6. | | SACHETTI, C. G.; FASCINELI, M. L.; SAMPAIO, J. A.; LAMEIRA, O. A.; CALDAS, E. D. Avaliação da toxicidade aguda e potencial neurotóxico do óleo-resina de copaíba (Copaifera reticulata Ducke, Fabaceae). Revista Brasileira de Farmacognosia, v. 19, n. 4, p. 937-941, out./dez. 2009.| Biblioteca(s): Embrapa Amazônia Oriental. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
23/11/2011 |
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Data da última atualização: |
11/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SACHETTI, C. G.; CARVALHO, R. R. de; PAUMGARTTEN, F. J.; LAMEIRA, O. A.; CALDAS, E. D. |
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Afiliação: |
CAMILE G. SACHETTI, UNB; ROSÂNGELA R. DE CARVALHO, FUNDAÇÃO OSWALDO CRUZ; FRANCISCO J. R. PAUMGARTTEN, FUNDAÇÃO OSWALDO CRUZ; OSMAR ALVES LAMEIRA, CPATU; ELOISA D. CALDAS, UNB. |
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Título: |
Developmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Food and chemical toxicology, v. 49, n. 5, p. 1080-1085, 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
The oleoresin of the copaiba tree (Copaifera sp., Fabaceae) is traditionally used in Brazilian herbal medicine to treat a variety of illnesses and symptoms. This study, conducted according to the OECD Guideline 414, provides data on the developmental toxicity of oleoresin from C. reticulata (COPA-R) in rats. Pregnant Wistar rats (25 per dose group) were treated by gavage with COPA-R (0, 500, 1000 and 1250 mg/kg bw/day) on gestation days (GD) 6?19 and Caesarean sections performed on GD20. Implantations, living and dead fetuses and resorptions were recorded. Half of the fetuses from each litter were examined for visceral abnormalities and the remaining were cleared and stained for skeleton evaluation. COPA-R was maternally toxic (reduced food intake and weight gain) and embryotoxic (lower fetal body weight and increased occurrence of fetal skeleton variations) at the two highest doses, but did not cause embryo deaths or fetal malformations at any dose level. The study derived an oral no-observed-adverse-effectlevel (NOAEL) for maternal and developmental toxicity induced by COPA-R of 500 mg/kg bw/day. The results suggest that copaiba oleoresin does not pose a health risk to pregnant women when used according to the recommended doses (up to five drops, three times a day). |
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Palavras-Chave: |
Copaifera reticulata. |
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Thesagro: |
Arvore angiosperma; Copaiba; Planta medicinal. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01954naa a2200217 a 4500
001 1906830
005 2022-11-11
008 2011 bl uuuu u00u1 u #d
100 1 $aSACHETTI, C. G.
245 $aDevelopmental toxicity of copaiba tree (Copaifera reticulata Ducke, Fabaceae) oleoresin in rat.$h[electronic resource]
260 $c2011
520 $aThe oleoresin of the copaiba tree (Copaifera sp., Fabaceae) is traditionally used in Brazilian herbal medicine to treat a variety of illnesses and symptoms. This study, conducted according to the OECD Guideline 414, provides data on the developmental toxicity of oleoresin from C. reticulata (COPA-R) in rats. Pregnant Wistar rats (25 per dose group) were treated by gavage with COPA-R (0, 500, 1000 and 1250 mg/kg bw/day) on gestation days (GD) 6?19 and Caesarean sections performed on GD20. Implantations, living and dead fetuses and resorptions were recorded. Half of the fetuses from each litter were examined for visceral abnormalities and the remaining were cleared and stained for skeleton evaluation. COPA-R was maternally toxic (reduced food intake and weight gain) and embryotoxic (lower fetal body weight and increased occurrence of fetal skeleton variations) at the two highest doses, but did not cause embryo deaths or fetal malformations at any dose level. The study derived an oral no-observed-adverse-effectlevel (NOAEL) for maternal and developmental toxicity induced by COPA-R of 500 mg/kg bw/day. The results suggest that copaiba oleoresin does not pose a health risk to pregnant women when used according to the recommended doses (up to five drops, three times a day).
650 $aArvore angiosperma
650 $aCopaiba
650 $aPlanta medicinal
653 $aCopaifera reticulata
700 1 $aCARVALHO, R. R. de
700 1 $aPAUMGARTTEN, F. J.
700 1 $aLAMEIRA, O. A.
700 1 $aCALDAS, E. D.
773 $tFood and chemical toxicology$gv. 49, n. 5, p. 1080-1085, 2011.
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