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| Registros recuperados : 326 | |
| 301. |  | HOLANDA, D. K. R.; WURLITZER, N. J.; DIONISIO, A. P.; BARROS, A. R. C.; BRITO, E. S. de; SILVA, L. M. A. e; RIBEIRO, P. R. V.; COSTA, A. M.; SOUZA, P. H. M. DE; LIMA, F. A. V.; MOREIRA, R. DE A. Passiflora tenuifila Killip: assessment of chemical composition by ¹H NMR and UPLC-ESI-Q-TOF-MSe and its bioactive properties in a rotenone-induced rat model of Parkinson's disease. Journal of Functional Foods, Amsterdam, v. 62, artigo 103529, p. 1-9, Nov. 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 302. | | CARVALHO, D. V.; SILVA, L. M. A. e; ALVES FILHO, E. DE G.; SANTOS, F. A.; LIMA, R. P. DE; VIANA, A. F. S. C.; NUNES, P. I. G.; FONSECA, S. G. DA C.; MELO, T. S. DE; VIANA, DANIEL DE ARAÚJO; GALLÃO, M. I.; BRITO, E. S. de. Cashew apple fiber prevents high fat diet-induced obesity in mice: an NMR metabolomic evaluation. Food & Function, Cambridge, v. 10, n. 3, p. 1671-1683, mar. 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 303. | | PAIVA, J. R. DE; SOUZA, A. S. DE Q.; PEREIRA, R. de C. A.; RIBEIRO, P. R. V.; ALVES FILHO, E. G.; SILVA, L. M. A. e; ZOCOLO, G. J.; BRITO, E. S. de; ALVES, D. R.; MORAIS, S. M. DE; TAVARES, J.; PINTO, F. DAS C. L.; ANDRADE, G. M. DE; PESSOA, O. D. L.; CANUTO, K. M. Chemical composition and anticholinesterase activity of cultivated bulbs from Hippeastrum elegans, a potential tropical source of bioactive alkaloids. Phytochemistry Letters, v. 43, June, p. 27-34, 2021.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 304. | | ANDRADE, J. C.; SILVA, A. R. P. DA; SANTOS, A. T. L. DOS; FREITAS, M. A.; MATOS, Y. M. L. S. DE; BRAGA, M. F. B. M.; BEZERRA, C. F.; GONÇALO, M. I. P.; VEGA-GÓMEZ, MARIA CELESTE; ROLÓN, M. S.; CORONEL MOLAS, C. C.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M. Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart. Asian Pacific Journal of Tropical Biomedicine, Haikou, v. 9, n. 5, p. 222-226, May 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 305. | | BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F. Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022.| Biblioteca(s): Embrapa Alimentos e Territórios. |
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| 306. | | GUEDES, J. A. C.; SANTIAGO, Y. G.; LUZ, L. dos R.; SILVA, M. F. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; OLIVEIRA, V. R. de; PESSOA. C. do Ó.; CANUTO, K. M.; BRITO, E. S. de; LIMA, M. F.; ALVES, R. E.; ZAMPIERI, D.; NASCIMENTO, R. F. do; ZOCOLO, G. J. Comparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil. Phytochemistry Letters, v. 40, p. 26-36, 2020.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Semiárido. |
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| 307. | | NASCIMENTO, F. M. G. DO; TREVISAN, M. T. S.; ALVES NETO, M. L.; OWEN, R. W.; BRITO, E. S. de; SILVA, L. M. A. e; ROCHA, K. A. D.; CESAR, C. L.; CARVALHO, H. F. DE; PELEGATI, V. B.; SILVA, S. A. DA; MARQUES, S. P. D. Comparison of α and β -acid isomerization in hops and beer using HPLC, confocal microscopy, spectrofluorimetry and chemical analysis of metabolites and essential oils in flowers of different hop cultivars produced .in Brazil Food Chemistry, v. 455, 139879, 2024.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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| 308. | | GUEDES, J. A. C.; ALVES FILHO, E. G.; RODRIGUES, T. H. S.; SILVA, M. F. S.; SOUZA, F. V. D.; SILVA, L. M. A. e; ALVES, R. E.; CANUTO, K. M.; BRITO, E. S. de; PESSOA, C. O.; NASCIMENTO, R. F.; ZOCOLO, G. J. Metabolic profile and cytotoxicity of non-polar extracts of pineapple leaves and chemometric analysis of different pineapple cultivars. Industrial Crops and Products, v. 124, p. 466-474, 2018.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Mandioca e Fruticultura. |
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| 309. | | CASTRO, C. B. DE; LUZ, L. DOS R.; GUEDES, J. A. C.; PORTO, D. D.; SILVA, M. F. S.; SILVA, G. S. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; ZAMPIERI, D. DE S.; Ó, C. DO; ZOCOLO, G. J. Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva. Journal of the Brazilian Chemical Society, v. 31,n. 4, p. 775-787, 2020.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 310. | | CASTRO, C. B. DE; LUZ, L. DOS R.; GUEDES, J. A. C.; PORTO, D. D.; SILVA, M. F. S.; SILVA, G. S. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; ZAMPIERI, D. DE S.; PESSOA, C. do Ó.; ZOCOLO, G. J. Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva. Journal of the Brazilian Chemical Society, v. 31, n. p. 775-787, 2020.| Biblioteca(s): Embrapa Semiárido. |
