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41. | | PERIPOLLI, E.; STAFUZZA, N. B.; MUNARI, D. P.; LIMA, A. L. F.; IRGANG, R.; MACHADO, M. A.; PANETTO, J. C. do C.; VENTURA, R. V.; BALDI, F.; SILVA, M. V. G. B. Assessment of runs of homozygosity islands and estimates of genomic inbreeding in Gyr (Bos indicus) dairy cattle. BMC Genomics, v. 19, n. 34, 2018. 13 p. Biblioteca(s): Embrapa Gado de Leite. |
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42. | | LOPES, F. B.; MAGNABOSCO, C. de U.; PASSAFARO, T. L.; BRUNES, L. C.; COSTA, M. F. O. e; EIFERT, E. da C.; NARCISO, M. G.; ROSA, G. J. M.; LOBO, R. B.; BALDI, F. Improving genomic prediction accuracy for meat tenderness in Nellore cattle using artificial neural networks. Journal of Animal Breeding and Genetics, v. 137, n. 5, 2020. p. 438-448 Biblioteca(s): Embrapa Arroz e Feijão; Embrapa Cerrados. |
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43. | | BRUNES, L. C.; MAGNABOSCO, C. de U.; BALDI, F. S.; COSTA, M. F. O. e; QUEIROZ, L. C. R. de; LOBO, R. B.; GUIMARAES, N. C.; LOPES, F. B. Estimates of genetic parameters for carcass and reproductive traits in Nelore cattle. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 55.; CONGRESSO BRASILEIRO DE ZOOTECNIA, 28., 2018, Goiânia. Construindo saberes, formando pessoas e transformando a produção animal: anais eletrônicos. Goiânia: Sociedade Brasileira de Zootecnia, 2018. Biblioteca(s): Embrapa Arroz e Feijão. |
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44. | | BRUNES, L. C.; MAGNABOSCO, C. de U.; BALDI, F. S.; COSTA, M. F. O. e; QUEIROZ, L. C. R. de; LOBO, R. B.; GUIMARAES, N. C.; LOPES, F. B. Estimates of genetic parameters for carcass and reproductive traits in Nelore cattle. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 55.; CONGRESSO BRASILEIRO DE ZOOTECNIA, 28., 2018, Goiânia. Construindo saberes, formando pessoas e transformando a produção animal: anais eletrônicos. Goiânia: Sociedade Brasileira de Zootecnia, 2018. Biblioteca(s): Embrapa Cerrados. |
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45. | | CAMARGO, G. M. F. de; GIL. F. M. M.; CARDOSO, D. F.; FONSECA, P. D. da S.; ZETOUNI, L.; BRAZ. C. U.; SOUZA, F. R. P. de; BALDI, F.; ALBUQUERQUE, L. G. de; REGITANO, L. C. de A.; TONHATI, H. Monomorphism for partial region of exon 3 of jy-1 gene in nellore heifers. Archivos Latinoamericano de Producion Animal, v. 19, (supl. 1), p. 192, 2011 Biblioteca(s): Embrapa Pecuária Sudeste. |
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46. | | TONHATI, H.; CAMARGO, G. M. F. de; GIL, F. M. M.; CARDOSO, D. F.; FONSECA, P. D. da S.; ZETOUNI, L.; BRAZ, C. U.; SOUZA, F. R. P. DE; BALDI, F.; ALBUQUERQUE, L. G. de; REGITANO, L. C. de A. Partial characterization of exon 3 of jy-1 gene in Bos taurus indicus. Archivos Latinoamericano de Producion Animal, v. 19, (supl. 1), p. 200, 2011. Biblioteca(s): Embrapa Pecuária Sudeste. |
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47. | | BORGES, B. O.; CURI, R. A.; BALDI, F.; FEITOSA, F. L. B.; ANDRADE, W. B. F. de; ALBUQUERQUE, L. G. de; OLIVEIRA, H. N. de; CHARDULO, L. A. L. Polymorphisms in candidate genes and their association with carcass traits and meat quality in Nellore cattle. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 49, n. 5, p. 364-371, maio. 2014. Título em português: Polimorfismos em genes-candidatos e suas associações com características de carcaça e qualidade da carne em bovinos Nelore. Biblioteca(s): Embrapa Unidades Centrais. |
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48. | | PERIPOLLI, E.; METZGER, J.; LEMOS, M. V. A. de; STAFUZZA, N. B.; KLUSKA, S.; OLIVIERI, B. F.; FEITOSA, F. L. B.; BERTON, M. P.; LOPES, F. B.; MUNARI, D. P.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; DENISE, S.; PEREIRA, A. S. C.; BALDI, F. Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits. BMC Genomics, v. 19, 680, 2018. Biblioteca(s): Embrapa Cerrados. |
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49. | | KLUSKA, S.; OLIVIERI, B. F.; BONAMY, M.; CHIAIA, H. L. J.; FEITOSA, F. L. B.; BERTON, M. P.; PERIPOLLI, E.; LEMOS, M. V. A.; TONUSSI, R. L.; LOBO, R. B.; MAGNABOSCO, C. de U.; CI CROCE, F.; OSTERSTOCK, J.; PEREIRA, A. S. C.; MUNARI, D. P.; BEZERRA, L. A.; LOPES, F. B.; BALDI, F. Estimates of genetic parameters for growth, reproductive, and carcass traits in Nelore cattle using the single step genomic BLUP procedure. Livestock Science, v. 216, p. 203-209, October 2018. Biblioteca(s): Embrapa Cerrados. |
