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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
15/02/2017 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LÔBO, R. B.; NKRUMAH, D.; GROSSI, D. do A.; BARROS, P. S. de; PAIVA, P.; BEZERRA, L. A. F.; OLIVEIRA, H. N. de; SILVA, M. V. G. B. |
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Afiliação: |
Raysildo Barbosa Lôbo, USP; Donald Nkrumah, Pfizer Animal Genetics - Kalamazoo, MI, USA; Daniela do Amaral Grossi, ANCP; Priscila Sales de Barros, Pfizer Animal Genetics - SP; Pablo Paiva, Pfizer Saúde Animal - SP; Luiz Antônio Framatino Bezerra, USP; Henrique Nunes de Oliveira, UNESP; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL. |
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Título: |
Implementation of DNA markers to produce genomically - enhanced EPDs in Nellore cattle. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Acta Scientiae Veterinariae, v. 39, suppl. 1, p. s23-s27, 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Background: The sequencing and publication of the cattle genome and the identification of single nucleotide polymorphism (SNP) molecular markers have provided new tools for animal genetic evaluation and genomic-enhanced selection. These new tools aim to increase the accuracy and scope of selection while decreasing generation interval. The objective of this study was to evaluate the enhancement of accuracy caused by the use of genomic information (Clarifide® - Pfizer) on genetic evaluation of Brazilian Nellore cattle. Review: The application of genome-wide association studies (GWAS) is recognized as one of the most practical approaches to modern genetic improvement. Genomic selection is perhaps most suited to the improvement of traits with low heritability in zebu cattle. The primary interest in livestock genomics has been to estimate the effects of all the markers on the chip, conduct cross-validation to determine accuracy, and apply the resulting information in GWAS either alone [9] or in combination with bull test and pedigree-based genetic evaluation data. The cost of SNP50K genotyping however limits the commercial application of GWAS based on all the SNPs on the chip. However, reasonable predictability and accuracy can be achieved in GWAS by using an assay that contains an optimally selected predictive subset of markers, as opposed to all the SNPs on the chip. The best way to integrate genomic information into genetic improvement programs is to have it included in traditional genetic evaluations. This approach combines traditional expected progeny differences based on phenotype and pedigree with the genomic breeding values based on the markers. Including the different sources of information into a multiple trait genetic evaluation model, for within breed dairy cattle selection, is working with excellent results. However, given the wide genetic diversity of zebu breeds, the high-density panel used for genomic selection in dairy cattle (Ilumina Bovine SNP50 array) appears insufficient for across-breed genomic predictions and selection in beef cattle. Today there is only one breed-specific targeted SNP panel and genomic predictions developed using animals across the entire population of the Nellore breed (www.pfizersaudeanimal.com), which enables genomically - enhanced selection. Genomic profiles are a way to enhance our current selection tools to achieve more accurate predictions for younger animals. Material and Methods: We analyzed the age at first calving (AFC), accumulated productivity (ACP), stayability (STAY) and heifer pregnancy at 30 months (HP30) in Nellore cattle fitting two different animal models; 1) a traditional single trait model, and 2) a two-trait model where the genomic breeding value or molecular value prediction (MVP) was included as a correlated trait. All mixed model analyses were performed using the statistical software ASREML 3.0. Results: Genetic correlation estimates between AFC, ACP, STAY, HP30 and respective MVPs ranged from 0.29 to 0.46. Results also showed an increase of 56%, 36%, 62% and 19% in estimated accuracy of AFC, ACP, STAY and HP30 when MVP information was included in the animal model. Conclusion: Depending upon the trait, integration of MVP information into genetic evaluation resulted in increased accuracy of 19% to 62% as compared to accuracy from traditional genetic evaluation. GE-EPD will be an effective tool to enable faster genetic improvement through more dependable selection of young animals. MenosBackground: The sequencing and publication of the cattle genome and the identification of single nucleotide polymorphism (SNP) molecular markers have provided new tools for animal genetic evaluation and genomic-enhanced selection. These new tools aim to increase the accuracy and scope of selection while decreasing generation interval. The objective of this study was to evaluate the enhancement of accuracy caused by the use of genomic information (Clarifide® - Pfizer) on genetic evaluation of Brazilian Nellore cattle. Review: The application of genome-wide association studies (GWAS) is recognized as one of the most practical approaches to modern genetic improvement. Genomic selection is perhaps most suited to the improvement of traits with low heritability in zebu cattle. The primary interest in livestock genomics has been to estimate the effects of all the markers on the chip, conduct cross-validation to determine accuracy, and apply the resulting information in GWAS either alone [9] or in combination with bull test and pedigree-based genetic evaluation data. The cost of SNP50K genotyping however limits the commercial application of GWAS based on all the SNPs on the chip. However, reasonable predictability and accuracy can be achieved in GWAS by using an assay that contains an optimally selected predictive subset of markers, as opposed to all the SNPs on the chip. The best way to integrate genomic information into genetic improvement programs is to have it included in tradit... Mostrar Tudo |
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Palavras-Chave: |
DNA Markers; Genetic Evaluation; Genomic Enhanced EPDs; Genomic Selection; Nellore Cattle; SNP. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/155805/1/Cnpgl-2016-ActaSciVet-Implementation.pdf
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Marc: |
LEADER 04311naa a2200277 a 4500
001 2064370
005 2023-01-30
008 2011 bl uuuu u00u1 u #d
100 1 $aLÔBO, R. B.