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| 311. | | GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J. GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Semiárido. |
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| 312. | | PEDRA, N. S.; GALDINO, K. C. A.; SILVA, D. S.; RAMOS, P. T.; BONA, N. P.; SOARES, M. S. P.; AZAMBUJA, J. H.; CANUTO, K. M.; BRITO, E. S. de; RIBEIRO, P. R. V.; SOUZA, A. S. de Q.; CUNICO, W.; STEFANELLO, F. M.; SPANEVELLO, R. M.; BRAGANHOL, E. Endophytic Fungus Isolated From Achyrocline satureioides Exhibits Selective Antiglioma Activity - The Role of Sch-642305. Frontiers in Oncology, v. 8, art. 476, 2018.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 313. | | COSTA, A. R.; SILVA, J. R. de L.; PEREIRA, P. S.; BEZERRA, J. W. A.; OLIVEIRA, M. A. S. de; RIBEIRO, P. R. V.; BRITO, E. S. de; DRUMOND, M. A.; CALIXTO JÚNIOR, J. T.; KAMDEM, J. P.; DUARTE, A. E.; BARROS, L. M.; COUTINHO, H. D. M. Influence of abiotic factors on phytochemical diversity of Anacardium occidentale L. Food Bioscience, v. 49, 101911, 2022.| Biblioteca(s): Embrapa Semiárido. |
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| 314. | | COSTA, A. R.; SILVA, J. R. DE L.; OLIVEIRA, T. J. S. DE; SILVA, T. G. DA; PEREIRA, P. S.; BORBA, E. F. DE O.; BRITO, E. S. de; RIBEIRO, P. R. V.; BEZERRA, J. W. A.; CALIXTO JÚNIOR, J. T.; MENEZES, I. R. A. DE; KAMDEM, J. P.; DUARTE, A. E.; BARROS, L. M. Phytochemical profile of Anacardium occidentale L. (cashew tree) and the cytotoxic and toxicological evaluation of its bark and leaf extracts. South African Journal of Botany, [Amsterdam], v. 135, p. 355-364, Dec. 2020.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 315. | | SABINO, L. B. DE S.; GONZAGA, M. L. DA C.; OLIVEIRA, L. DE S.; DUARTE, A. S. G.; SILVA, L. M. A. e; BRITO, E. S. de; FIGUEIREDO, R. W. DE; SILVA, L. M. R. DA; SOUSA, P. H. M. DE. Polysaccharides from acerola, cashew apple, pineapple, mango and passion fruit co-products: structure, cytotoxicity and gastroprotective effects. Bioactive Carbohydrates and Dietary Fibre, [Amsterdam], v. 24, artigo 100228, 11 p., Oct. 2020.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 316. | | CUNHA, A. P.; RIBEIRO, A. C. B.; RICARDO, N. M. P. S.; OLIVEIRA, A. C.; DÁVILA, L. S. P.; CARDOSO, J. H. L.; RODRIGUES, D. C.; AZEREDO, H. M. C. de; SILVA, L. M. A. e; BRITO, E. S. de; MENDES FILHO, J.; ROCHA, T. M.; LEAL, L. K. A. M. Polysaccharides from Caesalpinia ferrea seeds - Chemical characterization and anti-diabetic effects in Wistar rats. Food Hydrocolloids, v. 65, p. 68-76, 2017.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 317. | | SOUZA, L. G. da S.; ALMEIDA, M. C. S.; LEMOS, T. L. G.; RIBEIRO, P. R. V.; BRITO, E. S. de; SILVA, V. L. M.; SILVA, A. M. S.; FILHO, R. B.; COSTA, J. G. M.; RODRIGUES, F. F. G.; BARRETO, F. S.; MORAES, M. O. de. Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes. Bioorganic & Medicinal Chemistry Letters, v. 26, n. 2, p. 435-439, 2016.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 318. | | SILVA, M. F. S.; SILVA, L. M. A. e; QUINTELA, A. L.; SANTOS, A. G. DOS; SILVA, F. A. N.; OLIVEIRA, F. DE C. E. DE; ALVES FILHO, E. DE G.; BRITO, E. S. de; CANUTO, K. M.; PESSOA, CLAUDIA DO Ó; ZOCOLO, G. J. UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites. Journal of Chromatography B, Amsterdam, v. 1120, p. 51-61, 1 July 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 319. | | ANDRADE, J. C.; SILVA, A. M. DE O. E; SANTOS, A. T. L. DOS; FREITAS, M. A.; CARNEIRO, J. N. P.; GONÇALO, M. I. P.; SOUZA, A. Z. DE; FREITAS, T. S. DE; RIBEIRO, P. R. V.; BRITO, E. S. de; BRAGA, M. F. B. M.; COUTINHO, H. D. M. UPLC-MS-ESI-QTOF characterization and evaluation of the antibacterial and modulatory antibiotic activity of Ziziphus joazeiro Mart. aqueous extracts. South African Journal of Botany, Amsterdam, v. 123, p. 105-112, July 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 320. | | OLIVEIRA, M. T. A.; ALENCAR, M. V. O. B. DE; LANDIM, V. DE P. dos A.; MOURA, G. M. M.; JOELTON IGOR OLIVEIRA DA CRUZ; SANTOS, E. A. DOS; HENRIQUE DOUGLAS MELO COUTINHO; ANDRADE, J. C.; MENEZES, I. R. A. DE; RIBEIRO, P. R. V.; BRITO, E. S. de; SOUSA, E. O. DE. UPLC-MS-QTOF analysis and antifungal activity of Cumaru (Amburana cearensis). 3 Biotech, [Cham], v. 10, n. 12, artigo 545, 17 p., Dec. 2020.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| Registros recuperados : 326 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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Data corrente: |
