Data/hora: 12/06/2024 12:24:10

Biblioteca(s): | Embrapa Agroindústria de Alimentos.
Tipo da produção científica: | Artigo em Periódico Indexado
Circulação/Nível: | A - 1
Data corrente: | 09/10/2018
Data da última atualização: | 13/12/2018
Autoria: | RODRIGUES, R.; GUERRA, G.; SOARES, J.; SANTOS, K. M. O. dos; ROLIM F.; ASSIS, P.; ARAUJO, D.; ARAÚJO JÚNIOR, R. F. de; GARCIA, V. B.; ARAÚJO, A. A. de; QUEIROGA, R.
Afiliação: | Raphaela Rodrigues, UFP; Gerlane Guerra, UFRJ; Juliana Soares, UFCG; KARINA MARIA OLBRICH DOS SANTOS, CTAA; Fernanda Rolim, UFP; Paloma Assis, UFP; Daline Araújo, UFRN; Raimundo F. de Araújo Júnior, UFRJ; Vinícius B. Garcia, UFRN; Aurigena A. de Araújo, UFRN; Rita Queirogaa, UFP.
Título: | Lactobacillus rhamnosus EM1107 in goat milk matrix modulates intestinal inflammation involving NF-kB p65 and SOCs-1 in an acid-induced colitis model.
Ano de publicação: | 2018
Fonte/Imprenta: | Journal of Functional Foods, v. 50, p. 78-92, 2018.
Idioma: | Português
Conteúdo: | Inflammatory Bowel Diseases (IBD) is characterized by a deregulated immune response. Probiotics are able to modulate the intestinal microbiota and regulating inflammatory responses. This study evaluated the effect of pretreatment of Lactobacillus rhamnosus EM1107, isolated (EM1107) or added to goat cheese (LRC), on acetic acid-induced colitis in rats. EM1107 or LRC had a protective effect on intestinal inflammation, with the improvement of disease activity index and macroscopic damage caused by inflammation. It also reduced myeloperoxidase, TNF-?, IL-1? colonic levels and improved oxidative stress. The histological evaluation confirmed the beneficial effect in colonic tissue preservation. Intestinal immunohistochemical analysis revealed down-regulation of IL-17, NF-?B p65, MMP-2, MMP-9, and iNOS expression, up-regulation of SOCs-1, ZO-1 and MUC-2, which are important intestinal mucosal barrier proteins. These results suggest that Lactobacillus rhamnosus EM1107 alone or added to goat cheese exerts a preventive effect against acetic acid-induced damage and may be an alternative to human IBD.
Thesaurus Nal: | Probiotics.
Categoria do assunto: | --
Registro original: | Embrapa Agroindústria de Alimentos (CTAA)
Exemplares: | CTAA - (14237-1) - UPC - AP - DD -  -  -  - DIS