245 $aImplementation of DNA markers to produce genomically - enhanced EPDs in Nellore cattle.$h[electronic resource]
260 $c2011
520 $aBackground: The sequencing and publication of the cattle genome and the identification of single nucleotide polymorphism (SNP) molecular markers have provided new tools for animal genetic evaluation and genomic-enhanced selection. These new tools aim to increase the accuracy and scope of selection while decreasing generation interval. The objective of this study was to evaluate the enhancement of accuracy caused by the use of genomic information (Clarifide® - Pfizer) on genetic evaluation of Brazilian Nellore cattle. Review: The application of genome-wide association studies (GWAS) is recognized as one of the most practical approaches to modern genetic improvement. Genomic selection is perhaps most suited to the improvement of traits with low heritability in zebu cattle. The primary interest in livestock genomics has been to estimate the effects of all the markers on the chip, conduct cross-validation to determine accuracy, and apply the resulting information in GWAS either alone [9] or in combination with bull test and pedigree-based genetic evaluation data. The cost of SNP50K genotyping however limits the commercial application of GWAS based on all the SNPs on the chip. However, reasonable predictability and accuracy can be achieved in GWAS by using an assay that contains an optimally selected predictive subset of markers, as opposed to all the SNPs on the chip. The best way to integrate genomic information into genetic improvement programs is to have it included in traditional genetic evaluations. This approach combines traditional expected progeny differences based on phenotype and pedigree with the genomic breeding values based on the markers. Including the different sources of information into a multiple trait genetic evaluation model, for within breed dairy cattle selection, is working with excellent results. However, given the wide genetic diversity of zebu breeds, the high-density panel used for genomic selection in dairy cattle (Ilumina Bovine SNP50 array) appears insufficient for across-breed genomic predictions and selection in beef cattle. Today there is only one breed-specific targeted SNP panel and genomic predictions developed using animals across the entire population of the Nellore breed (www.pfizersaudeanimal.com), which enables genomically - enhanced selection. Genomic profiles are a way to enhance our current selection tools to achieve more accurate predictions for younger animals. Material and Methods: We analyzed the age at first calving (AFC), accumulated productivity (ACP), stayability (STAY) and heifer pregnancy at 30 months (HP30) in Nellore cattle fitting two different animal models; 1) a traditional single trait model, and 2) a two-trait model where the genomic breeding value or molecular value prediction (MVP) was included as a correlated trait. All mixed model analyses were performed using the statistical software ASREML 3.0. Results: Genetic correlation estimates between AFC, ACP, STAY, HP30 and respective MVPs ranged from 0.29 to 0.46. Results also showed an increase of 56%, 36%, 62% and 19% in estimated accuracy of AFC, ACP, STAY and HP30 when MVP information was included in the animal model. Conclusion: Depending upon the trait, integration of MVP information into genetic evaluation resulted in increased accuracy of 19% to 62% as compared to accuracy from traditional genetic evaluation. GE-EPD will be an effective tool to enable faster genetic improvement through more dependable selection of young animals.
653 $aDNA Markers
653 $aGenetic Evaluation
653 $aGenomic Enhanced EPDs
653 $aGenomic Selection
653 $aNellore Cattle
653 $aSNP
700 1 $aNKRUMAH, D.
700 1 $aGROSSI, D. do A.
700 1 $aBARROS, P. S. de
700 1 $aPAIVA, P.
700 1 $aBEZERRA, L. A. F.
700 1 $aOLIVEIRA, H. N. de
700 1 $aSILVA, M. V. G. B.