17/11/2023 |
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Data da última atualização: |
17/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
PINHEIRO, J. C. A.; SOUZA, C. E. S. DE; RIBEIRO, D. A.; SILVA, A. DE A.; SILVA, V. B. DA; SANTOS, A. T. L. DOS; FONSECA, V. J. A.; MACÊDO, D. G. DE; CRUZ, R. P. DA; BEZERRA, J. W. A.; MACHADO, A. J. T.; FREITAS, T. S. DE; BRITO, E. S. de; RIBEIRO, P. R. V.; COSTA, J. G. M. DA; COUTINHO, H. D. M.; KOWALSKA, G.; ROWINSKI, R.; KOWALSKI, R.; BRAGA, M. F. B. M. |
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Afiliação: |
JACQUELINE COSMO ANDRADE-PINHEIRO, Regional University of Cariri; CELESTINA ELBA SOBRAL DE SOUZA, Regional University of Cariri; DAIANY ALVES RIBEIRO, Regional University of Cariri; ANDRESSA DE ALENCAR SILVA, Regional University of Cariri; VIVIANE BEZERRA DA SILVA, Federal University of Pernambuco; ANTONIA THASSYA LUCAS DOS SANTOS, Regional University of Cariri; VICTOR JUNO ALENCAR FONSECA, Regional University of Cariri; DELMACIA GONÇALVES DE MACÊDO, Regional University of Cariri; RAFAEL PEREIRA DA CRUZ, Regional University of Cariri; JOSÉ WEVERTON ALMEIDA-BEZERRA, Regional University of Cariri; ANTONIO JÚDSON TARGINO MACHADO, Regional University of Cariri; THIAGO SAMPAIO DE FREITAS, Regional University of Cariri; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; JOSÉ GALBERTO MARTINS DA COSTA, Regional University of Cariri; HENRIQUE DOUGLAS MELO COUTINHO, Regional University of Cariri; GRAZYNA KOWALSKA, University of Life Sciences in Lublin; RAFAL ROWINSKI, University of Life Sciences in Lublin; RADOSLAW KOWALSKI, University of Life Sciences in Lublin; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, Regional University of Cariri. |
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Título: |
LC-MS analysis and antifungal activity of Turnera subulata Sm. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Plants, v. 12, n. 415, 2023. |
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Páginas: |
12 p. |
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DOI: |
10.3390/plants12020415 |
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Idioma: |
Inglês |
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Conteúdo: |
Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors. |
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Palavras-Chave: |
Antifungal; Antifúngico; Extract; Extrair; Levedura; Virulência. |
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Thesaurus NAL: |
Antifungal agents; Extracts; Virulence; Yeasts. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1158504/1/LC-MS-Analysis.pdf
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|
Marc: |
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100 1 $aPINHEIRO, J. C. A.
245 $aLC-MS analysis and antifungal activity of Turnera subulata Sm.$h[electronic resource]
260 $c2023
300 $a12 p.
520 $aFungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors.
650 $aAntifungal agents
650 $aExtracts
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700 1 $aRIBEIRO, D. A.
700 1 $aSILVA, A. DE A.
700 1 $aSILVA, V. B. DA
700 1 $aSANTOS, A. T. L. DOS
700 1 $aFONSECA, V. J. A.
700 1 $aMACÊDO, D. G. DE
700 1 $aCRUZ, R. P. DA
700 1 $aBEZERRA, J. W. A.
700 1 $aMACHADO, A. J. T.
700 1 $aFREITAS, T. S. DE
700 1 $aBRITO, E. S. de
700 1 $aRIBEIRO, P. R. V.
700 1 $aCOSTA, J. G. M. DA
700 1 $aCOUTINHO, H. D. M.
700 1 $aKOWALSKA, G.
700 1 $aROWINSKI, R.
700 1 $aKOWALSKI, R.
700 1 $aBRAGA, M. F. B. M.
773 $tPlants$gv. 12, n. 415, 2023.
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Embrapa Alimentos e Territórios (CNAT) |
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