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| Registros recuperados : 227 | |
| 41. |  | ALMEIDA, J.; LOURES, M. D. de A.; GERN, J. C.; CINELLI, D.; ONORATO, G.; BITENCOURT, I.; BRANDAO, H. de M. Determinação dos parâmetros de fragmentação da Ivermectina para sua identificação por espectrometria de massas. In: WORKSHOP DE INICIAÇÃO CIENTÍFICA DA EMBRAPA GADO DE LEITE, 25., 2021, Juiz de Fora. Anais... Juiz de Fora: Embrapa Gado de Leite, 2021. (Embrapa Gado de Leite. Documentos, 261).| Biblioteca(s): Embrapa Gado de Leite. |
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| 42. | | PASCHOALIN, R. T.; BRANDÃO, H. de M.; MOREIRA, F. M. A.; HERRMANN JUNIOR, P. S. de P. Investigação da dispersão da nanopartícula de grafite magnética em água para aplicações na agropecuária. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 6., 2012, Fortaleza. Anais... São Carlos: Embrapa Instrumentação; Fortaleza: Embrapa Agroindústria Tropical, 2012. p. 467-469. Editores: Maria Alice Martins, MOrsyleide de Freitas Rosa, Men de Sá Moreira de Souza Filho, Nicodemos Moreira dos Santos Junior, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.| Biblioteca(s): Embrapa Instrumentação. |
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| 44. | | SANTOS, E. M. dos; TAVARES, L. S.; FAYER, L.; BRANDAO, H. de M.; MUNK, M.; SANTOS, M. de O. Nanoencapsulated Lippia rotundifolia antimicrobial peptide: synthesis, characterization, antimicrobial activity, and cytotoxicity evaluations. Archives of Microbiology, v. 204, n. 3, 184, 2022.| Biblioteca(s): Embrapa Gado de Leite. |
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| 46. | | OLIVEIRA, V.; PEREIRA, M. M.; BRANDAO, H. de M.; BRANDÃO, M. A. F.; GATTAZ, W. F.; RAPOSO, N. R. B. Nanotubos de carbono aplicados às neurociências: perspectivas e desafios. Revista de Psiquiatria Clínica, v. 38, n. 5, p. 201-206, 2011.| Biblioteca(s): Embrapa Gado de Leite. |
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| 48. | | TRONCARELLI, M. Z.; LANGONI, H.; BRANDAO, H. de M.; GUIMARAES, A. S.; SILVA, S. R. da; MENOZZI, B. D. Safety of a nanopropolis formulation intended for intramammary treatment of bovine mastitis in organic dairy herds. In: SIMPÓSIO DE QUALIDADE DO LEITE, 2., 2014, Jaboticabal. Anais... Jaboticabal: UNESP, 2014. 7 p. Publicado na Revista Brasileira de Higiene e Sanidade Animal, v. 8, n. 5, Supl 1, p. 520-527, 2014.| Biblioteca(s): Embrapa Gado de Leite. |
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| 49. | | GOUVEIA, A. M. G.; SILVA, M. X.; GOUVEIA, G. C.; BRANDAO, H. de M.; MENDONCA, L. C.; GUIMARAES, A. S. Zoo-sanitary aspects of goat husbandry in Southeastern Brazil. Semina. Ciências Agrárias, v. 36, n. 1, p. 277-283, 2015.| Biblioteca(s): Embrapa Gado de Leite. |
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| 51. | | SIQUEIRA, J. T. da C.; REIS, A. C.; LOPES, J. M. L.; LADEIRA, L. O.; VICCINI, L. F.; BRANDAO, H. de M.; MUNK, M.; SOUSA, S. M. de. Chromosomal aberrations and changes in the methylation patterns of Lactuca sativa L. (Asteraceae) exposed to carbon nanotubes. Biologia, v. 78, p. 1991-2002, 2023.| Biblioteca(s): Embrapa Gado de Leite. |
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| 52. | | QUINTAO, C. C. R.; ALMEIDA, C. G. de; SOUZA, G. T.; LADEIRA, L. O.; BRANDAO, H. de M.; CAMARGO, L. S. de A.; MUNK, M. Complexação da proteína CAS9 e RNA-GUIA com nanotubos de carbono visando edição gênica em células e embriões de mamíferos. In: SIMPÓSIO NACIONAL DE NANOBIOTECNOLOGIA, 2., 2019, São Bernardo do Campo. Livro de resumos. Santo André: Universidade Federal do ABC, 2018.| Biblioteca(s): Embrapa Gado de Leite. |