773 $tActa Scientiae Veterinariae$gv. 39, suppl. 1, p. s23-s27, 2011.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 253 | |
| 241. |  | SANTOS, R. C. dos; ARRIEL, N. H. C.; FREIRE, R. M. M.; GONDIM, T. M. de S.; FÁVERO, A. P.; NOGUEIRA, R. J. M. C.; MELO FILHO, P. de A. Produção de sementes e bromatologia de linhagem avançada oriunda de cruzamentos interespecíficos de Arachis, com potencial para fins forrageiros. In: CONGRESSO BRASILEIRO DE MELHORAMENTO DE PLANTAS, 4., 2007, São Lourenço. 4 p.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Algodão. |
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| 242. | | ARRIEL, N. H. C.; ANTONIASSI, R.; FREITAS, S. C. de; BIZZO, H. R.; CAVALCANTI, N. T. F.; FARIAS, A. L. de; SOUSA, F. F. de; ROCHA, G. M. G. da. Rendimento e qualidade de óleo de genótipos de gergelim da Embrapa Algodão. CONGRESSO BRASILEIRO DE MAMONA, 5.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 2.; FÓRUM CAPIXABA DE PINHÃO-MANSO, 1., 2012, Guarapari. Desafios e Oportunidades: anais. Campina Grande: Embrapa Algodão, 2012. p. 387| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Algodão. |
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| 243. | | ARRIEL, N. H. C.; ANTONIASSI, R.; FREITAS, S. C. de; BIZZO, H. R.; CAVALCANTI, N. T. F.; FARIAS, A. L. de; SOUSA, F. F. de; ROCHA, G. M. G. da. Rendimento e qualidade de óleo de progênies de gergelim da Embrapa Algodão. CONGRESSO BRASILEIRO DE MAMONA, 5.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 2.; FÓRUM CAPIXABA DE PINHÃO-MANSO, 1., 2012, Guarapari. Desafios e Oportunidades: anais. Campina Grande: Embrapa Algodão, 2012. p. 388| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Algodão. |
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| 244. | | SEVERINO, L. S.; LIMA, R. L. S.; LUCENA, A. M. A.; FREIRE, M. A. O.; SAMPAIO, L. R.; VERAS, R. P.; MEDEIROS, K. A. A. L.; SOFIATTI, V.; ARRIEL, N. H. C. Propagation by stem cuttings and root system structure of Jatropha curcas. Biomass & Bioenergy, n. 35, p. 3160-3166, 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Algodão. |
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| 245. | | LIMA, G. B. P. de; GOMES, E. F.; ROCHA, G. M. G. da; SILVA, F. de A.; FERNANDES, P. D.; MACHADO, A. P.; FERNANDES JUNIOR, P. I.; MELO, A. S. de; ARRIEL, N. H. C.; GONDIM, T. M. de S.; LIMA, L. M. de. Bacilli rhizobacteria as biostimulants of growth and production of sesame cultivars under water deficit. Plants, v. 12, 6, 1337, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Algodão; Embrapa Semiárido. |
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| 246. | | ALBUQUERQUE, F. A. de; ARRIEL, N. H. C.; BLACKBURN, R. M.; SANTIAGO, F. dos S.; ALVES, I.; VALE, D. G.; GUIMARAES, F. M.; CARDOSO, G. D.; ALCANTARA, P. C. L. de; FEITOSA, F. F.; CAVACANTI, A.; MEIRELES, A. B. de; SILVA, V. A. da. Algodão em consorcios agroecológicos: experiência de reintrodução do algodão na agricultura familiar nordestina. In: CONGRESSO BRASILEIRO DO ALGODÃO, 8.; COTTON EXPO, 1., 2011, São Paulo. Evolução da cadeia para construção de um setor forte: Anais. Campina Grande, PB: Embrapa Algodão, 2011. p.1735-1739| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Algodão. |
