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| Registros recuperados : 57 | |
| 41. |  | MACIAG, S. S.; VOLPATO, F.; BOMBASSARO, G. E.; FORNER, R. A. N.; OLIVEIRA, K. P. V.; BOVOLATO, A. L.; LOPES, L.; BASTOS, A. P. A. Effects of freezing storage on the stability of maternal cellular and humoral immune components in porcine colostrum. Veterinary Immunology and Immunopathology, v. 254, 110520, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 42. | | TREVISOL, I. M.; MATTOS, G. L. M.; OKINO, C. H.; BRENTANO, L.; COLDEBELLA, A.; BARON, L. F.; BASTOS, A. P. A. Análise da resposta imune celular induzidas por desafio com amostras clássicas e variante de vírus da bronquite infecciosa aviária. CONFERÊNCIA FACTA-WPSA BRASIL, 2018, Campinas, SP. Avicultura 4.0: otimização dos processos de produção avícola. Campinas: FACTA, 2018. Prêmio Lamas 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 43. | | SOUZA, A. P.; BOMBASSARO, G. E.; FONSECA, F. M. da; LOPES, L. dos S.; MACIAG, S. S.; BELLAVER, F. A. V.; BASTOS, A. P. A. A comparative evaluation of methods for estimating the colostrum quality in sows. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 73, n. 5, p. 1047-1057, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 44. | | MACIAG, S. S.; BELLAVER, F. A. V.; FONSECA, F. M. da; BOMBASSARO, G. E.; GAVA, D.; LOPES, L. dos S.; BASTOS, A. P. A. Comparison of cell viability in fresh and frozen porcine colostrums. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2020, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS, 2020. p. 561.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 45. | | BOMBASSARO, G. E.; BELLAVER, F. A. V.; FONSECA, F. M. da; MACIAG, S. S.; GAVA, D.; LOPES, L. dos S.; BASTOS, A. P. A. Comparison of immune cells of colostrum from gilts and sows. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2020, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS, 2020. p. 562.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 46. | | FEDDERN, V.; BERNASCONI, N. J.; BOVOLATO, A. L. de C.; OLIVEIRA, K. P. V. de; TAVERNARI, F. de C.; GRESSLER, V.; BASTOS, A. P. A. Jornada de Carne Cultivada: uma visão sistêmica sobre terminologias, aspectos legais, nutricionais, considerações sobre consumidor e mercado potencial, métodos e meios de cultivo. Concórdia: Embrapa Suínos e Aves, 2022. 35 p. (Embrapa Suínos e Aves. Documentos, 237).| Biblioteca(s): Embrapa Suínos e Aves. |
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| 47. | | MACIAG, S. S.; BELLAVER, F. A. V.; BOMBASSARO, G. E.; HAACH, V.; MORES, M. A. Z.; BARON, L. F.; COLDEBELLA, A.; BASTOS, A. P. A. On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets. Scientific Reports, v. 12, n. 15630, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 48. | | SILVA, M. C. da; SCHAEFER, R.; GAVA, D.; SOUZA, C. K. de; VAZ JUNIOR, I. da; BASTOS, A. P. A.; VENANCIO, E. J. Production and application of anti-nucleoprotein IgY antibodies for influenza A virus detection in swine. Journal of Immunological Methods, v. 461, p. 100-105, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 49. | | HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. Virology Journal, v. 20, article number 181, 2023.| Biblioteca(s): Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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| 50. | | DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; CAMPOS, F. G.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; FERNANDES, L. T.; TAVERNARI, F. de C.; MORES, M. A. Z.; BASTOS, A. P. A.; LEDUR, M. C. Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis. BMC Genomics, v. 25, n. 104, p. 1-14, 2024.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 51. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; FERNANDES, L. T.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Molecular mechanisms involved with influenza A nanovaccine immunogenicity in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 52. | | SANTOS, M. S. C. dos; GOUVÊA, A. L.; MOURA, L. D. de; PATERNO, L. G.; SOUZA, P. E. N. de; BASTOS, A. P. A.; DAMASCENO, E. A. M.; SOUZA, F. H. V.; AZEVEDO, R. B. de; BAÓ, S. N. Nanographene oxide-methylene blue as phototherapies platform for breast tumor ablation and metastasis prevention in a syngeneic orthotopic murine model. Journal of Nanobiotechnology, v. 16, n. 9, p. 1-17, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 53. | | FONSECA, F. M. da; HAACH, V.; BELLAVER, F. V.; BOMBASSARO, G.; GAVA, D.; SILVA, L. P. da; BARON, L. F.; SIMONELLY, M.; CARVALHO, W. A.; SCHAEFER, R.; BASTOS, A. P. A. Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine. Virology Journal, v. 20, 2023. Article number 187. Na publicação: Francisco Noé Fonseca; Ana Paula Bastos.