Data/hora: 24/09/2024 13:49:59

Biblioteca(s): 	Embrapa Gado de Leite.	
Data corrente: 	29/10/2021	
Data da última atualização: 	29/10/2021	
Autoria: 	FAYER, L.; ZANETTE, R. S. S.; SIQUEIRA, J. T. C.; OLIVEIRA, E. R.; ALMEIDA, C. G.; GERN, J. C.; SOUSA, S. M.; OLIVEIRA, L. R. C. de; BRANDAO, H. de M.; MUNK, M.	
Afiliação: 	LEONARA FAYER, Universidade Federal de juiz de Fora; RAFAELLA S. S. ZANETTE, Universidade Federal de Juiz de Fora; JULIANA T. C. SIQUEIRA, Universidade Federal de Juiz de Fora; EDUARDA R. OLIVEIRA, Universidade Federal de Juiz de Fora; CAMILA G. ALMEIDA; JULIANA CARINE GERN, CNPGL; SAULO M. SOUSA, Universidade Federal de Juiz de Fora; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora.	
Título: 	The distinct effect of titanium dioxide nanoparticles in primary and immortalized cell lines.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	Toxicology Research, v. 10, n. 3, p. 511-522, 2021.	
DOI: 	https://doi.org/10.1093/toxres/tfab040	
Idioma: 	Inglês	
Conteúdo: 	The titanium dioxide nanoparticles (NPs) have been applied to biomedical, pharmaceutical, and food additive fields. However, the effect on health and the environment are conf licting; thus, it has been reviewing several times. In this context, establishing standard robust protocols for detecting cytotoxicity and genotoxicity of nanomaterials became essential for nanotechnology development. The cell type and the intrinsic characteristics of titanium dioxide NPs can inf luence nanotoxicity. In this work, the cyto- and genotoxicity effects of standard reference material titanium dioxide NPs in primary bovine fibroblasts and immortalized Chinese hamster ovary epithelial (CHO) cells were determined and compared for the first time. Titanium dioxide NPs exposure revealed no cytotoxicity for primary bovine fibroblasts, while only higher concentrations tested (10 ?g/ml) induce genotoxic effects in this cell model. In contrast, the lower concentrations of the titanium dioxide NPs cause the cyto- and genotoxic effects in CHO cells. Therefore, our finding indicates that the CHO line was more sensitive toward the effects of titanium dioxide NPs than the primary bovine fibroblast, which should be valuable for their environmental risk assessment.	
Palavras-Chave: 	Avaliação de risco; Célula CHO; Fibroblasto; Nanomaterial; Nanotoxicidade.	
Thesagro: 	Bovino.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (25456-1) - UPC - AP - DD -  -  -  - DIS