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14. | | BOMBASSARO, G. E.; GAVA, D.; HAACH, V.; MACIAG, S. S.; SCHAEFER, R.; BASTOS, A. P. A. Acompanhamento de um surto de doença vesicular associado ao senecavirus A em suínos. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 15., 2021, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2021. p. 45-46. Biblioteca(s): Embrapa Suínos e Aves. |
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15. | | FORNER, R. A. N.; TREVISOL, I. M.; OKINO, C. H.; BRENTANO, L.; BASTOS, A. P. A. Analysis of the cell immune response of avian infectious bronchitis variants by flow cytometry. In: ANNUAL CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 42.; EXTRA SECTION OF CLINICAL IMMUNOLOGY, 5., 2017, Salvador. Mucosal immunology 2017: abstract São Paulo: SBI, 2017. Biblioteca(s): Embrapa Suínos e Aves. |
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16. | | BASTOS, A. P. A.; BARON, L. F.; TREVISOL, I. M.; IANISKI, F.; BRENTANO, L. Analysis of the cell immune response and of the renal morphological damage of Avian Infectious Bronchitis variants. In: ANNUAL CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 43.; EXTRA SECTION OF CLINICAL IMMUNOLOGY, 6., 2018, Ouro Preto. Immuno 2018: abstract book. São Paulo: SBI, 2018. Biblioteca(s): Embrapa Suínos e Aves. |
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17. | | FONSECA, F. M. da; BARON, L. F.; TREVISOL, I. M.; BASTOS, A. P. A.; BRENTANO, L. Estudo de pré-formulação de nanovacina para tratamento da doença de newcastle em aves. In: WORKSHOP DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 9., 2017, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação, 2017. p. 235-238. Biblioteca(s): Embrapa Suínos e Aves. |
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18. | | BARON, L. F.; BASTOS, A. P. A.; BELLAVER, F. A. V.; FONSECA, F. M. da. Desenvolvimento, caracterização e avaliação da viabilidade celular de nanopartículas poliméricas contendo resveratrol. In: CONGRESSO INTERNACIONAL DE NANOTECNOLOGIA, 3.; SIMPÓSIO SOBRE NANOBIOTECNOLOGIA E SUAS APLICAÇÕES, 6., 2018, Novo Hamburgo. Trabalhos. Novo Hamburgo: Feevale, 2018. CINA 2018. Biblioteca(s): Embrapa Suínos e Aves. |
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Registros recuperados : 57 | |
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Registro Completo
Biblioteca(s): |
Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
Data corrente: |
11/09/2023 |
Data da última atualização: |
11/09/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 3 |
Autoria: |
HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. |
Afiliação: |
VANESSA HAACH, Universidade Federal do Rio Grande do Sul; ANA PAULA ALMEIDA BASTOS, CNPSA; DANIELLE GAVA, CNPSA; FRANCISCO NOE DA FONSECA, GEM; MARCOS ANTONIO ZANELLA MORES, CNPSA; ARLEI COLDEBELLA, CNPSA; ANA CLÁUDIA FRANCO, Universidade Federal do Rio Grande do Sul; REJANE SCHAEFER, CNPSA. |
Título: |
A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Virology Journal, v. 20, article number 181, 2023. |
DOI: |
https://doi.org/10.1186/s12985-023-02153-5 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. |
Palavras-Chave: |
Cellular immunity; Virosomal vaccine. |
Thesagro: |
Imunidade; Suíno; Vacina. |
Thesaurus NAL: |
Humoral immunity; Influenza A virus; Swine. |
Categoria do assunto: |
-- L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156557/1/final10093.pdf
|
Marc: |
LEADER 02316naa a2200313 a 4500 001 2156557 005 2023-09-11 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s12985-023-02153-5$2DOI 100 1 $aHAACH, V. 245 $aA polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs.$h[electronic resource] 260 $c2023 520 $aAbstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. 650 $aHumoral immunity 650 $aInfluenza A virus 650 $aSwine 650 $aImunidade 650 $aSuíno 650 $aVacina 653 $aCellular immunity 653 $aVirosomal vaccine 700 1 $aBASTOS, A. P. A. 700 1 $aGAVA, D. 700 1 $aFONSECA, F. M. da 700 1 $aMORES, M. A. Z. 700 1 $aCOLDEBELLA, A. 700 1 $aFRANCO, A. C. 700 1 $aSCHAEFER, R. 773 $tVirology Journal$gv. 20, article number 181, 2023.
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Embrapa Suínos e Aves (CNPSA) |
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