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| 54. | | BARON, L. F.; FONSECA, F. M. da; MACIAG, S. S.; BELLAVER, F. A. V.; IBELLI, A. M. G.; MORES, M. A. Z.; ALMEIDA, G. F. de; GUTERRES, S. S.; BASTOS, A. P. A.; PAESE, K. Toltrazuril-loaded polymeric nanocapsules as a promising approach for the preventive control of coccidiosis in poultry. Pharmaceutics, v. 14, n. 392, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 55. | | IBELLI, A. M. G.; FERNANDES, L.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; OKINO, C. H.; PEIXOTO, J. de O.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Transcriptomic profiling shows the induction of humoral and cellular response-related genes in pigs following vaccination with an Influenza A nanovaccine. In: INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM, 13., 2023, Satellite Meeting. Programme & Abstracts... Kruger Park/South Africa: IVIS, 2023. p. 109.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 56. | | CARVALHO, W. A.; GASPAR, E. B.; PRUDENCIO, C. R.; SILVA, L. P. da; BONATTO, C.; BASTOS, A. P. A.; BRANDAO, H. de M.; DOMINGUES, R.; ORTS, D. J. B.; COSTA, H. H. M. da; GASPARI, E. de; FRANCO, A. L.; SILVA, A. S. Immunomodulatory nanosystems with active targeting to phagocytes promote the production of neutralizing antibodies against the SARCoV2 virus in cows' colostrum. In: CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 47., 2023, Ouro Preto. Program. São Paulo: Sociedade Brasileira de Imunologia, 2023. p. 278. Immuno 2023.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| 57. | | SOUZA, P. E. de A.; MOREIRA, L. dos S.; CARVALHO, C. V. de; HONÓRIO, N. T. de B. S.; BASTOS, A. P. A.; SILVA, L. P. da; PRUDÊNCIO, C. R.; DOMINGUES, R.; GASPAR, E. B.; FRANCO, A. L.; REIS, D. R. de L.; BRANDAO, H. de M.; DIAVÃO, J.; SILVA, A. S.; CAMPOS, M. M.; CARVALHO, W. A. Desenvolvimento de estratégias inovadoras de imunização para viabilizar o uso de vacas como biofábricas de anticorpos neutralizantes produzidos a partir do colostro para tratamento e prevenção de doenças pandêmicas. In: WORKSHOP DE INICIAÇÃO CIENTÍFICA DA EMBRAPA GADO DE LEITE, 28., 2023, Juiz de Fora. Anais... Juiz de Fora: Embrapa Gado de Leite, 2024. p. 31-35. (Embrapa Gado de Leite. Eventos Técnicos & Científicos, 1). Pibic/Fapemig.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| Registros recuperados : 57 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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Data corrente: |
24/08/2023 |
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Data da última atualização: |
04/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
FONSECA, F. M. da; HAACH, V.; BELLAVER, F. V.; BOMBASSARO, G.; GAVA, D.; SILVA, L. P. da; BARON, L. F.; SIMONELLY, M.; CARVALHO, W. A.; SCHAEFER, R.; BASTOS, A. P. A. |
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Afiliação: |
FRANCISCO NOE DA FONSECA, GEM; VANESSA HAACH, Universidade Federal do Rio Grande do Sul; FRANCIANA VOLPATO BELLAVER, Instituto Federal Catarinense; GABRIELLY BOMBASSARO, Instituto Federal Catarinense; DANIELLE GAVA, CNPSA; LUCIANO PAULINO DA SILVA, Cenargen; LANA FLAVIA BARON, Universidade Federal do Rio Grande do Sul; MAYARA SIMONELLY, Universidade de Brasília; WANESSA ARAUJO CARVALHO, CNPGL; REJANE SCHAEFER, CNPSA; ANA PAULA ALMEIDA BASTOS, CNPSA. |
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Título: |
Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Virology Journal, v. 20, 2023. Article number 187. |
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DOI: |
https://doi.org/10.1186/s12985-023-02158-0 |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Francisco Noé Fonseca; Ana Paula Bastos. |
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Conteúdo: |
Abstract
Background: Influenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health.
Vaccination of pigs is the most successful measure to mitigate the impact of the disease in the herds. Influenza-based
virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has
tolerability profile due to their purity and biocompatibility.
Methods: This study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and
neuraminidase proteins derived from the swine IAVs (swIAVs) H1N1, H1N2 and H3N2 subtypes, and to investigate
its effectiveness in mice as a potential vaccine for swine. Mice were immunized with two vaccine doses (1 and 15
days), intramuscularly and intranasally. At 21 days and eight months later after the second vaccine dose, mice were
euthanized. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with a
polyvalent influenza virosomal vaccine were investigated.
