Data/hora: 24/09/2024 06:27:36

Biblioteca(s): 	Embrapa Gado de Leite.	
Data corrente: 	03/05/2024	
Data da última atualização: 	29/05/2024	
Autoria: 	VIEIRA, J. I. G.; BRAGA, L. G.; CHU, T. C. S.; FERREIRA, P. H.; GUIMARÃES, S. E. F.; MARTINS, M. F.; PANETTO, J. C. do C.; MACHADO, M. A.; SILVA, D. B. dos S.; BONAFÉ, C. M.; MAGALHÃES, A. F. B.; SILVA, M. V. G. B.; VERARDO, L. L.	
Afiliação: 	JOÃO INÁCIO GOMES VIEIRA, UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI; LARISSA GRACIANO BRAGA, UNIVERSIDADE ESTADUAL PAULISTA; TATIANE C. S. CHU, PEAK, URUS GROUP; PABLO HENRIQUE FERREIRA, UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI; SIMONE ELIZA FACIONI GUIMARÃES, UNIVERSIDADE FEDERAL DE VIÇOSA; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; MARCO ANTONIO MACHADO, CNPGL; DANIELLY BERALDO DOS SANTOS SILVA, UNIVERSIDADE PROF. EDSON ANTÔNIO VELANO; CRISTINA MOREIRA BONAFE, UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI; ANA FABRÍCIA BRAGA MAGALHÃES, UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; LUCAS LIMA VERARDO, UNIVERSIDADE FEDERAL DOS VALES DO JEQUITINHONHA E MUCURI.	
Título: 	Resequencing of Brazilian locally adapted cattle breeds revealed variants in candidate genes and transcription factors for meat fatty acid profile.	
Ano de publicação: 	2024	
Fonte/Imprenta: 	Journal of Animal Breeding and Genetics, 2024.	
DOI: 	https://doi.org/10.1111/jbg.12869	
Idioma: 	Inglês	
Notas: 	First online.	
Conteúdo: 	The beef cattle industry has experienced a shift driven by a market demand for healthier meat, cost efficiency and environmental sustainability in recent years. Consequently, there has been a growing focus on the fatty acids content and functions of meat in cattle breeding programmes. Besides, a deeper understanding of the biological mechanisms influencing the expression of different phenotypes related to fatty acid profiles is crucial. In this study, we aimed to identify Single-Nucleotide Variants (SNV) and Insertion/Deletion (InDels) DNA variants in candidate genes related to fatty acid profiles described in genomic, transcriptomic and proteomic studies conducted in beef cattle breeds. Utilizing whole-genome re-sequencing data from Brazilian locally adapted bovine breeds, namely Caracu and Pantaneiro, we identified SNVs and InDels associated with 23,947 genes. From these, we identified 318 candidate genes related to fatty acid profiles that contain variants. Subsequently, we select only genes with SNVs and InDels in their promoter, 5' UTR and coding region. Through the gene-biological process network, approximately 19 genes were highlighted. Furthermore, considering the studied trait and a literature review, we selected the main transcription factors (TF). Functional analysis via gene-TF network allowed us to identify the 30 most likely candidate genes for meat fatty acid profile in cattle. LIPE, MFSD2A and SREBF1 genes were highlighted in networks due to their biological importance. Further dissection of these genes revealed 15 new variants found in promoter regions of Caracu and Pantaneiro sequences. The gene networks facilitated a better functional understanding of genes and TF, enabling the identification of variants potentially related to the expression of candidate genes for meat fatty acid profiles in cattle.	
Palavras-Chave: 	Pós-ômica; Sequenciamento genômico.	
Thesagro: 	Bovino; Genética Animal; Genoma.	
Thesaurus Nal: 	Genomics.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (26356-1) - UPC - AP - DD -  -  -  - DIS