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| 53. | | SOUZA, N. L. G. D.; SALLES, T. F.; BRANDAO, H. de M.; EDWARDS, H. G. M.; OLIVEIRA, L. F. C. de. Synthesis, Vibrational Spectroscopic and Thermal Properties of Oxocarbon Cross?Linked Chitosan. Journal of the Brazilian Chemical Society, v. 26, n. 6, p. 1247-1256, 2015.| Biblioteca(s): Embrapa Gado de Leite. |
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| 54. | | SOUZA, G. N. de; CARNEIRO, A. V.; STOCK, L. A.; VICENTINI, N. M.; BRANDAO, H. de M.; MOREIRA, A. A. de P.; SILVA, M. R. Simulação do custo/benefício da adoção da tecnologia social Kit Embrapa Ordenha Manual em produtores de leite de baixa escala. In: CARNEIRO, A. V.; LIMA, I. B. de; RESENDE, M. L. de; LEONEL, F. de P.; DUSI, G. A.; TORRES, D. A. R. A cadeia produtiva do leite na mesorregião Campos das Vertentes de Minas Gerais. São João Del Rei: UFSJ; Juiz de Fora: Embrapa Gado de Leite, 2011. p. 151-159.| Biblioteca(s): Embrapa Gado de Leite. |
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| 55. | | SOUZA, G. N. de; CARNEIRO, A. V.; STOCK, L. A.; VICENTINI, N. M.; BRANDAO, H. de M.; MOREIRA, A. A. DE P.; SILVA, M. R. Simulação do custo/benefício da adoção da tecnologia social kit Embrapa ordenha manual em produtores de leite de baixa renda. In: JACOOB, L. L.; MORAIS, M. L. P.; MOREIRA, M. S. de P.; ESTEVAO, P.; BERNARDO, W. F. (Ed.). Experiências e técnicas para a produção familiar de leite no Vale do Piranga. Juiz de Fora: Embrapa Gado de Leite, 2013. p. 91-98| Biblioteca(s): Embrapa Gado de Leite. |
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| 57. | | POLONINI, H. C.; BRANDAO, H. de M.; RAPOSO, N. R. B.; BRANDÃO, M. A. F.; MOUTON, L.; COUTÉ, A.; YEPREMIAN, C.; SIVRY, Y.; BRAYNER, R. Size-dependent toxicity of barium titanate to Chlorella vulgaris. In: INTERNATIONAL CONFERENCE ON SAFE PRODUCTION AND USE OF NANOMATERIALS, 4., 2014, Grenoble. Book of abstracts... Grenoble: [s.n.], 2014.| Biblioteca(s): Embrapa Gado de Leite. |
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| 58. | | GOUVEIA, A. M. G.; SILVA, M. X.; MAIA, J. M. S.; BRANDAO, H. de M.; SEYFFERT, N.; MIYOSHI, A.; AZEVEDO, V.; GUIMARAES, A. S. Technological level and epidemiological aspects of sheep husbandry in Minas Gerais, southeastern Brazil. Pesquisa Veterinária Brasileira, v. 34, n. 9, p. 865-868, 2014.| Biblioteca(s): Embrapa Gado de Leite. |
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| 59. | | PEREIRA, M. M.; ROCHA, A. da; YÉPRÉMIAN, C.; COUTÉ, A.; MOUTON, L.; RAPOSO, N. R. B.; MATTOSO, L. H. C.; BRANDÃO, H. de M.; BRAYNER, R. Impacto de nanofibras de celulose na viabilidade celular e na capacidade fotossintética da microalga Chlorella Vulgaris. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 7.; ESCOLA DE NANOTECNOLOGIA, 3., 2013, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação, 2013. p. 516-518 Editores: Maria Alice Martins, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso. CD-ROM. Editores: Maria Alice Martins, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Instrumentação. |
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| 60. | | PEREIRA, M. M.; BRANDAO, H. de M.; RAPOSO, N. R.; SERAPIÃO, R. V.; CARVALHO, B. C.; CAMARGO, L. S. de A.; LADEIRA, L. O. Gene expression and apoptosis in bovine preimplantation embryo exposed to carbon nanotubes. In: INTERNATIONAL CONFERENCE ON FOOD AND AGRICULTURE APPLICATIONS OF NANOTECHNOLOGIES, 1., 2010, São Pedro, SP. [Anais...] São Pedro: Aptor Software, 2010.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 227 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