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50. | | CAMARGO, G. M. F. de; CARDOSO, D. F.; GIL, F. M. M.; FONSECA, P. D. da S.; ZETOUNI, L.; BRAZ, C. U.; FREITAS, A. C.; SOUZA, F. R. P. de; ASPILCUETA-BORQUIS, R. R.; BALDI, F.; ALBUQUERQUE, L. G. de; REGITANO, L. C. de A.; TONHATI, H. First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits. Molecular Biology Reporter, v. 39, p. 10105-10109, 2012. Biblioteca(s): Embrapa Pecuária Sudeste. |
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51. | | FERRINHO, A. M.; NASSU, R. T.; ALDAI, N.; LAMAS, L. B.; FURLAN, M. de L. do N.; TODA, B. M.; UTEMBERGUE, B. L.; REZENDE, R. G. de; MUELLER, L. F.; FURLAN, J. de J. M.; ZANATA, M.; BALDI, F.; PEREIRA, A. S. C. Whole cottonseed, vitamin E and finishing period affect the fatty acid profile and sensory traits of meat products from Nellore cattle. Meat Science, v. 138, p. 15-22, apr. 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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Registros recuperados : 51 | |
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Registro Completo
Biblioteca(s): |
Embrapa Cerrados. |
Data corrente: |
12/12/2018 |
Data da última atualização: |
12/12/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
PERIPOLLI, E.; METZGER, J.; LEMOS, M. V. A. de; STAFUZZA, N. B.; KLUSKA, S.; OLIVIERI, B. F.; FEITOSA, F. L. B.; BERTON, M. P.; LOPES, F. B.; MUNARI, D. P.; LOBO, R. B.; MAGNABOSCO, C. de U.; DI CROCE, F.; OSTERSTOCK, J.; DENISE, S.; PEREIRA, A. S. C.; BALDI, F. |
Afiliação: |
ELISA PERIPOLLI, UNESP; JULIA METZGER, University of Veterinary Medicine Hannover; MARCOS VINICIUS ANTUNES DE LEMOS, UNESP; NEDENIA BONVINOSTAFUZZA, UNESP; SABRINA KLUSKA, UNESP; BIANCA FERREIRA OLIVIERI, UNESP; FABIELI LOUISE BRAGA FEITOSA, UNESP; MARIANA PIATTO BERTON, UNESP; FERNANDO BRITO LOPES, UNESP; DANISIO PRADO MUNARI, UNESP; RAYSILDO BARBOSA LOBO, Associação Nacional de Criadores e Pesquisadores; CLAUDIO DE ULHOA MAGNABOSCO, CPAC; FERNANDO DI CROCE, Zoetis; JASON OSTERSTOCK, Zoetis; SUE DENISE, Zoetis; ANGELICA SIMONE CRAVO PEREIRA, USP; FERNANDO BALDI, UNESP. |
Título: |
Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
BMC Genomics, v. 19, 680, 2018. |
DOI: |
https://dx.doi.org/10.1186%2Fs12864-018-5060-8 |
Idioma: |
Inglês |
Conteúdo: |
Abstract Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages. It attempts also to compare estimates of inbreeding calculated from ROH (FROH), genomic relationship matrix (FGRM), and pedigree-based coefficient (FPED). Results The average number of ROH per animal was 55.15 ± 13.01 with an average size of 3.24 Mb. The Nellore genome is composed mostly by a high number of shorter segments accounting for 78% of all ROH, although the proportion of the genome covered by them was relatively small. The genome autozygosity proportion indicates moderate to high inbreeding levels for classical standards, with an average value of 7.15% (178.70 Mb). The average of FPED and FROH, and their correlations (− 0.05 to 0.26) were low. Estimates of correlation between FGRM-FPED was zero, while the correlation (− 0.01 to − 0.07) between FGRM-FROH decreased as a function of ROH length, except for FROH > 8Mb (− 0.03). Overall, inbreeding coefficients were not high for the genotyped animals. Autozygosity islands were evident across the genome (n = 62) and their genomic location did not largely differ within lineages. Enriched terms (p < 0.01) associated with defense response to bacteria (GO:0042742), immune complex reaction (GO:0045647), pregnancy-associated glycoproteins genes (GO:0030163), and organism growth (GO:0040014) were described within the autozygotic islands. Conclusions Low FPED-FROH correlation estimates indicate that FPED is not the most suitable method for capturing ancient inbreeding when the pedigree does not extend back many generations and FROH should be used instead. Enriched terms (p < 0.01) suggest a strong selection for immune response. Non-overlapping islands within the lineages greatly explain the mechanism underlying selection for