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| 247. | | BUSTAMANTE, P. G.; GOEDERT, C. O.; VIEIRA, R. F.; CARGNIN, A.; CASTRO, A. C. R. de; WALTER, B. M. T.; MACHADO, C. de F.; FREITAS, F. O.; LOPES, J. F.; PADUA, J. G.; JANK, L.; GIMENES, M. A.; OLIVEIRA, M. do S. P. de; LAMEIRA, O. A.; ARRIEL, N. H. C.; SANTOS, V. da S. Rede brasileira de recrusos genéticos vegetais. In: SIMPOSIO INTERNACIONAL DE RECURSOS GENÉTICOS PARA AMÉRICA LATINA Y EL CARIBE, 8., 2011, Quito. [Proceedings...] Quito: INIAP, 2011. SIRGEALC.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 248. | | BUSTAMANTE, P. G.; GOEDERT, C. O.; VIEIRA, R. F.; CARGNIN, A.; CASTRO, A. C. R. de; WALTER, B. M. T.; MACHADO, C. de F.; FREITAS, F. O.; LOPES, J. F.; PADUA, J. G.; JANK, L.; GIMENES, M. A.; OLIVEIRA, M. do S. P. de; LAMEIRA, O. A.; ARRIEL, N. H. C.; SANTOS, V. da S. Rede brasileira de recrusos genéticos vegetais. In: SIMPOSIO INTERNACIONAL DE RECURSOS GENÉTICOS PARA AMÉRICA LATINA Y EL CARIBE, 8., 2011, Quito. [Proceedings...] Quito: INIAP, 2011. 3 p. SIRGEALC. Exposición de Trabajos - Posters - Rede Brasileira de Recursos Genéticos Vegetais.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental; Embrapa Gado de Corte. |
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| 249. | | ROCHA, M. do S.; LUCENA, A. M. A. de; OLIVEIRA, M. I. P. de; BELTRÃO, N. E. de M.; ARRIEL, N. H. C.; CARVALHO, J. M. F. C.; ALMEIDA, F. de A. C.; BRUNO, R. de L. A.; GONÇALVES, E. P. Germinação de sementes pinhão manso em diferentes substratos e temperatura. In: CONGRESSO BRASILEIRO DE PLANTAS OLEAGINOSAS, ÓLEOS, GORDURAS E BIODIESEL, 5.; CLÍNICA TECNOLÓGICA EM BIODIESEL, 2., 2008, Lavras. Biodiesel: tecnologia limpa. Anais... Lavras: UFLA, 2008. 9 p. Seção Trabalhos. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Algodão. |
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| 250. | | ARRIEL, N. H. C.; GONDIM, T. M. de S.; FIRMINO, P. de T.; BELTRAO, N. E. de M.; VASCONCELOS, R. A. de; COSTA, I. L. da; SILVEIRA, N. A. da; SOUSA, S. L. de; DANTAS, E. S. B.; PEREIRA, J. R. Gergelim BRS Seda. 3 ed. Campina Grande: Empresa Brasileira de Pesquisa Agropecuária, 2009. 1 folder| Biblioteca(s): Embrapa Algodão. |
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| 251. | | SANTOS, R. C. dos; MELO FILHO, P. de A.; SILVA, A. F.; GONDIM, T. M. de S.; OLIVEIRA JÚNIOR, J. O. L. de; ARAÚJO NETO, R. B. de; SAGRILO, E.; ARRIEL, N. H. C.; VASCONCELOS, R. A. de; OLIVEIRA, A. P. D. de; FREIRE, R. M. M. Produtividade de amendoim rasteiro em cinco estados do Nordeste. In: CONGRESSO BRASILEIRO DE MAMONA, 4.; SIMPÓSIO INTERNACIONAL DE OLEAGINOSAS ENERGÉTICAS, 1., 2010, João Pessoa. Inclusão social e energia: anais. Campina Grande: Embrapa Algodão, 2010.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Algodão. |
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| 252. | | QUEIROGA, V. de P.; CHAVEZ LEÓN, J. V.; PEREZ VALENZUELA, F. J.; BUSO, J. A.; ORELLANA, C. E. I.; FLORES, J. O. C.; ARRIEL, N. H. C.; FIRMINO, P. de T.; SILVA, A. C.; RAMÍREZ, J. R.; LAINEZ NAVARRET, R. M. Sistema de cultivo do gergelim orgânico para agricultura familiar. In: QUEIROGA, V. de P.; CHAVEZ LEÓN, J. V.; PEREZ VALENZUELA, F. J.; BUSO, J. A. (Ed.). Cultivo de ajonjolí para los campesinos en los departamentos de choluteca y valle. Campina Grande: AREPB, 2018. 169 p. il.; color. 12-139 Capítulo I.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Algodão. |
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| 253. | | FIRMINO, P. de T.; SILVA, A. C.; QUEIROGA, V. de P.; CARDONA, T.; SICOLI, A. H.; CHAVEZ LEÓN, J. V.; PEREZ VALENZUELA, F. J.; BUSO, J. A.; ARRIEL, N. H. C.; ORELLANA, C. E. I.; FLORES, J. O. C.; RAMÍEREZ, J. R.; LAINEZ NAVARRETE, R. M. Uso alimentario y nutricional del ajonjolí. In: QUEIROGA, V. de P.; CHAVEZ LEÓN, J. V.; PEREZ VALENZUELA, F. J.; BUSO, J. A. (Ed.). Cultivo de ajonjolí para los campesinos en los departamentos de choluteca y valle. Campina Grande: AREPB, 2018. 169 p. il.; color. 140-160 Capítulo II.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Algodão; Embrapa Unidades Centrais. |
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| Registros recuperados : 253 | |
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