Results: Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion
and seroprotection (>4-fold rise in HI antibody titers, reaching a titer of ?1:40) were achieved in 80% of mice
(intramuscularly vaccinated group) at 21 days after booster immunization. Virus-neutralizing antibody titers against
IAV were detected at 8 months after vaccination, indicating long-lasting immunity. Overall, mice immunized with the
virosome displayed greater ability for B, effector-T and memory-T cells from the spleen to respond to H1N1, H1N2 and
H3N2 antigens.
Conclusions: All findings showed an efficient immune response against IAVs in mice vaccinated with a polyvalent
virosome-based influenza vaccine. MenosAbstract
Background: Influenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health.
Vaccination of pigs is the most successful measure to mitigate the impact of the disease in the herds. Influenza-based
virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has
tolerability profile due to their purity and biocompatibility.
Methods: This study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and
neuraminidase proteins derived from the swine IAVs (swIAVs) H1N1, H1N2 and H3N2 subtypes, and to investigate
its effectiveness in mice as a potential vaccine for swine. Mice were immunized with two vaccine doses (1 and 15
days), intramuscularly and intranasally. At 21 days and eight months later after the second vaccine dose, mice were
euthanized. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with a
polyvalent influenza virosomal vaccine were investigated.
Results: Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion
and seroprotection (>4-fold rise in HI antibody titers, reaching a titer of ?1:40) were achieved in 80% of mice
(intramuscularly vaccinated group) at 21 days after booster immunization. Virus-neutralizing antibody titers against
IAV were detected at 8 months after vaccination, indicating long-lasting immunity. Overall, mice immunized with the
virosome... Mostrar Tudo |
|
Palavras-Chave: |
Nanovaccine; Nanovacina; Nanovacinação; Seroprotection; Soro imunológico; Soro proteção; Soroproteção; Vaccine. |
|
Thesagro: |
Influenza Aviaria; Vacina; Vacinação; Vírus. |
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Thesaurus NAL: |
Influenza A virus; Vaccination. |
|
Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156329/1/Immunological-profile-of-mice-immunized-with-a-polyvalent-virosome.pdf
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|
Marc: |
LEADER 03009naa a2200433 a 4500
001 2156179
005 2023-09-04
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12985-023-02158-0$2DOI
100 1 $aFONSECA, F. M. da
245 $aImmunological profile of mice immunized with a polyvalent virosome-based influenza vaccine.$h[electronic resource]
260 $c2023
500 $aNa publicação: Francisco Noé Fonseca; Ana Paula Bastos.
520 $aAbstract Background: Influenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health. Vaccination of pigs is the most successful measure to mitigate the impact of the disease in the herds. Influenza-based virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has tolerability profile due to their purity and biocompatibility. Methods: This study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and neuraminidase proteins derived from the swine IAVs (swIAVs) H1N1, H1N2 and H3N2 subtypes, and to investigate its effectiveness in mice as a potential vaccine for swine. Mice were immunized with two vaccine doses (1 and 15 days), intramuscularly and intranasally. At 21 days and eight months later after the second vaccine dose, mice were euthanized. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with a polyvalent influenza virosomal vaccine were investigated. Results: Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion and seroprotection (>4-fold rise in HI antibody titers, reaching a titer of ?1:40) were achieved in 80% of mice (intramuscularly vaccinated group) at 21 days after booster immunization. Virus-neutralizing antibody titers against IAV were detected at 8 months after vaccination, indicating long-lasting immunity. Overall, mice immunized with the virosome displayed greater ability for B, effector-T and memory-T cells from the spleen to respond to H1N1, H1N2 and H3N2 antigens. Conclusions: All findings showed an efficient immune response against IAVs in mice vaccinated with a polyvalent virosome-based influenza vaccine.
650 $aInfluenza A virus
650 $aVaccination
650 $aInfluenza Aviaria
650 $aVacina
650 $aVacinação
650 $aVírus
653 $aNanovaccine
653 $aNanovacina
653 $aNanovacinação
653 $aSeroprotection
653 $aSoro imunológico
653 $aSoro proteção
653 $aSoroproteção
653 $aVaccine
700 1 $aHAACH, V.
700 1 $aBELLAVER, F. V.
700 1 $aBOMBASSARO, G.
700 1 $aGAVA, D.
700 1 $aSILVA, L. P. da
700 1 $aBARON, L. F.
700 1 $aSIMONELLY, M.
700 1 $aCARVALHO, W. A.
700 1 $aSCHAEFER, R.
700 1 $aBASTOS, A. P. A.
773 $tVirology Journal$gv. 20, 2023. Article number 187.
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Embrapa Suínos e Aves (CNPSA) |
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