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10. | | SOARES, B. B.; BRUNES, L. C.; BALDI, F.; NARCISO, M. G.; CARMO, A. S. do; MAGNABOSCO, C. U. Associação genética entre escores visuais e características reprodutivas em bovinos Nelore. In: SEMINÁRIO JOVENS TALENTOS, 16., 2022, Santo Antônio de Goiás. Resumos... Brasília, DF: Embrapa; Santo Antônio de Goiás: Embrapa Arroz e Feijão, 2022. p. 74. Biblioteca(s): Embrapa Cerrados. |
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11. | | SOARES, B. B.; BRUNES, L. C.; BALDI, F.; NARCISO, M. G.; CARMO, A. S. do; MAGNABOSCO, C. U. Associação genética entre escores visuais e características reprodutivas em bovinos Nelore. In: SEMINÁRIO JOVENS TALENTOS, 16., 2022, Santo Antônio de Goiás. Resumos... Brasília, DF: Embrapa; Santo Antônio de Goiás: Embrapa Arroz e Feijão, 2022. p. 74. Biblioteca(s): Embrapa Arroz e Feijão. |
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12. | | CAMARGO, G. M. F. de; COSTA, R. B.; ALBUQUERQUE, L. G.; REGITANO, L. C. de A.; BALDI, F.; TONHATI, H. Association between JY-1 gene polymorphisms and reproductive traits in beef cattle. Gene, v. 533, n. 2, p. 477-480, jan. 2014. Biblioteca(s): Embrapa Pecuária Sudeste. |
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13. | | BUZANSKAS, M. E.; GROSSI, D. do A.; VENTURINI, G. C.; BALDI, F.; MUNARI, D. P.; ALENCAR, M. M. de. Estimativas de parâmetros genéticos para características reprodutivas e de crescimento em bovinos Canchim por método Bayesiano. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Anais...Maringa: SBZ:UEM, 2009. Biblioteca(s): Embrapa Pecuária Sudeste. |
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14. | | BRUNES, L. C.; BALDI, F.; COSTA, M. F. O. e; LOBO, R. B.; LOPES, F. B.; MAGNABOSCO, C. U. Genetic-quantitative analysis for reproductive traits in Nellor cattle selected for sexual precocity. Animal Production Science, v. 60, n. 7, p. 896-902, Mar. 2020. Biblioteca(s): Embrapa Arroz e Feijão; Embrapa Cerrados. |
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15. | | BRUNES, L. C.; BALDI, F.; NARCISO, M. G.; LOBO, R. B.; ESPIGOLAN, R.; COSTA, M. F. O.; MAGNABOSCO, C. U. Genomic prediction ability for feed efficiency traits using different models and pseudo-phenotypes under several validation strategies in Nelore cattle. Animal. The International Journal of Animal Biosciences, v. 15, 100085, 2021. Biblioteca(s): Embrapa Arroz e Feijão; Embrapa Cerrados. |
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17. | | PERIPOLLI, E.; MUNARI, D. P.; SILVA, M. V. G. B.; LIMA, A. L.; IRGANG, R.; BALDI, F. Runs of homozygosity: current knowledge and applications in livestock. Animal Genetics, v. 48, n. 3, p. 255-271, 2017. Publicado online em 1 dez. 2016. Biblioteca(s): Embrapa Gado de Leite. |
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18. | | CANESIN, R. C.; BERCHIELLI, T. T.; MESSANA, J. D.; BALDI, F.; PIRES, A. V.; FRIGHETTO, R. T. S.; FIORENTINI, G.; REIS, R. A. Effects of supplementation frequency on the ruminal fermentation and enteric methane production of beef cattle grazing in tropical pastures. Revista Brasileira de Zootecnia, Brasília, DF, v. 43, n. 11 , p. 590-600, 2014. Biblioteca(s): Embrapa Meio Ambiente. |
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19. | | PERIPOLLI, E.; STAFUZZA, N. B.; MACHADO, M. A.; PANETTO, J. C. do C.; EGITO, A. A. do; BALDI, F.; SILVA, M. V. G. B. Assessment of copy number variants in three Brazilian locally adapted cattle breeds using whole-genome re-sequencing data. Animal Genetics, v. 54, n. 3, p. 254-270, 2023. Biblioteca(s): Embrapa Gado de Leite. |
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20. | | BALDI, F.; FIGUEIREDO, L. G.; OLIVEIRA, H. N. de; MAGNABOSCO, C. de U.; BEZERRA, L. A. F.; FARIA, C. U.; LOBO, R. B. Bioeconomic selection index (EMGTe) for Nellore Brazil breeding program. In: International Conference on Quantitative Genetics, 5., 2016, Madison. Proceedings... Madison , 2016. (ICQG5) Biblioteca(s): Embrapa Cerrados. |
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Registro Completo
Biblioteca(s): |
Embrapa Cerrados. |
Data corrente: |
12/12/2018 |
Data da última atualização: |
12/12/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
STAFUZZA, N. B.; SILVA, R. M. de O.; PERIPOLLI, E.; BEZERRA, L. A. F.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; MUNARI, D. P.; LOURENCO, D. A. L.; BALDI, F. |
Afiliação: |
Nedenia Bonvino Stafuzza, UNESP; Rafael Medeiros de Oliveira Silva, University of Georgia; ELISA PERIPOLLI, UNESP; Luiz Antônio Framartino Bezerra, USP; Raysildo Barbosa Lôbo, Associaçao Nacional dos Criadores e Pesquisadores; CLAUDIO DE ULHOA MAGNABOSCO, CPAC; Fernando Di Croce, Zoetis; Jason Osterstock, Zoetis; Danísio Prado Munari, UNESP; Daniela A. Lino Lourenco, University of Georgia; Fernando Baldi, UNESP. |
Título: |
Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
PLoS ONE, v. 13, n. 8, e0202978, August 30, 2018. |
DOI: |
https://doi.org/10.1371/journal.pone.0202978 |
Idioma: |
Inglês |
Conteúdo: |
Abstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation. MenosAbstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Pollednes... Mostrar Tudo |
Thesagro: |
Bos Indicus; Gado Nelore; Mutação. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/188280/1/Genome-wide-association-study-provides-apagar.pdf
|
Marc: |
LEADER 02768naa a2200289 a 4500 001 2101347 005 2018-12-12 008 2018 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1371/journal.pone.0202978$2DOI 100 1 $aSTAFUZZA, N. B. 245 $aGenome-wide association study provides insights into genes related with horn development in Nelore beef cattle.$h[electronic resource] 260 $c2018 520 $aAbstract The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631?3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. Several genes are harbored in this region, and they may act together in the determination of the polled/horned phenotype. Fine mapping the locus responsible for polled trait in Nelore breed and the identification of the molecular mechanisms regulating the horn growth deserve further investigation. 650 $aBos Indicus 650 $aGado Nelore 650 $aMutação 700 1 $aSILVA, R. M. de O. 700 1 $aPERIPOLLI, E. 700 1 $aBEZERRA, L. A. F. 700 1 $aLOBO, R. B. 700 1 $aMAGNABOSCO, C. de U. 700 1 $aDI CROCE, F. 700 1 $aOSTERSTOCK, J. 700 1 $aMUNARI, D. P. 700 1 $aLOURENCO, D. A. L. 700 1 $aBALDI, F. 773 $tPLoS ONE$gv. 13, n. 8, e0202978, August 30, 2018.
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