20/04/2023 |
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Data da última atualização: |
18/07/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
PEREA, G. N. R.; PAVINATTO, A.; SCHNEIDER, R.; MUNK, M.; BRANDAO, H. de M.; CORREA, D. S. |
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Afiliação: |
Universidade de São Paulo; Universidade Federal de São Carlos; Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Electrospun nanofibers based on polyvinylpyrrolidone/chitosan and cloxacillin: investigation of morphological features, antibiotic release and antimicrobial properties. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Journal of Polymer Research, v. 30, 166, 2023. |
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DOI: |
https://doi.org/10.1007/s10965-023-03535-7 |
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Idioma: |
Inglês |
|
Conteúdo: |
Polymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides, the drug release kinetics study indicates that the nanocarrier system formed by PVP/CHI can release the antibiotics more slowly due to the chemical interactions between CHI and CLO compounds. Our results suggest that drug activity was preserved after encapsulation by electrospinning, and the diference in the inhibition zone diameter was corroborated by drug release mechanism experiments, indicating the system as a potential material to treat infections caused by S. aureus MenosPolymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides,... Mostrar Tudo |
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Palavras-Chave: |
Antibiotic release; Electrospinning; Eletrofiação; Mastite; Slow-release. |
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Thesagro: |
Antibiótico; Bovino; Doença Animal; Tratamento. |
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Categoria do assunto: |
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L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 02915naa a2200301 a 4500
001 2153293
005 2023-07-18
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s10965-023-03535-7$2DOI
100 1 $aPEREA, G. N. R.
245 $aElectrospun nanofibers based on polyvinylpyrrolidone/chitosan and cloxacillin$binvestigation of morphological features, antibiotic release and antimicrobial properties.$h[electronic resource]
260 $c2023
520 $aPolymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides, the drug release kinetics study indicates that the nanocarrier system formed by PVP/CHI can release the antibiotics more slowly due to the chemical interactions between CHI and CLO compounds. Our results suggest that drug activity was preserved after encapsulation by electrospinning, and the diference in the inhibition zone diameter was corroborated by drug release mechanism experiments, indicating the system as a potential material to treat infections caused by S. aureus
650 $aAntibiótico
650 $aBovino
650 $aDoença Animal
650 $aTratamento
653 $aAntibiotic release
653 $aElectrospinning
653 $aEletrofiação
653 $aMastite
653 $aSlow-release
700 1 $aPAVINATTO, A.
700 1 $aSCHNEIDER, R.
700 1 $aMUNK, M.
700 1 $aBRANDAO, H. de M.
700 1 $aCORREA, D. S.
773 $tJournal of Polymer Research$gv. 30, 166, 2023.
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