Data/hora: 09/06/2024 20:50:42

Biblioteca(s): | Embrapa Unidades Centrais.
Data corrente: | 20/11/2017
Data da última atualização: | 29/12/2017
Autoria: | GALVÃO, A. B.; CARVALHO, M. B.; BATALHAO, L. G.; SILVA, J. C. B. da; BATALHÃO, M.; CARNIO, E. C.
Afiliação: | André B. Galvão, Programa de Pós-Graduação em Medicina Veterinária/DCCV/FCAV/UNESP; Marileda B. Carvalho, Programa de Pós-Graduação em Medicina Veterinária/DCCV/FCAV/UNESP; Luciane G. Batalhão, Departamento de Morfologia e Fisiologia Animal/FCAV/Unesp; JULIANA CORREA BORGES SILVA, CPAP; Marcelo Batalhão, Escola de Enfermagem de Ribeirão Preto/Universidade de São Paulo - USP; Evelin C. Carnio, Escola de Enfermagem de Ribeirão Preto/Universidade de São Paulo - USP.
Título: | Increased nitric oxide plasma concentration in dogs with naturally acquired chronic renal disease.
Ano de publicação: | 2017
Fonte/Imprenta: | Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 8, p. 847-852, ago. 2017.
Idioma: | Inglês
Notas: | Título em português: Aumento da concentração plasmática de óxido nítrico em cães com doença renal crônica naturalmente adquirida.
Conteúdo: | This study aimed to determine the amount of plasma nitric oxide in clinically stable dogs at different stages of chronic kidney disease (CKD). Five groups of dogs were studied, aged from 4 to 18, comprising of a control group composed of healthy animals (control n=17), group CKD stage 1 (DRC-1, n=12), group CKD stage 2 (CKD-2, n=10) group, CKD stages 3 (CRD-3, n=13) and Group CKD stage 4 (DRC-4, n=10). Dogs with CKD were clinically stable and received no treatment. Two blood samples were collected at 24 hours intervals (repeated measures) to obtain serum and plasma. The serum creatinine values were used to classify dogs as CG, CKD-1, CKD-2, CKD-3 and CKD-4, and were (1.02±0.02mg/dL), (1.07±0.04mg/dL), (1.81±0.03mg/dL), (3.40±0.15mg/dL) and (6.00±0.20mg/dL) respectively. The determination of nitric oxide (NO) was performed by dosing nitrate/nitrite indirectly, and used for measurement of nitrate according to the NO/ozone chemiluminescence. The data were submitted to ANOVA for nonparametric analysis(Kruskal-Wallis) (P<0.05). The concentration of plasmatic NO did not differ significantly among GC (10.81±0.51&#956;M), CKD-1 (15.49±1.97&#956;M) and CKD-2 (19.83±3.31&#956;M) groups. The plasma concentration of CKD-3 (17.02±1.73&#956;M) and CKD-4 (83.56±13.63&#956;M) was significantly higher compared ith healthy dogs. In conclusion, the NO plasma concentration can increase in dogs with CKD and become significantly higher in stage 3 and 4 dogs.
Palavras-Chave: | Azotemia; Concentração plasmática; Doença renal crônica; Hipertensão; Nitric oxide plasma concentration; Óxido nítrico.
Thesagro: | Cão; Creatinina.
Thesaurus Nal: | Creatinine; Dogs; Hypertension; proteinuria; Uremia.
Categoria do assunto: | --
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/167015/1/Increased-nitric-oxide-plasma.pdf
Registro original: | Embrapa Unidades Centrais (AI-SEDE)
Exemplares: | AI-SEDE - (61911-1) - UPE - AP - DD -  -  -  - DIS