functionally important traits in Nellore cattle. MenosAbstract Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages. It attempts also to compare estimates of inbreeding calculated from ROH (FROH), genomic relationship matrix (FGRM), and pedigree-based coefficient (FPED). Results The average number of ROH per animal was 55.15 ± 13.01 with an average size of 3.24 Mb. The Nellore genome is composed mostly by a high number of shorter segments accounting for 78% of all ROH, although the proportion of the genome covered by them was relatively small. The genome autozygosity proportion indicates moderate to high inbreeding levels for classical standards, with an average value of 7.15% (178.70 Mb). The average of FPED and FROH, and their correlations (− 0.05 to 0.26) were low. Estimates of correlation between FGRM-FPED was zero, while the correlation (− 0.01 to − 0.07) between FGRM-FROH decreased as a function of ROH length, except for FROH > 8Mb (− 0.03). Overall, inbreeding coefficients were not high for the genotyped animals. Autozygosity islands were evident across the genome (n = 62) and their genomic location did not largely differ within lineages. Enriched terms (p < 0.01) associated with defense response to bacteria (GO:0042742), immune complex reaction (GO:0045647), pr... Mostrar Tudo |
Palavras-Chave: |
Padroes ROH. |
Thesagro: |
Endogamia; Gado Nelore; Genética Animal; Genoma. |
Thesaurus NAL: |
Homozygosity. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/188276/1/12864-2018-Article-5060-APAGAR.pdf
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Marc: |
LEADER 03204naa a2200397 a 4500 001 2101339 005 2018-12-12 008 2018 bl uuuu u00u1 u #d 024 7 $ahttps://dx.doi.org/10.1186%2Fs12864-018-5060-8$2DOI 100 1 $aPERIPOLLI, E. 245 $aAutozygosity islands and ROH patterns in Nellore lineages$bevidence of selection for functionally important traits.$h[electronic resource] 260 $c2018 520 $aAbstract Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages. It attempts also to compare estimates of inbreeding calculated from ROH (FROH), genomic relationship matrix (FGRM), and pedigree-based coefficient (FPED). Results The average number of ROH per animal was 55.15 ± 13.01 with an average size of 3.24 Mb. The Nellore genome is composed mostly by a high number of shorter segments accounting for 78% of all ROH, although the proportion of the genome covered by them was relatively small. The genome autozygosity proportion indicates moderate to high inbreeding levels for classical standards, with an average value of 7.15% (178.70 Mb). The average of FPED and FROH, and their correlations (− 0.05 to 0.26) were low. Estimates of correlation between FGRM-FPED was zero, while the correlation (− 0.01 to − 0.07) between FGRM-FROH decreased as a function of ROH length, except for FROH > 8Mb (− 0.03). Overall, inbreeding coefficients were not high for the genotyped animals. Autozygosity islands were evident across the genome (n = 62) and their genomic location did not largely differ within lineages. Enriched terms (p < 0.01) associated with defense response to bacteria (GO:0042742), immune complex reaction (GO:0045647), pregnancy-associated glycoproteins genes (GO:0030163), and organism growth (GO:0040014) were described within the autozygotic islands. Conclusions Low FPED-FROH correlation estimates indicate that FPED is not the most suitable method for capturing ancient inbreeding when the pedigree does not extend back many generations and FROH should be used instead. Enriched terms (p < 0.01) suggest a strong selection for immune response. Non-overlapping islands within the lineages greatly explain the mechanism underlying selection for functionally important traits in Nellore cattle. 650 $aHomozygosity 650 $aEndogamia 650 $aGado Nelore 650 $aGenética Animal 650 $aGenoma 653 $aPadroes ROH 700 1 $aMETZGER, J. 700 1 $aLEMOS, M. V. A. de 700 1 $aSTAFUZZA, N. B. 700 1 $aKLUSKA, S. 700 1 $aOLIVIERI, B. F. 700 1 $aFEITOSA, F. L. B. 700 1 $aBERTON, M. P. 700 1 $aLOPES, F. B. 700 1 $aMUNARI, D. P. 700 1 $aLOBO, R. B. 700 1 $aMAGNABOSCO, C. de U. 700 1 $aDI CROCE, F. 700 1 $aOSTERSTOCK, J. 700 1 $aDENISE, S. 700 1 $aPEREIRA, A. S. C. 700 1 $aBALDI, F. 773 $tBMC Genomics$gv. 19, 680, 2018.
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