Data/hora: 21/06/2024 18:25:11

Biblioteca(s): 	Embrapa Clima Temperado.	
Data corrente: 	17/12/2021	
Data da última atualização: 	17/12/2021	
Autoria: 	SILVA, D. T. da; SMANIOTTO, F. A.; COSTA, I. F.; BARANZELLI, J.; MULLER, A.; SOMACAL, S.; MONTEIRO, C. S.; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T.	
Afiliação: 	DARIANE TRIVISIOL DA SILVA; FRANCIELE ALINE SMANIOTTO; ISABELLA FERREIRA COSTA; JULIA BARANZELLI; ALINE MULLER; SABRINA SOMACAL; CAMILA SANT'ANNA MONTEIRO; MARCIA VIZZOTTO, CPACT; ELISEU RODRIGUES; MILENE TEIXEIRA BARCIA; TATIANA EMANUELLI.	
Título: 	Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	Food Chemistry, v. 364, 130370, Dec. 2021.	
DOI: 	doi.org/10.1016/j.foodchem.2021.130370	
Idioma: 	Inglês	
Conteúdo: 	This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins.	
Palavras-Chave: 	Composto.	
Thesagro: 	Extrato; Mirtilo.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/229347/1/Artigo-Natural-deep-eutectic-solvent.pdf	
Registro original: 	Embrapa Clima Temperado (CPACT)	
Exemplares: 	CPACT - (22139-1) - UPC - AP - DD -  -  -  - DIS